HLA-A26 subtype A pockets accommodate acidic N-termini of ligands

Immunogenetics

Volumn 48, Issue 5, 1998, Pages 350-353

  Dumrese, Tilman ^a   Stevanović, Stefan ^a   Seeger, Florian H ^a   Yamada, Natsue ^b,e   Ishikawa, Yoshihide ^c   Tokunaga, Katsushi ^d   Takiguchi, Masafumi ^b,e   Rammensee, Hans Georg ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPANESE RED CROSS MEDICAL CENTER   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

HLA; MHC ligands; Peptide motif; Pockets; TFA extraction

Indexed keywords

HLA A ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; GENETIC TRANSFECTION; HLA SYSTEM; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ALLELES; HLA-A ANTIGENS; HUMANS; LIGANDS; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; POLYMORPHISM, GENETIC; PROTEIN BINDING;

EID: 0031667292     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050443     Document Type: Article

References (14)

1. Barber, L.D., Percival, L., Arnett, K.L., Gumperz, J.E., Chen, L., and Parham, P. Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity. J Immunol 158: 1660-1669, 1997
2. Barnstable, C.J., Bodmer, W.F., Brown, G., Galfre, C., Milstein, C., Williams, A.F., and Ziegler, A. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens - new tools for genetic analysis. Cell 14: 9-20, 1978
3. Barouch, D., Friede, T., Stevanović S., Tussey, L., Smith, K., Rowland-Jones, S., Braud, V., McMichael, A., and Rammensee, H.-G. HLA-A2 subtypes are functionally distinct in peptide binding and presentation. J Exp Med 182: 1847-1856, 1995
4. DiBrino, M., Parker, K.C., Margulies D.H., Shiloach, J., Turner, R.V., Biddison, W.E., and Coligan, J.E. The HLA-B14 peptide binding site can accommodate peptides with different combinations of anchor residues. J Biol Chem 269: 32426-32434, 1994
5. Falk, K., Rötzschke, O., Stevanović S., Jung, G., and Rammensee, H.-G. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351: 290-296, 1991
6. Falk, K., Rötzschke, O., Takiguchi, M., Grahovac, B., Gnau, V., Stevanović S., Jung, G., and Rammensee, H.-G. Peptide motifs of HLA-A1, -A11, -A31, and -A33 molecules. Immunogenetics 40: 238-241, 1994
7. Falk, K., Rötzschke, O., Takiguchi, M., Gnau, V., Stevanović S., Jung, G., and Rammensee, H.-G. Peptide motifs of HLA-B38 and B39 molecules. Immunogenetics 41: 162-164, 1995a
8. Falk, K., Rötzschke, O., Takiguchi, M., Gnau, V., Stevanović S., Jung, G., and Rammensee, H.-G. Peptide motifs of HLA-B51,- B52 and -B78 molecules, and implications for Behcet's disease. Int Immunol 7: 223-228, 1995b
9. Guo, H.C., Jardetzky, T.S., Garrett T.P., Lane, W.S., Strominger, J.L., and Wiley, D.C. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature 360: 364-366, 1992
10. Jardetzky, T.S., Lane, W.S., Robinson, R.A., Madden, D.R., and Wiley, D.C. Identification of self peptides bound to to purified HLA-B27. Nature 353: 326-329, 1991
11. Neisig, A., Wubbolts, R., Zang, X., Melief, C., and Neefjes, J. Allele specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. J Immunol 156: 3196-3206, 1996
12. Rammensee, H.G., Bachmann, J., Stevanović S. MHC ligands and peptide motifs, Landes Bioscience, Georgetown, Tex., 1997
13. Seeger, F.H., Arnold, D., Dumrese, T., de la Salle, H., Fricker, D., Schild, H., Rammensee, H.G., and Stevanović S. The HLA-B*1516 motif indicates HLA-B specific P2 pocket characteristics. Immunogenetics 48: 156-160, 1998
14. Stevanović S. Multiple sequence analysis of MHC ligands. In I. Lefkovits (ed.): Immunology methods manual, pp. 589-602, Academic Press, San Diego, 1997