2 Barrier-1 site pore: An interactive spreadsheet model for two permeating ions

Computers in Biology and Medicine

Volumn 28, Issue 3, 1998, Pages 255-273

  Mansoura, Monique K ^a,b   Dawson, David Charles ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Electrophysiology; Energy barrier profile; Eyring rate theory; Ion channel; Pore model; Spreadsheet

Indexed keywords

ION CHANNEL;

ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; ION PERMEABILITY; PRIORITY JOURNAL;

ALGORITHMS; COMPUTER GRAPHICS; COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; ELECTROCHEMISTRY; FEEDBACK; HUMANS; ION CHANNEL GATING; ION CHANNELS; MODELS, CHEMICAL; PERMEABILITY; SOFTWARE; USER-COMPUTER INTERFACE;

EID: 0031668533     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-4825(98)00006-7     Document Type: Article

References (26)

1. H. Eyring, R. Lumry et al, Some applications of modern rate theory to physiological systems, Rec. Chem. Prog. 10 (1949) 100.
2. D.C. Dawson, Permeability and conductance in ion channels: a primer, in: S.G. Schultz, T.E. Andreoli, A.M. Brown, D.M. Fambrough, J.F. Hoffman, M.J. Welsh (Eds.), Molecular Biology of Membrane Transport Disorders, Plenum Press, New York, 1996, pp. 87-110.
3. J.A. Dani, Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations, Biophys. J. 49 (1986) 607.
4. J.A. Dani, D.G. Levitt, Diffusion and kinetic approaches to describe permeation in ionic channels, J. Theor. Biol. 146 (1990) 289.
5. D.C. Dawson, Principles of membrane transport, in: S.G. Schultz, M. Field, R.A. Frizzell (Eds.), Handbook of Physiology. Gastrointestinal Physiology, sect. 6, vol. IV, Am. Physiological Society, Bethesda, MD, 1991, ch. 1, pp. 1-44.
6. G. Eisenman, R. Horn, Ionic selectivity revisited: the role of kinetic and equilibrium processes in ion permeation through channels, J. Membr. Biol. 76 (1983) 197.
7. B. Hille, Ionic Channels of Excitable Membranes, 2nd ed., Sinauer Associates, Sunderland, MA, 1992.
8. P. Läuger, Ion transport through pores: a rate-theory analysis, Biochim. Biophys. Acta 311 (1973) 423.
9. H.A. Lester, Strategies for studying permeation at voltage-gated ion channels, Annu. Rev. Physiol. 53 (1991) 477.
10. +-selective channel from sarcoplasmic reticulum, J. Gen. Physiol. 76 (1980) 425.
11. B. Hille, W. Schwarz, Potassium channels as multi-ion single-file pores, J. Gen. Physiol. 72 (1978) 409.
12. + channels, Biophys. J. 66 (1994) 1929.
13. R.J. French, J.F.R. Worley et al., Ion permeation, divalent ion block, and chemical modification of single sodium channels. Description by single- and double-occupancy rate-theory models, J. Gen. Physiol. 103 (1994) 447 (published erratum appears in J. Gen. Physiol. 103(5) (1994) 937).
14. B. Hille, Ionic selectivity, saturation, and block in sodium channels. A four-barrier model, J. Gen. Physiol. 66 (1975) 535.
15. A.M. Woodhull, Ionic blockage of sodium channels in nerve, J. Gen. Physiol. 61 (1973) 687.
16. D.L. Campbell, R.L. Rasmusson et al, Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single calcium channels. New insights into the characterization of multi-ion channels, Biophys. J. 54 (1988) 945.
17. P. Hess, R.W. Tsien, Mechanism of ion permeation through calcium channels, Nature 309 (1984) 453.
18. 2+ channel pore in rat phaeochromocytoma cells, J. Physiol. 466 (1993) 657.
19. F. Franciolini, W. Nonner, A multi-ion permeation mechanism in neuronal background chloride channels, J. Gen. Physiol. 104 (1994) 725.
20. D.R. Halm, R.A. Frizzell, Anion permeation in an apical membrane chloride channel of a secretory epithelial cell, J. Gen. Physiol. 99 (1992) 339.
21. J.L. Overholt, M.E. Hobert et al, On the mechanism of rectification of the isoproterenol-activated chloride current in guinea-pig ventricular myocytes, J. Gen. Physiol. 102 (1993) 871.
22. J.L. Overholt, A. Saulino et al, Rectification of whole cell cystic fibrosis trans-membrane conductance regulator chloride current, Am. J. Physiol. 268 (1995) C636.
23. - channel from Torpedo electroplax, J. Gen. Physiol. 78 (1981) 1.
24. P. Linsdell, J.A. Tabcharani, J.W. Hanrahan, Multi-ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel, J. Gen. Physiol. 110 (1997) 365.
25. D. Chen, L. Xu et al, Permeation through the calcium release channel of cardiac muscle, Biophys. J. 73 (1997) 1337.
26. C. Labarca, M.W. Nowak et al, Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors, Nature 376 (1995) 514.