The antimigraine drug ergotamine is endowed with antihyperalgesic activity

Phytotherapy Research

Volumn 12, Issue SUPPL. 1, 1998, Pages

  Ghelardini, C ^a   Galeotti, N ^a   Donaldson, S ^b   Bartolini, A ^a  

^a Dept Preclin and Clin Pharmacol ^*  (Italy)

^b Interuniv Ctr Neurochem Clin P   (Italy)

Author keywords

Analgesia; Ergotamine; Hyperalgesia; Migraine; Morphine withdrawal

Indexed keywords

ERGOTAMINE;

ANALGESIA; ANALGESIC ACTIVITY; CONFERENCE PAPER; DRUG ACTIVITY; DRUG EFFECT; DRUG WITHDRAWAL; HYPERALGESIA; MALE; MIGRAINE; MOTOR COORDINATION; MOUSE; NONHUMAN; PAIN THRESHOLD;

EID: 0031677801     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-H     Document Type: Conference Paper

References (8)

1. Bartolini, A., Malmberg, P., Bartolini, R., and Giotti, A. (1982). Effect of antimigraine drugs on nonopioid analgesia. Adv. Neurol. 33, 89-97.
2. Ghelardini, C., Galeotti, N., Donaldson, S., Nicolòdi, M., Sicuteri, F., and Bartolini, A. (1996a). Prevention by sumatriptan of hyperalgesia induced by morphine withdrawal. Fund. Clin. Pharmacol. 10, 192.
3. Ghelardini, C., Galeotti, N., and Figini, M. et al. (1996b). Central cholinergic system is responsible for antinociception induced in rodents and guinea-pigs by the antimigraine drug sumatriptan. J. Pharmacol. Exp. Ther. 279, 884-890.
4. O'Callaghan, J. P., and Holtzman, S. G. (1975). Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J. Pharmacol. Exp. Ther. 192, 497-505.
5. Raskin, N. H. (1981). Pharmacology of migraine. Annu. Rev. Pharmacol. Toxicol. 21, 463-478.
6. Sicuteri, F., Anselmi, B., Curradi, C., Michelacci, S., and Sassi, A. (1978). Morphine-like factors in CSF of headache patients. In The Endorphines, Adv. Biochem. Psychopharm. 18, ed. by E. Costa and M. Trabucchi, p. 363, Raven Press, New York.
7. Thompson, W. H. (1894). Ergot in the treatment of periodic neuralgias. J. Nerv. Ment. Dis. 19, 124-125.
8. Vaught, J. L., Pelley, K., Costa, L. G., Setler, L. G., and Enna, S. J. (1985). A comparison of the antinociceptive responses to GABA-receptor agonists THIP and baclofen. Neuropharmacology 24, 211-216.