An interaction between penton base and αv integrins plays a minimal role in adenovirus-mediated gene transfer to hepatocytes in vitro and in vivo

Gene Therapy

Volumn 5, Issue 9, 1998, Pages 1259-1264

  Hautalal, T ^a,b   Grunst, T ^a   Fabrega, A ^c   Freimuth, P ^d   Welsh, M J ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF IOWA   (United States)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Adenovirus; Gene transfer; Hepatocytes; Integrin; Liver

Indexed keywords

INTEGRIN; VITRONECTIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURFACE; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; HELA CELL; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031666518     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300722     Document Type: Article

References (28)

1. Jaffe HA et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992; 1: 372-378.
2. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
3. Li Q et al. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther 1993; 4: 403-409.
4. Kozarsky KF et al. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 1994; 269: 13695-13702.
5. Vrancken Peeters M-JTFD et al. Adenovirus-mediated hepatic gene transfer in mice: comparison of intravascular and biliary administration. Hum Gene Ther 1996; 7: 1693-1699.
6. Morsy MA et al. Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes. J Clin Invest 1993; 92: 1580-1586.
7. Kozarsky K, Grossman M, Wilson JM. Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia. Som Cell Mol Genet 1993; 19: 449-458.
8. Castell JV et al. Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells. Gene Therapy 1997; 4: 455-464.
9. Louis N et al. Cell-binding domain of adenovirus serotype 2 fiber. J Virol 1994; 68: 4104-4106.
10. Bergelson JM et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997; 275: 1320-1323.
11. Mayr GA, Freimuth P. A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells. J Virol 1997; 71: 412-418.
12. Hong SS et al. Adenovirus type 5 fiber knob binds to MHC class I a2 domain at the surface of human epithelial and B lymphoblastoid cells. EABO J 1997; 16: 2294-2306.
13. Wickham TJ, Mathias P, Cheresh DA, Nernerow GR. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 1993; 73: 309-319.
14. Wickham TJ, Filardo EJ, Cheresh DA, Nemerow GR. Integrin αvβ5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol 1994; 127: 257-264.
15. Seth P. Adenovirus-dependent release of choline from plasma membrane vesicles at an acidic pH is mediated by the penton base protein. J Virol 1994; 68: 1204-1206.
16. Greber U F, Webster P, Weber J, Helenius A. The role of the adenovirus protease in virus entry into cells. EMBO J 1996; 15: 1766-1777.
17. Greber U F, Willetts M, Webster P, Helenius A. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 1993; 75: 477-486.
18. Greber UF et al. The role of the nuclear pore complex in adenovirus DNA entry. EMBO J 1997; 16: 5998-6007.
19. Bai M, Harfe B, Freimuth P. Mutations that alter an Arg-GlyAsp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. J Virol 1993; 67: 5198-5205.
20. Huang S et al. Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells. J Virol 1996; 70: 4502-4508.
21. Zabner J et al. Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection. J Clin Invest 1997; 100: 1144-1149.
22. 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J Virol 1995; 69: 5951-5958.
23. Grubb BR et al. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 1994; 371: 802-806.
24. Zabner J, Zeiher BG, Friedman E, Welsh MJ. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J Virol 1996; 70: 6994-7003.
25. Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells. J Cell Biol 1969; 43: 506-520.
26. Zabner J, Couture LA, Smith AE, Welsh MJ. Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro. Hum Gene Ther 1994; 5: 585-593.
27. Suzuki S et al. cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Proc Natl Acad Sci USA 1986; 83: 8614-8618.
28. Shuldiner AR, Tanner K, Moore CA, Roth J. RNA-template specific PCR: an improved method that dramatically reduces false positives in RT-PCR. Biotechniques 1991; 11: 760-763.