Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb

International Immunology

Volumn 10, Issue 12, 1998, Pages 1881-1889

  Autissier, Patrick ^a   De Vos, John ^a   Liautard, Janny ^a   Tupitsyn, Nikolai ^a,b   Jacquet, Chantal ^a   Chavdia, Natia ^a   Klein, Bernard ^a   Brochier, Jean ^a   Gaillard, JeanPhilippe ^a  

^a INSERM   (France)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Cellular activation; Cytokine receptors; FACS staining; Human; mAb

Indexed keywords

GLYCOPROTEIN GP 130; GROWTH FACTOR; INTERLEUKIN 6; MEMBRANE RECEPTOR; MONOCLONAL ANTIBODY; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DIMERIZATION; HYBRIDOMA; METASTASIS; MOUSE; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SIGNAL TRANSDUCTION;

EID: 0031675371     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.12.1881     Document Type: Article

References (15)

1. Kishimoto, T., Akira, S., Narazaki, M. and Taga, T. 1995. Interleukin6 family of cytokines and gp130. Blood 86:1243.
2. Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., Hirabayashi, T., Yoneda. Y., Tanaka, K., Wang, W.-Z., Mori, C., Shiota, K., Yoshida, N. and Kishimoto, T. 1996. Targeted disruption of gp130, a common signal transducer for the interleukin-6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl Acad. Sci. USA 93:407.
3. Liautard, J., Sun, R.-X., Cotte, N., Gaillard, J.-P., Mani, J.-C., Klein, B. and Brochier, J. 1997. Specific inhibition of IL-6 signaling with monoclonal antibodies against the gp130 receptor. Cytokine 9:233.
4. Wijdenes, J., Heinrich, P. C., Müller-Newen, G., Roche, C., Gu, Z. J., Clement, C. and Klein, B. 1995. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur. J. Immunol. 25:3474.
5. Gu, Z.-J., Wijdenes, J., Zhang, X.-G., Hallet, M.-M., Clement, C. and Klein, B. 1996. Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M. J. Immunol. Methods 190:21.
6. Autissier, P., Liautard, J., Brochier, J. and Gaillard. J. P. 1997. Activation of the gp130 signaling pathway by monoclonal antibodies directed against the gp130 molecule Eur. J. Immunol. 27:794.
7. Liautard, J., Gaillard, J. P., Mani, J. C., Montero-Julian, F., Duperray, C., Lu, Z. Y., Jourdan, M., Klein, B., Brailly, H. and Brochier, J. 1994. Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies. Eur. Cytokine Netw. 5:293.
8. Horvathova, M., Gaillard, J.-P., Liautard, J., Duperray, C., LavabreBertrand, T., Bourquard, P., Rossi, J.-F., Klein, B. and Brochier, J. 1995. Identification of novel and specific antigens of human plasma cells by mAb. In Leucocyte Typing V. White Cell Differentiation Antigens, p 713.
9. Sporeno, E., Savino, R., Ciapponi, L., Paonessa, G., Cabibbo, A., Lahm, A., Pulkki, K., Sun, R. X., Toniatti, C., Klein, B. and Ciliberto, G. 1996. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells. Blood 87:4510.
10. Zhang, X. G., Gaillard, J. P., Robillard, N., Lu, Z. Y., Gu, Z. J., Jourdan, M., Boiron, J. M., Bataille, R. and Klein. B. 1994, Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 83:3654.
11. Autissier, P., Liautard, J., Sun, R.-X., Cotte, N., Klein, B., Brochier. J. and Gaillard, J.-P. 1997. CD130 Workshop: activation of the gp130 signaling pathway by monoclonal antibodies directed against the gp130 molecule. In Leucocyte Typing VI. White Cell Differentiation Antigens, p. 845.
12. Hallek, M., Neumann, C., Schaffer, M., Danhauser-Riedl, S., von Bubnoff, N., de vos, G., Druker, B., Yasukawa, K., Griffin, J. and Emmerich, B. 1977. Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines. Exp. Hematol. 25:1367.
13. Fourcin, M., Chevalier, S., Guillet, C., Robledo, O., Froger, J., Pouplard-Barthelaix, A. and Gascan, H. 1996. gp 130 transducing receptor cross-linking is sufficient to induce Interleukin-6 type response. J. Biol. Chem. 271:11756.
14. Schneider, H., Chaopavong, W., Matthews, D. J., Karkaria, C., Cass, R. T., Zhan, H., Boyle, M., Lorenzini, T., Elliott, S. G. and Giebel, L. B. 1997. Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. Blood 89:473.
15. Suematsu, S., Matsusaka., T., Matsuda., T., Ohno, S., Miyasaki, J., Yamamura, K., Hirano, T. and Kishimoto, T. 1992. Generation of plasmacytomas with the chromosomal translocations t(12;5) in IL-6 transgenic mice. Proc. Natl Acad. Sci. USA 89:232.