Metabolic fate of TAT-59(1st report) - Absorption, distribution, excretion and transfer to fetus and milk of 14C-TAT-59 after oral administration to rats

Japanese Pharmacology and Therapeutics

Volumn 26, Issue 4, 1998, Pages 76-77

  Yoshida, Masahiko ^a   Masuda, Hirotoshi ^a   Ikeda, Kazumasa ^a   Nagayama, Sekio ^a   Kawaguchi, Yasuro ^a   Nozaki, Osamu ^b   Hirao, Ryuichi ^b   Nishimori, Tsukao ^b  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b Environmental Biological Life Science Research Center Inc   (Japan)

Author keywords

Absorption; Distribution; Excretion; Miproxifene phosphate; Rat; TAT 59

Indexed keywords

CARBON 14; DIMETHYLBENZ[A]ANTHRACENE; MIPROXIFENE PHOSPHATE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG MILK LEVEL; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG URINE LEVEL; FEMALE; LACTATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRENATAL DRUG EXPOSURE; RAT;

EID: 0031668139     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Toko T et al: TAT-59, a new triphenyl-ethylene derivative with antitumor activity against hormone-dependent tumors. Cancer Chemother Pharmacol 37: 7-13, 1995
2. Iino Y et al: A new triphenylethylene derivative, TAT-59 ; Hormone receptors: Insulin-like growth factor 1 ; And growth suppression of hormone-dependent MCF-7 tumors in athymic mice. Cancer Chemother Pharmacol 34: 372-376, 1994