The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl

British Journal of Anaesthesia

Volumn 81, Issue 4, 1998, Pages 598-600

  Palkama, Vilja J ^a   Neuvonen, Pertti J ^a   Olkkola, Kiaus T ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Analgesics opioid; Cytochrome 3A; Enzymes; Fentanyl; Itraconazole; Pharmacokinetics; Pharmacology

Indexed keywords

ANTIFUNGAL AGENT; FENTANYL; ITRACONAZOLE; NARCOTIC ANALGESIC AGENT; OXYGEN;

ARTICLE; BLOOD OXYGEN TENSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DROWSINESS; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; NAUSEA; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PRIORITY JOURNAL; PRURITUS; RADIOIMMUNOASSAY;

EID: 0031669538     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.4.598     Document Type: Article

References (6)

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5. Olkkola KT, Ahonen J, Neuvonen PJ. The effect of the systemic antimycotics itraconazole and fluconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam. Anesthesia and Analgesia 1996; 82: 511-516.
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