The specificity of tyrosine kinase inhibitors: Their effect on insulin release (short-term effect) and insulin mRNA (long-term effect) in an insulin-secreting cell line (INS-1)

Experimental and Clinical Endocrinology and Diabetes

Volumn 106, Issue 4, 1998, Pages 292-298

  Neye, H ^a   Verspohl, E J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

INS 1; Insulin mRNA; Insulin release; Tyrosine kinase

Indexed keywords

DAIDZEIN; GENISTEIN; GENISTIN; INSULIN; LAVENDUSTIN A; MESSENGER RNA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; DRUG DEGRADATION; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031670179     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211988     Document Type: Article

References (30)

1. Abler A, Smith JA, Randazzo PA, Rothenberg PL, Jarett L: Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase. J Biol Chem 267: 3946-3951, 1992
2. Adlercreutz H. Phytoestrogens: epidemiology and a possible role in cancer protection. Envir Health Persp 103 (Suppl.): 103-112, 1995
3. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of tyrosine-specific protein kinases J Biol Chem 262: 5592-5595, 1987
4. Ammon HPT, Verspohl EJ: Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin. Endocrinology 99: 1469-1472, 1976
5. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differential insulin-secreting cell lines. Endocrinology 130: 167-178, 1992
6. Chan SJ, Noyes BE, Agarwal KL, Steiner DF: Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II. Proc Natl Acad Sci USA 76: 5035-5040, 1979
7. Chomszynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987
8. Dunbar JC, McLaughlin WJ, Walsh MF, Foà PP: Insulin secretion and glucose uptake by isolated islets of the hamster. Effect of insulin, proinsulin, and C-peptide. Horm Metab Res 8: 1-6, 1976
9. Gazit A, Yaish P, Gilon C, Levitzki A: Tyrphostins I: Synthesis and biological activity of protein kinase inhibitors. J Med Chem 32: 2344-2352, 1989
10. Giudice LC, de Zegher F, Gargosky SE, Dsupin BA, de las Fuentes L, Crystal RA, Hintz RL, Rosenfeld RG: Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab 80, 1548-1555, 1995
11. Higashi K, Ogawara H. Daidzein inhibits insulin- or IGF-1-mediated signaling in cell cycle progression of Swiss3T3 cells. Biochimica Biophys Acta 1221: 29-35, 1994
12. Hunter T: A thousand and one protein kinases. Cell 50: 823-829, 1987
13. Iversen J, Miles DW: Evidence for feedback inhibition of isulin on insulin secretion in the isolated, perfused canine pancreas. Diabetes 20: 1-9, 1971
14. Jonas JC, Plant TD, Gilon P, Detimary P, Henquin M, Henquin JC: Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets. Br J Pharmacol 114: 872-880, 1995
15. Koranyi L, James DE, Kraegen EW, Permutt MA: Feedback inhibition of insulin gene expression by insulin. J Clin Invest 89: 432-436, 1992
16. Levitzki A, Gazit A: Tyrosine kinase inhibition: An approach to drug development. Science 267: 1782-1787, 1995
17. Ohno T, Kato N, Ishii C, Shimizu M, Ito Y, Tomono S, Kawazu S: Genistein augments cAMP accumulation and insulin release in MIN6 cells. Endocrine Res 19: 273-285, 1993
18. Onoda T, Inuma H, Sasaki Y, Hamada M, Isshiki K, Naganawa N, Takeuchi T: Isolation of a novel tyrosine kinase inhibitor, Lavendustin A. from Streptomyces griseolavendus. J Nat Prod 52: 1252-1257, 1989
19. Philippe J: Somatostatin inhibits insulin-gene expression through a posttranscriptional mechanism in a hamster islet cell line. Diabetes 42: 244-249, 1993
20. Philippe J, Missotten M: Functional characterization of a cAMP-responsive element of the rat insulin I gene. J Biol Chem 265: 1465-1469, 1990
21. Philippe J, Pacheco I, Meda P: Insulin gene transcription is decreased rapidly by lowering glucose concentrations in rat islet cells. Diabetes 43: 523-528, 1994
22. Schatz H, Pfeiffer EF: Release of immunoreactive and radioactively prelabelled endogenous (pro-)insulin from isolated islets of rat pancreas in the presence of exogenous insulin. J Endocrinol 74: 243-248, 1977
23. Schuppin GT, Rhodes CJ: Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochemical J 313: 259-268, 1996
24. Sorenson RL, Brelje TC, Roth C: Effect of tyrosine kinase inhibitors on islets of Langerhans: evidence for tyrosine kinases in the regulation of insulin secretion. Endrocrinology 134: 1975-1978, 1994
25. van Schravendijk CFH, Heylen L, van den Brande JL, Pipeleers DG: Direct effect of insulin and IGF-I on the secretory activity of rat pancreatic beta cells. Diabetologia 33: 649-653, 1990
26. Verspohl EJ, Tollkühn B, Kloss H: Role of tyrosine kinase for insulin release in an insulin secreting cell line (INS-1). Cell Sign 7: 505-512, 1995
27. Verspohl EJ, Ammon HPT: Evidence for presence of insulin receptors in rat islets of Langerhans. J Clin Invest 65: 1230-1237, 1980
28. Wang Y, Egan JM, Raygada M, Nadiv O, Roth J, Montrose-Rafizadeh C: GLP-1 affects gene transcription and mRNA stability of components of the insulin secretory system in RIN 1046-38 cells. Endocrinology 136: 4910-4917, 1995
29. Welsh M, Nielsen DA, MacKrell AJ, Steiner DF: Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells: II. Regulation of insulin mRNA stability. J Biol Chem 260: 13590-13594, 1985
30. Young SW, Poole RC, Hudson AT, Halestrap AP, Denton RM, Tavare JM: Effects of tyrosine kinase inhibitors on protein kinase-independent systems. FEBS Lett 316: 278-282, 1993