Hyperammonemia and coma developed by a woman treated with valproic acid for affective disorder

Psychiatric Services

Volumn 49, Issue 10, 1998, Pages 1358-1359

  Eze, Emmanuel ^a,b   Workman, Marc ^c   Donley, Brian ^a  

^a Three Rivers Medical Center   (United States)

^b Mountain Comprehensive Care Center   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; AMMONIA; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; CLONIDINE; GLUCOSE; LACTULOSE; NALOXONE; SERTRALINE; TRANQUILIZER; TRAZODONE; VALPROIC ACID;

AFFECTIVE NEUROSIS; AGED; ANXIETY NEUROSIS; ARTICLE; CASE REPORT; COMA; DEPRESSION; DRUG DEPENDENCE; FEMALE; HUMAN; HYPERAMMONEMIA;

EID: 0031666984     PISSN: 10752730     EISSN: None     Source Type: Journal    
DOI: 10.1176/ps.49.10.1358     Document Type: Article

References (6)

1. Duarte J, Marcias S, Coria F, et al: Valproate-induced coma: case report and literature review. Annals of Psychotherapy 27: 582-583, 1993
2. Leao M: Valproate as a cause of hyperammonemia in heterozygotes with ornithine transcarbamoylase deficiency. Neurology 45:593-594, 1995
3. Hjelm M, Oberholzer V, Seakins J, et al: Valproate-indueed inhibition of urea synthesis and hyperammonemia in healthy subjects (ltr). Lancet 2:859, 1986
4. Honeycutt D, Callahan K, Rutledge L, et al: Heterozygote ornithine transcarbamoylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy. Neurology 42:666-668, 1992
5. Settle EC Jr: Valproic acid-associated encephalopathy with coma (ltr). American Journal of Psychiatry 152:1236-1237, 1995
6. Krishnan KRR, Steffens DC, Doraiswamy PM: Psychotropic Drug Interactions. New York, MBL Communications, 1996