Glutamine and liver cells: Metabolism, properties and metabolic regulation by cell swelling;Glutamine et cellule hepatique: metabolisme, proprietes et concept de regulation du metabolisme par le gonflement cellulaire

Annales de Biologie Clinique

Volumn 56, Issue 5, 1998, Pages 557-562

  Lavoinne, A ^a   Husson, A ^a   Quillard, M ^a  

^a UFR Medecine Pharmacie   (France)

Author keywords

Cell swelling; Glutamine; Liver

Indexed keywords

BETA ACTIN; ENZYME; GLUCOSE; GLUTAMINE; GLYCOGEN; LIPID; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SODIUM ION; ACTIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); SODIUM;

ARTICLE; CELL SWELLING; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHESIS; LIPOGENESIS; LIVER CELL; LIVER METABOLISM; METABOLIC REGULATION; METABOLISM; ANIMAL; CELL SIZE; CYTOLOGY; GENETICS; GLYCOGEN LIVER LEVEL; HOMEOSTASIS; HUMAN; LIPID METABOLISM; LIVER; OSMOLARITY; PHYSIOLOGY; REVIEW;

ACTINS; ANIMALS; CELL SIZE; GENE EXPRESSION REGULATION; GLUTAMINE; HOMEOSTASIS; HUMANS; LIPID METABOLISM; LIVER; LIVER GLYCOGEN; OSMOLAR CONCENTRATION; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); SODIUM;

EID: 0031666826     PISSN: 00033898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Häussinger D. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem 1983 ; 133 : 269-75.
2. Sies H, Häussinger D. Hepatic glutamine and ammonia metabolism : nitrogen and redox balance and the intercellular glutamine cycle. In : Glutamine metabolism in mammalian tissues (Häussinger D & Sies H, eds), Springer-Verlag Berlin Heidelberg, 1984 : 78-97.
3. Lavoinne A, Baquet A, Hue L. Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat hepatocytes. Biochem J 1987 ; 248 : 429-37.
4. Caro LH, Plomp PJ, Leverve X, Meijer AJ. A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes. Eur J Biochem 1989 ; 181 : 717-20.
5. Quillard M, Renouf S, Husson A, Meisse D, Lavoinne A. Glutamine and regulation of gene expression in mammalian cells : special reference to phosphoenolpyruvate carboxykinase (PEPCK). Biochimie 1997 ; 79 : 125-8.
6. Häussinger D. The role of cellular hydration in the regulation of cell function. Biochem J 1996 ; 313 : 697-710.
7. Hue L, Gaussin V, Lavoinne A, Meijer AJ. Régulation du métabolisme hépatique par le gonflement cellulaire. Médecine/Sciences 1995 ; 11 : 1243-9.
8. Hue L, Gaussin V, Krause U. Anabolic response to cell swelling in the liver. In : Contribution of physiology to the understanding of diabetes (Vahnd GR & Wollheim CB, eds), Springer Verlag Berlin, 1997 : 10-23.
9. Kilberg MS, Handlogten ME, Christensen HN. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine and closely related analogs. J Biol Chem 1980 ; 255 : 4011-9.
10. Bode B, Tamarappoo BK, Mailliard M, Kilberg. Characteristics and regulation of hepatic glutamine transport. J Parenter Enter Nutr 1990 ; 14 : 51S-5.
11. Souba WW. Glutamine and the liver. In : Glutamine : physiology, biochemistry und nutrition in critical illness (Souba WW, ed) CRC Press, Boca Raton, Florida, 1992 : 35-39.
12. McGivan JD, Bradford NM, Verhoeven AJ, Meijer AJ. Liver glutaminase. In : Glutamine metabolism in mammalian tissues (Häussinger D & Sies H, eds), Springer-Verlag Berlin Heidelberg, 1984 : 122-37.
13. Mouterde O, Claeyssens S, Chédeville A, Lavoinne A. Glulamine is a good substrate for glycogen synthesis in isolated rat hepatocytes from 72 h-starved rats, but not from 24 h-or 48 h-starved rats. Biochem J 1992 ; 288 : 795-9.
14. Meister A. Enzymology of glutamine. In : Glutamine metabolism in mammalian tissues (Häussinger D & Sies H, eds), Springer-Verlag Berlin Heidelberg, 1984 : 3-15.
15. Graf J, Haddad P, Haussinger D, Lang F. Cell volume regulation in liver. Renal Physiol Biochem 1988 ; 3-5 : 202-20.
16. McCarty NA, O'Neil RG. Calcium signaling in cell volume regulation. Physiol Rev 1992 ; 72 : 1037-61.
17. Hue L, Bontemps F, Hers HG. The effect of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations. Biochem J 1975 ; 152 : 105-14.
18. Katz J, Golden S, Wals PA. Stimulation of hepatic glycogen synthesis by amino acids. Proc Natl Acad Sci USA 1976 ; 73 : 3433-7.
19. Okajima F, Katz J. Effects of mercaptopicolinic acid and of transaminase inhibitors on glycogen synthesis by rat hepatocytes. Biochem Biophys Res Commun 1979 ; 87 : 155-62.
20. Rognstad R. Effects of amino acid analogs and amino acid mixtures on glycogen synthesis in rat hepatocytes. Biochem Arch 1986 ; 2 : 185-90.
21. Baquet A, Hue L, Meijer AJ, van Woerkom GM, Plomp PJAM. Swelling of rat hepatocytes stimulates glycogen synthesis. J Biol Chem 1990 ; 265 : 955-9.
22. Baquet A, Maisin L, Hue L. Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase. Biochem J 1991 ; 278 : 887-90.
23. Cai JW, Hughes CS, Shen JW, Subjeck JR. Induction of heat-shock proteins by glutamine: the feeding effect. FEBS Lett 1991 ; 288 : 229-32.
24. Theodoropoulos PA, Stournaras C, Stoll B, et al. Hepatocyte swelling leads to rapid decrease of the G-/total actin ration and increases actin mRNA levels. FEBS Lett 1992 ; 311 : 241-5.
25. Warskulat U, Newsome W, Noe B, Stoll B, Häussinger D. Anisoosmotic regulation of hepatic gene expression. Biol Chem Hoppe-Seyler 1996 ; 377 : 57-65.
26. Quillard M, Husson A, Lavoinne A. Glutamine increases arginino-succinate synthetase mRNA levels in rat hepatocytes : the involvement of cell swelling. Eur J Biochem 1996 ; 236 : 56-9.
27. Hutson RG, Kilberg MS. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Biochem J 1994 ; 304 : 745-50.
28. Lavoinne A, Husson A, Quillard M, Chédeville A, Fairand A. Glutamine inhibits the lowering effect of glucose on the level of phosphoenolpyruvate carboxykinase mRNA in isolated rat hepatocytes. Eur J Biochem 1996 ; 242 : 537-43.
29. Husson A, Quillard M, Fairand A, Chédeville A, Lavoinne A. Hypoosmolarity and glutamine increased the β-actin gene transcription in isolated rat hepatocytes. FEBS Lett 1996 ; 394 : 353-5.
30. McLennan PA, Brown RA, Rennie MJ. A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. FEBS Lett 1987 ; 215 : 187-91.
31. Darmaun D. Intestin et métabolisme de la glutamine. Médecine/Sciences 1993 ; 9 : 884-90.