Activated hepatic stellate cells participate in liver fibrosis in a patient with transfusional iron overload

Journal of Gastroenterology

Volumn 33, Issue 5, 1998, Pages 751-754

  Harada, Yoshinori ^a   Iwai, Masaki ^a   Kakusui, Masamichi ^a   Mori, Takahiro ^a   Tada, Kazunobu ^a   Ishii, Yasutaka ^a   Okanoue, Takeshi ^a   Kashima, Kei ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Hepatic stellate cell; Iron; Liver fibrosis; Transfusion

Indexed keywords

ALPHA ACTIN; COLLAGEN FIBER; FERRITIN; HLA A ANTIGEN; HLA A2 ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; IRON;

ADULT; ARTICLE; BLOOD TRANSFUSION; CASE REPORT; CELL ACTIVATION; CELL INFILTRATION; CHRONIC KIDNEY FAILURE; COMPUTER ASSISTED TOMOGRAPHY; ELECTRON MICROSCOPY; FERRITIN BLOOD LEVEL; FIBROGENESIS; HEMOCHROMATOSIS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON OVERLOAD; KUPFFER CELL; LAPAROSCOPY; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; MYOFIBROBLAST; PORTAL VEIN; PRIORITY JOURNAL; STELLATE CELL;

ADULT; BLOOD TRANSFUSION; DIAGNOSIS, DIFFERENTIAL; HUMANS; IRON OVERLOAD; LIVER; LIVER CIRRHOSIS; MALE;

EID: 0031667515     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350050168     Document Type: Article

References (21)

1. Rouault TA. Hereditary hemochromatosis. JAMA 1993;269: 3152-3154.
2. Niederau C, Fischer R, Purschel A, et al. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-1119.
3. Kothari T, Swamy AP, Lee CK, et al. Hepatic hemosiderosis in maintenance hemodialysis patients. Dig Dis Sci 1980;25: 363-368.
4. Schafer AI, Cheron RG, Dluhy R, et al. Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med 1981;304:319-324.
5. Ali M, Fayemi AO, Rigolosi R, et al. Hemosiderosis in hemodialysis patients. JAMA 1980;244:343-345.
6. Arthur MJP. Iron overload and liver fibrosis. J Gastroenterol Hepatol 1996;11:1124-1129.
7. Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin Liver Dis 1996;16:13-30.
8. Friedman SL. The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies. N Engl J Med 1993;328:1828-1835.
9. Ramm GA, Powell LW, Hallday JW. Hepatic stellate cell activation in genetic hemochromatosis lobular distribution; effect of increasing hepatic iron and response to phlebotomy (abstract). Hepatology 1995;22:279.
10. Schmitt-Graff A, Kruger S, Bochard F, et al. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 1991;138: 1233-1242.
11. Chezmar JL, Nelson RC, Malko JA, et al. Hepatic iron overload; diagnosis and quantification by non-invasive imaging. Gastrointest Radiol 1990;15:27-31.
12. Howard JM, Ghent CN, Carey LS, et al. Diagnostic efficacy of hepatic computed tomography in the detection of body iron overload. Gastroenterology 1983;84:209-215.
13. Stal P. Iron as a hepatotoxin. Dig Dis 1995;13:205-222.
14. Bacon BR, Britton RS. The pathology of hepatic iron overload: A free radical-mediated process? Hepatology 1990;11:127-137.
15. Bacon BR, Tavill AS, Brittenham GM, et al. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 1983;71:429-439.
16. Yokoi Y, Namihisa T, Matsuzaki K, et al. Distribution of Ito cells in experimental hepatic fibrosis. Liver 1988;8:48-52.
17. Enzan H, Himeno H, Iwamura S, et al. Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis. Virchows Arch B Cell Pathol 1995;426:95-101.
18. Okanoue T, Burbige EJ, French SW. The role of Ito cell in perivenular and intralobular fibrosis in alcoholic hepatitis. Arch Pathol Lab Med 1983;109:459-463.
19. Pietrangelo A, Montosi G, Garuti C, et al. Molecular and cellular aspects of liver disease in genetic hemochromatosis (abstract). Hepatology 1995;22:371.
20. Gressner AM, Kawakita N, Polzar B, et al. TGF-β activates hepatic stellate cells by induction of apoptosis of hepatocytes in culture (abstract). J Hepatol 1995;23:76.
21. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: Implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 1990;11:599-605.