The value of prostate specific antigen (PSA) density and free: Total PSA ratio in selecting patients with a normal digital rectal examination and intermediate total PSA levels for further investigation

British Journal of Urology

Volumn 82, Issue 3, 1998, Pages 393-397

  Klingler, H C ^a,b   Woo, H ^a   Rosario, D ^a   Cutinha, P E ^a   Anderson, J ^a   Ward, A M ^a   Chapple, C R ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Diagnosis; Free to total; Prostate cancer; PSA; Ratio

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

AGED; ARTICLE; CONTROLLED STUDY; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; RECTUM; STATISTICAL ANALYSIS;

AGED; DIAGNOSIS, DIFFERENTIAL; HUMANS; MALE; PATIENT SELECTION; PHYSICAL EXAMINATION; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0031669607     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.1998.00761.x     Document Type: Article

References (28)

1. Muller Jensen 0. Esteve J, Moller H, Renard H. Cancer in the European community and its member states. Eur ] Cancer 1990; 25: 1167-256
2. Catalona WJ, Smith DS, Ratliff TL et al. Detection of organconfined prostate cancer is increased through prostate specific antigen based screening. JAMA 1993; 270: 948-54
3. Catalona WJ, Richie JP, Ahmann FR et al Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicentre clinical trial of 6630 men. J Urol 1994: 151: 1283-90
4. Cooner WH. Mosley BR, Rutherford CL Jr et al. Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen. J Urol 1990; 143: 1146-62
5. Littrup PJ, Goodman AC, Mettlin CJ. The benefit and cost of prostate cancer early detection. The investigators of the American Cancer Society. National Prostate Cancer Detection Project. CA Cancer J Clin 1993; 43: 134-49
6. Blackwell KL, Bostwick DG, Myers RP et al. Combining prostate specific antigen with cancer and gland volume to predict more reliably pathological stage: the influence of prostate specific antigen cancer density. J Urol 1994: 151: 1565-70
7. Oesterling JE, Martin SK. Bergstrahl EJ et al. The use of prostate-specific antigen in staging patients with newly diagnosed prostate cancer. JAMA 1993; 269: 57-60
8. Stamey TA, Kabalin JN, McNeal JE et al. Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. J Urol 1989; 141: 1076-83
9. Waehre H, Wanderaas EH, Paus E et al. Prediction of lymph node métastases by prostate specific antigen and prostate acid phosphatase in clinical T3 14 MO prostatic cancer. Eur Urol 1992; 22: 33-8
10. Brawer MK, Aramburu BAG, Chen GL et al. The inability of prostate specific antigen index to enhance the predictive value of prostate specific antigen in the diagnosis of prostate carcinoma. J Urol 1993; 150: 369-73
11. Benson MC, Whang IS, Pantuck A et al. Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J Urol 1992: 147: 815-6
12. Benson MC. Whang IS. Pantuck A et al. The use of Prostate specific antigen density to enhance the predictive value of intermediate levels of prostate specific antigen. J Urol 1992: 147: 817-21
13. Epstein JI. Walsh PC. Brendler CB. Radical prostatectomy for impalpable prostate cancer: the John Hopkins experience with tumours found on transurethral resection (stages Tla & Tib) and on needle biopsy (stage Tic). J Urol 1994: 152: 1721-9
14. Shinohara K, Wolf JS Jr. Narayan P et al. Comparison of prostate specific antigen density for 3 clinical applications. J Urol 1994: 152: 120-3
15. Stenman UH, Leinonen J. Alfan H. Rannikko S. Tuhkanen K, Alfthan 0. A complex between prostate specific antigen and alpha-antichymotrypsin is the major form of prostate specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991: 51: 222-6
16. Christensson A. Bjork T, Nilsson 0 Dahlen U et al. Serum prostate specific antigen complexed to alphaantichymotrypsin as an indicator of prostate cancer. J Urol 1993; 150: 100-5
17. Leinonen J. Lovgren T, Vornanen T et al. Double-label timeresolved immunofluorometric assay of prostate specific antigen and of its complex with alpha-antichymotrypsin. Clin Chem 1993; 39: 2098-103
18. Luderer AA. Chen YT. Soriano TF el al. Measurement of the proportion of free to total prostate specific antigen improves diagnostic performance of prostate specific antigen in the diagnostic grey zone of total prostate specific antigen. Urology 1995: 46: 187-94
19. Oesterling JE. Jacobson SJ. Chute CG et al. Serum prostate specific antigen in a community based population of healthy men. Establishment of age specific reference ranges. JAMA 1993: 270: 860
20. Carter HB. Pearson JD. Metter EJ et al. Longitudinal evaluation of PSA levels in men with and without prostate disease. JAMA 1992: 267: 2215-20
21. American Cancer Society. National Prostate Cancer Detection Project. The results of a 5 year Early Prostate Cancer Detection Intervention. Camer 1996; 77: 150-9
22. Thon WF. Gadban F. Truss MC. Kuczyk M. Hartmanan U. Jonas U. Prostate specific antigen density -a reliable parameter for the detection of prostate cancer. World ] Urol 1996: 14: 53-8
23. Catalona WJ. Smith DS. Wolfert RL et al. Evaluation of percentage of free serum prostate specific antigen to improve specificity of prostate cancer screening. JAMA 1995: 274: 1214-20
24. Chen Y, Luderer AA. Thiel RP et al. Using proportions of free to total prostate-specific antigen, age. and total prostate-specific antigen to predict the probability of prostate cancer. Urology 1996: 47: 518-24
25. Cooner WH. Prostate specific antigen, digital rectal examination, and transrectal ultrasonic examination of the prostate cancer detection. Mongraph Urol 1991: 13: 3
26. Catalona WJ. Richie JP. deKernion JB et al. Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves. J L'rol 1994: 152: 2046-8
27. Stephan C, Jung K. Lein M et al. The ratio of free to total prostate specific antigen is correlated to prostate volume. Int l Cancer 1996: 67: 461-2 /
28. Prestigiacomo AA. Lilja H. Pettersson K ft al. A comparison of the free fraction of serum prostate specific antigen in men with benign and cancerous prostates: the best case scenario. J Urol 1996: 156: 50-4