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of outstanding interest. The presynaptic and postsynaptic effects of NT-4 overexpression by neurons and/or muscle in an artificial expression system (i.e. Xenopus nerve - muscle co-cultures) were studied by selectively recording from neural - myocyte synaptic pairs in which green fluorescent protein expression served as the indicator of NT-4 overexpression. The results show that NT-4 secreted from the postsynaptic muscle potentiates presynaptic transmitter release as well as enhancing muscle responses via a mechanism that increases the mean burst duration of ACh channels in the postsynaptic membrane. Interestingly, these effects are observed when NT-4 is overexpressed in muscle but not when it is overexpressed in neurons. These observations confirm the hypothesis that neurotrophins are important retrograde modulators of neuromuscular transmission.
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Wang XH, Poo M-m. Potentiation of developing synapses by postsynaptic release of neurotrophin-4. of outstanding interest Neuron. 19:1997;825-835 The presynaptic and postsynaptic effects of NT-4 overexpression by neurons and/or muscle in an artificial expression system (i.e. Xenopus nerve - muscle co-cultures) were studied by selectively recording from neural - myocyte synaptic pairs in which green fluorescent protein expression served as the indicator of NT-4 overexpression. The results show that NT-4 secreted from the postsynaptic muscle potentiates presynaptic transmitter release as well as enhancing muscle responses via a mechanism that increases the mean burst duration of ACh channels in the postsynaptic membrane. Interestingly, these effects are observed when NT-4 is overexpressed in muscle but not when it is overexpressed in neurons. These observations confirm the hypothesis that neurotrophins are important retrograde modulators of neuromuscular transmission.
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(1997)
Neuron
, vol.19
, pp. 825-835
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Wang, X.H.1
Poo M-M2
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44
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0030273379
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Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
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Schuster CM, Davis GW, Fetter RD, Goodman CS. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron. 17:1996;641-654.
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(1996)
Neuron
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Schuster, C.M.1
Davis, G.W.2
Fetter, R.D.3
Goodman, C.S.4
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45
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0030273550
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Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity
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Schuster CM, Davis GW, Fetter RD, Goodman CS. Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron. 17:1996;655-667.
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(1996)
Neuron
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Schuster, C.M.1
Davis, G.W.2
Fetter, R.D.3
Goodman, C.S.4
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46
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0029948786
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Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology
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Stewart BA, Schuster CM, Goodman CS, Atwood HL. Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology. J Neurosci. 16:1996;3877-3886.
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(1996)
J Neurosci
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Stewart, B.A.1
Schuster, C.M.2
Goodman, C.S.3
Atwood, H.L.4
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47
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0032485499
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Synapse-specific control of synaptic efficacy at the terminals of a single neuron
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of outstanding interest. By targeting specific identified muscles for overexpression of the cell adhesion molecule fasciclin II, the morphological and physiological characteristics of synaptic contacts on muscles overexpressing this protein can be compared with synaptic contacts from the same motoneuron made on adjacent control (non-overexpressing) muscles. The results show that changes in the number of synaptic contacts are compensated by changes in the efficacy of neuromuscular transmission, revealing a complicated signaling process in this neuromuscular system that coordinates morphology with physiology.
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Davis GW, Goodman CS. Synapse-specific control of synaptic efficacy at the terminals of a single neuron. of outstanding interest Nature. 392:1998;82-86 By targeting specific identified muscles for overexpression of the cell adhesion molecule fasciclin II, the morphological and physiological characteristics of synaptic contacts on muscles overexpressing this protein can be compared with synaptic contacts from the same motoneuron made on adjacent control (non-overexpressing) muscles. The results show that changes in the number of synaptic contacts are compensated by changes in the efficacy of neuromuscular transmission, revealing a complicated signaling process in this neuromuscular system that coordinates morphology with physiology.
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(1998)
Nature
, vol.392
, pp. 82-86
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Davis, G.W.1
Goodman, C.S.2
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