Role of the vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-α

Journal of Interferon and Cytokine Research

Volumn 18, Issue 9, 1998, Pages 721-729

  Shors, Scott T ^a,b   Beattie, Elizabeth ^c,d   Paoletti, Enzo ^c   Tartaglia, James ^c   Jacobs, Bertram L ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Virogenetics Corporation   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GENE PRODUCT;

ALPHA CHAIN; ANTIVIRAL ACTIVITY; ARTICLE; ENCEPHALOMYOCARDITIS VIRUS; HUMAN; HUMAN CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALIA; ENCEPHALOMYOCARDITIS VIRUS; VACCINIA; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 0031670373     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.721     Document Type: Article

References (38)

1. PESTKA, S., LANGER, J.A., ZOON, K.C., and SAMUEL, C.E. (1987). Interferons and their actions. Annu. Rev. Biochem. 56, 727-777.
2. DEMAEYER, E., and DEMAEYER-GUIGNARD, J. (eds.) (1988). Interferons and Other Cytokines. New York: John Wiley and Sons.
3. SAMUEL, C.E. (1988). Mechanisms of the antiviral action of interferons. Prog. Nucleic Acids Res. Mol. Biol. 35, 29-72.
4. HOVANESSIAN, A.G. (1991). Interferon-induced and double-stranded RNA activated enzymes: a specific protein kinase and 2′,5′-oligoadenylate synthetase. J. Interferon Res. 11, 199-205.
5. SAMUEL, C.E. (1991). Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183, 1-11.
6. SEN, G.C., and LENGYEL, P. (1992). The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem. 267, 5017-5020.
7. SEN, G.C., TAIRA, H., and LENGYEL, P. (1978). Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon-treated Ehrlich ascites tumor cells. J. Biol. Chem. 253, 5915-5921.
8. GALABRU, J., and HOVANESSIAN, A.G. (1987). Autophosphorylation of the protein kinase dependent on double-stranded RNA. J. Biol. Chem. 262, 15538-15544.
9. HOVANESSIAN, A.G., and GALABRU, J. (1987). The double-stranded RNA-dependent protein kinase is also activated by heparin. Eur. J. Biochem. 167, 467-473.
10. SAFER, B. (1983). 2B or not 2B: regulation of the catalytic utilization of elF-2. Cell 33, 7-8.
11. RATNER, L., WEIGAND, R., FARRELL, P., SEN, G.C., CABRER, B., and LENGYEL, P. (1978). Interferon, double-stranded RNA and RNA degradation. Biochem. Biophys. Res. Commun. 81, 947-954.
12. DOUGHERTY, J.P., SAMANTA, H., FARRELL, P.J., and LENGYEL, P. (1980). Interferon, double-stranded RNA, and RNA degradation. J. Biol. Chem. 255, 3813-3816.
13. n) from ATP. J. Biol. Chem. 255, 9807-9813.
14. n Proc. Natl. Acad. Sci. USA 76, 4778-4782.
15. FLOYD-SMITH, G., SLATTERY, E., and LENGYEL, P. (1981). Interferon action: RNA cleavage pattern of a (2′-5′)oligoadenylate-dependent endonuclease. Science 212, 1030-1032.
16. nA-dependent ribonuclease. Nature 289, 414-417.
17. KUMAR, R., CHOUBEY, D., LENGYEL, P., and SEN, G.C. (1988). Studies on the role of the 2′-5′-oligoadenylate syntheyase-RNase L pathway in β-interferon mediated inhibition of encephalomyocarditis virus replication. J. Virol. 62, 3175-3181.
18. COCCIA, E., ROMEO, G., NISSIM, A., MARIALI, G., ALBERTINI, R., AFFABRIS, E., BATTISTINI, A., FIORUCCI, G., ORSATTI, R., ROSSI, G., and CHEBATH, J. (1990). A full length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology 179, 228-233.
19. MEURS, E.F., WATANABE, Y., KADERIT, S., BARBER, G.N., KATZE, M.G., CHONG, K., WILLIAMS, B.R.G., and HOVANESSIAN, A.G. (1992), Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth. J. Virol. 66, 5805-5814.
20. HASSEL, B.A., ZHOU, A., SOTOMAYOR, C., MARAN, A., and SILVERMAN, R.H. (1993). A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12, 3297-304.
21. BAIER, L., SHORS, T., SHORS, S.T., and JACOBS, B.L. (1993). The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR. Nucleic Acids Res. 21, 4830-4835.
22. YOUNGNER, J.S., THACORE, H.R., and KELLEY, M.E. (1972). Sensitivity of ribonucleic acid and deoxyribonucleic acid viruses to different species of interferon in cell cultures. J. Virol. 10, 171-178.
23. BEATTIE, E., TARTAGLIA, J., and PAOLETTI, E. (1991). Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effects of interferon. Virology 183, 419-422.
24. BEATTIE, E., DENZLER, K., TARTAGLIA, J., PERKUS, M.E., PAOLETTI, E., and JACOBS, B.L. (1995). Reversal of the interferon-sensitive phenotype of an E3L-minus vaccinia virus by expression of the reovirus S4 gene. J. Virol. 69, 499-505.
25. DAVIES, M.V., ELROY STEIN, O., JAGUS, R., MOSS, B., and KAUFMAN, R.J. (1992). The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded RNA-activated protein kinase and phosphorylation of the a subunit of eukaryotic initiation factor 2. J. Virol. 66, 1943-1950.
26. DAVIES, M.V., CHANG, H.-W., JACOBS, B.L., and KAUFMAN, R.J. (1993). The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms. J. Virol. 67, 1688-1692.
27. CARROL, K., ELROY-STEIN, O., MOSS, B., and JAGUS, R. (1993). Recombinant vaccinia virus K3L gene product prevents activation of the double-stranded RNA-dependent, initiation factor 2 α-specific protein kinase. J. Biol. Chem. 268, 12837-12842.
28. WATSON, J.C., CHANG, H.-W., and JACOBS, B.L. (1991). Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase. Virology 185, 206-216.
29. CHANG, H.-W., WATSON, J., and JACOBS, B.L. (1992). The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 89, 4825-4829.
30. YUWEN, H., COX, J.H., YEWDELL, J.W., BENNINK, J.R., and MOSS, B. (1993). Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene. Virology 195, 732-744.
31. CHANG, H.-W., and JACOBS, B.L. (1993). Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA. Virology 194, 537-547.
32. WHITAKER-DOWLING, P., and YOUNGNER, J.S. (1983). Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity. Virology 131, 128-136.
33. WHITAKER-DOWLING, P., and YOUNGNER, J.S. (1986). Vaccinia-mediated rescue of encephalomyocarditis virus from the inhibitory effects of interferon. Virology 152, 50-57.
34. PERKUS, M.E., KAUFFMAN, E.B., TAYLOR, J., MERCER, S., SMITH, D., VANDERHOEVEN, J., and PAOLETTI, E. (1993). Methodology of using vaccinia virus to express foreign genes in tissue culture. J. Tissue Cult. Methods 15, 72-81.
35. r-66,000 subunits. J. Biol. Chem. 267, 10729-10736.
36. PATEL, R.C., STANTON, P., and SEN, G.C. (1994). Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin. J. Biol. Chem. 269, 18593-18598.
37. LEE, S.B., GREEN, S.R., MATHEWS, M.B., and ESTEBAN, M. (1994). Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vitro in the absence of its dsRNA binding domain. Proc. Natl. Acad. Sci. USA 91, 10551-10555.
38. DUBOIS, M., and HOVANESSIAN, A.G. (1990). Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection. Virology 179, 591-598.