Determination of molsidomine and its active metabolite in human plasma using liquid chromatography with tandem mass spectrometric detection

Journal of Chromatography A

Volumn 819, Issue 1-2, 1998, Pages 113-123

  Streel, B ^a   Ceccato, A ^b   Peerboom, C ^a   Zimmer, C ^a   Sibenaler, R ^a   Maes, P ^a  

^a SMB Laboratories R and D   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Kinetic studies; Molsidomine; Morpholinosydnonimine; Pharmaceutical analysis; Sydnonimines

Indexed keywords

DRUG METABOLITE; LINSIDOMINE; MOLSIDOMINE;

ADULT; AREA UNDER THE CURVE; BLOOD ANALYSIS; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG DETERMINATION; EPIDURAL DRUG ADMINISTRATION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MASS SPECTROMETRY; MOLSIDOMINE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; VASODILATOR AGENTS;

EID: 0031665391     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(98)00323-9     Document Type: Conference Paper

References (23)

1. C. De Muynck, G.M.R. Vandenbossche, J.P. Remon, F. Colardyn, Am. J. Cardiol. 70 (1992) 836-837.
2. O. Spreux-Varoquaux, J. Doll, C. Dutot, N. Grandjean, P. Cordonnier, M. Pays, J. Andrieu, C. Advenier, Br. J. Clin. Pharmacol. 32 (1991) 399-401.
3. E. Grund, E.R. Müller-Ruchholtz, E.R. Lapp, H.-M. Lösch, W. Lochner, Arzneim.-Forsch. Drug Res. 28 (1978) 1624-1628.
4. J.-M. Detry, J. Melin, L. Brasseur, J. Cosyns, M. Rousseau, Am. J. Cardiol. 47 (1981) 109-115.
5. S. Guerchicoff, A. Vazquez, H. Kunik, S. Drajer, F. Diaz, Eur. J. Clin. Pharmacol. 13 (1978) 247-250.
6. C. Dutot, J. Moreau, P. Cordonnier, O. Spreux-Varoquaux, C. Klein, J. Ostrowski, C. Advenier, W. Gärtner, M. Pays, J. Chromatogr. 528 (1990) 435-446.
7. D. Dell, J. Chamberlain, J. Chromatogr. 146 (1978) 465-472.
8. A. Kömer, A. Peter, J. Chromatogr. A 689 (1995) 235-245.
9. C.M. Chavez, M.L. Constanzer, B.K. Matuszewski, J. Pharm. Biomed. Anal. 13 (1995) 1179-1184.
10. K. Matsuura, M. Kuwano, H. Takashina, J. Chromatogr. 621 (1993) 173-180.
11. M.L. Constanzer, C.M. Chavez, B.K. Matuszewski, J. Chromatogr. B 658 (1994) 281-287.
12. A. Xu, J. Havel, K. Linderholm, J. Hulse, J. Pharm. Biomed. Anal. 14 (1995) 33-42.
13. A. Xu, K. Linderholm, L. Peng, J. Hulse, J. Pharm. Biomed. Anal. 14 (1996) 1675-1680.
14. D.A. McLoughlin, T.V. Olah, J.D. Erllis, J.D. Gilbert, R.A. Halpin, J. Chromatogr. A 726 (1996) 115-124.
15. V.K. Boppana, C. Miller-Stein, W.H. Schaefer, J. Chromatogr. A 678 (1996) 227-236.
16. N.G. Knebel, M. Winkler, J. Chromatogr. B 702 (1997) 119-129.
17. T.H. Eichold, M. Quijano, W.L. Seibel, C.A. Cruze, R.L.M. Dobson, K.R. Wehmeyer, J. Chromatogr. B 698 (1997) 147-154.
18. A.P. Bruins, Th.R. Covey, J.D. Henion, Anal. Chem. 59 (1987) 2642-2646.
19. Ph. Hubert, P. Chiap, J. Crommen, J. Pharm. Biomed. Anal. 9 (1991) 877-882.
20. Ph. Hubert, P. Chiap, J. Crommen, J. Pharm. Biomed. Anal. 9 (1991) 883-887.
21. Y. Asahi, K. Shinozaki, M. Nagaoka, Chem. Pharm. Bull. 19 (1971) 1079-1088.
22. A.R. Buick, M.V. Doig, S.C. Jeal, G.S. Land, R.D. Mac Dowall, J. Pharm. Biomed. Anal. 8 (1990) 629.
23. J.C. Miller, J.N. Miller, in R.A. Chalmers, M. Masson (Editors), Statistics for Analytical Chemistry, Ellis Horwood, Chichester, 1984, p. 96.