메뉴 건너뛰기




Volumn 26, Issue 7, 1998, Pages 65-77

Pharmacokinetic studies on CI-981 (1) - Absorption, distribution and excretion in rats following single oral or intravenous administration

Author keywords

Absorption; Antihyperlipidemic agent; Atorvastatin; CI 981; Distribution; Excretion; HMG CoA reductase inhibitor; Rat

Indexed keywords

ATORVASTATIN;

EID: 0031664847     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (4)

References (11)
  • 1
    • 0026567257 scopus 로고
    • Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981; Comparison with selected HMG-CoA reductase inhibitors
    • Bocan TMA et al: Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981; Comparison with selected HMG-CoA reductase inhibitors. Biochim Biophys Acta 1123: 133-144, 1992
    • (1992) Biochim Biophys Acta , vol.1123 , pp. 133-144
    • Bocan, T.M.A.1
  • 2
    • 0029113047 scopus 로고
    • Lipid-lowering activity of atorvastatin and lovastatin in rodent species; Triglyceride-lowering in rats correlates with efficacy in LDL animal models
    • Krause BR, Newton RS: Lipid-lowering activity of atorvastatin and lovastatin in rodent species; Triglyceride-lowering in rats correlates with efficacy in LDL animal models. Atherosclerosis 117: 237-244, 1995
    • (1995) Atherosclerosis , vol.117 , pp. 237-244
    • Krause, B.R.1    Newton, R.S.2
  • 3
    • 9044230921 scopus 로고    scopus 로고
    • Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia
    • Bakker-Arkema RG et al: Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia. JAMA 275: 128-133, 1996
    • (1996) JAMA , vol.275 , pp. 128-133
    • Bakker-Arkema, R.G.1
  • 4
    • 8244259180 scopus 로고    scopus 로고
    • Efficacy of atorvastatin in primary hypercholesterolemia
    • Japan Cholesterol Lowering Atorvastatin Study (J-CLAS) Group: Efficacy of atorvastatin in primary hypercholesterolemia. Am J Cardiol 79: 1248-1252, 1997
    • (1997) Am J Cardiol , vol.79 , pp. 1248-1252
  • 5
    • 0002410513 scopus 로고
    • In vitro and in vivo metabolism of atorvastatin (CI-981)
    • Raleigh, NC, USA, Abstract No. 93
    • Michniewicz BM et al: In vitro and in vivo metabolism of atorvastatin (CI-981). Sixth North American ISSX Meeting, Raleigh, NC, USA, Abstract No. 93, 1994
    • (1994) Sixth North American ISSX Meeting
    • Michniewicz, B.M.1
  • 6
    • 7344226168 scopus 로고    scopus 로고
    • Japanese source
  • 8
    • 0027819738 scopus 로고
    • Tissue selectivity of hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors
    • Sirtori CR: Tissue selectivity of hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharmac Ther 60: 431-459, 1993
    • (1993) Pharmac Ther , vol.60 , pp. 431-459
    • Sirtori, C.R.1
  • 9
    • 0026065171 scopus 로고
    • Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase
    • Roth BD et al: Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase. J Med Chem 34: 463-466, 1991
    • (1991) J Med Chem , vol.34 , pp. 463-466
    • Roth, B.D.1
  • 10
    • 0345451764 scopus 로고    scopus 로고
    • Responses to the inhibition of HMG-CoA reductase; a comparison of simvastatin and atorvastatin
    • Bergstrom JD et al: Responses to the inhibition of HMG-CoA reductase; A comparison of simvastatin and atorvastatin. Atherosclerosis 134: 121, 1997
    • (1997) Atherosclerosis , vol.134 , pp. 121
    • Bergstrom, J.D.1
  • 11
    • 0005548466 scopus 로고    scopus 로고
    • Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin
    • Naoumova RP et al: Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin. Atherosclerosis 134: 130, 1997
    • (1997) Atherosclerosis , vol.134 , pp. 130
    • Naoumova, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.