Generation of chimeric monoclonal antibodies from mice that carry human immunoglobulin Cγ1 heavy or Cκ light chain gene segments

Journal of Immunological Methods

Volumn 215, Issue 1-2, 1998, Pages 27-37

  Pluschke, Gerd ^a   Joss, Andrea ^a   Marfurt, Jutta ^a   Daubenberger, Claudia ^a   Kashala, Oscar ^b   Zwickl, Markus ^c   Stief, Aribert ^c   Sansig, Gilles ^c   Schläpfer, Beatrice ^c   Linkert, Susanne ^c   Van Der Putten, Herman ^c   Hardman, Norman ^c   Schröder, Markus ^c  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b Aquila Biopharmaceuticals Inc   (United States)

^c CIBA GEIGY LTD   (Switzerland)

Author keywords

Chimeric antibodies; Immunoglobulin gene replacements

Indexed keywords

CHIMERIC ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; QS 21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE CONVERSION; GENE TARGETING; GENETIC TRANSCRIPTION; HYBRIDOMA; IMMUNOTHERAPY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERODIAGNOSIS; SPLEEN CELL; STEM CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BASE SEQUENCE; CLONING, MOLECULAR; EMBRYO; FEMALE; FLOW CYTOMETRY; GENE TARGETING; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; SPLEEN; STEM CELLS;

ANIMALIA;

EID: 0031671748     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(98)00041-6     Document Type: Article

References (18)

1. Allison, A.C., Byars, N.E., 1986. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity. J. Immunol. Methods 95, 157.
2. Brüggemann, M., Neuberger, M.S., 1996. Strategies for expressing human antibody repertoires in transgenic mice. Immunol. Today 17, 391.
3. Coughlin, R.T., Fattom, A., Chu, C., White, A.C., Winston, S., 1995. Adjuvant activity of QS-21 for experimental E. coli 018 polysaccharide vaccines. Vaccine 13, 17.
4. Glassy, M.C., 1993. Production methods for generating human monoclonal antibodies. Hum. Antibodies Hybridomas 4, 154.
5. Hardman, N., Murray, B., Zwickl, M., Kolbinger, F., Pluschke, G., 1992. Application of genetically-engineered anti-CEA antibodies for potential immunotherapy of colorectal cancer. Int. J. Biol. Markers 7, 203.
6. Hogan, B., Constantini, F., Lacy, E., 1986. Manipulating the Mouse Embryo. A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
7. Khazaeli, M.B., Conry, R.M., LoBuglio, A.F., 1994. Human immune response to monoclonal antibodies. J. Immunol. 15, 42.
8. Lonberg, N., Huszar, D., 1995. Human antibodies from transgenic mice. Int. Rev. Immunol. 13, 65.
9. Lopez, M.C., Silva, Y., Thomas, M.C., Garcia, A., Faus, M.J., Alonso, P., Martinez, F., Del Real, G., Alonso, C., 1994. Characterization of SPf(66)n: a chimeric molecule used as a malaria vaccine. Vaccine 12, 585.
10. Orlandi, R., Gussow, D.H., Jones, P.T., Winter, G., 1989. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86, 3833.
11. Patarroyo, M.E., Romero, P., Torres, M.L., Clavijo, P., Moreno, A., Martinez, A., Rodriguez, R., Guzman, F., Cabezas, E., 1987. Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature 328, 629.
12. Schläpfer, B., Scheibler, M., Holtorf, A.P., Nguyen, H.V., Pluschke, G., 1995. Development of optimized transfectoma cell lines for production of chimeric antibodies in hollow fiber cell culture systems. Biotechnol. Bioeng. 45, 310.
13. Stief, A., Texido, G., Sansig, G., Eibel, H., Le Gros, G., van der Putten, H., 1994. Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development. J. Immunol. 152, 3378.
14. Tanner, M., Teuscher, T., Alonso, P.L., 1995. SPf66 - the first malaria vaccine. Parasitol. Today 11, 10.
15. Thompson, K.M., 1988. Human monoclonal antibodies. Immunol. Today 9, 113.
16. Wood, S.A., Pascoe, W.S., Schmidt, C., Kemler, R., Evans, M.J., Allen, N.D., 1993. Simple and efficient production of embryonic stem cell-embryo chimeras by coculture. Proc. Natl. Acad. Sci. USA 90, 4582.
17. Zou, Y.R., Gu, H., Rajewsky, K., 1993. Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions. Science 262, 1271.
18. Zou, Y.R., Muller, W., Gu, H., Rajewsky, K., 1994. Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr. Biol. 4, 1099.