The amino acid transport system y+L/4F2hc is a heteromultimeric complex

FASEB Journal

Volumn 12, Issue 13, 1998, Pages 1319-1329

  Estévez, Raúl ^a   Camps, Marta ^a   Rojas, Ana María ^c   Testar, Xavier ^a   Devés, Rosa ^c   Hediger, Matthias A ^b   Zorzano, Antonio ^a   Palacín, Manuel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Erythrocyte; Homologous protein; Mutagenesis; Oocyte; Y+L transport activity

Indexed keywords

AMINO ACID; ARGININE; COMPLEMENTARY RNA; CYSTEINE; LEUCINE; MEMBRANE PROTEIN; MERCAPTOETHANOL; MERCURY;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

EID: 0031664699     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.13.1319     Document Type: Article

References (47)

1. +-independent neutral amino acid transporter from rat kidney. Proc. Natl. Acad. Sci. USA 89, 1-5
2. Bertrán, J., Werner, A., Moore, M. L., Stange, G.,Markovich, D., Biber, J., Testar, X., Zorzano, A., Palacín, M., and Murer, H. (1992) Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids. Proc. Natl. Acad. Sci. USA 89, 5601-5605
3. Wells, R. G., and Hediger, M. A. (1992) Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases. Proc. Natl. Acad. Sci. USA 89, 5596-5600
4. +-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. Proc. Natl. Acad. Sci. USA 89, 5606-5610
5. Wells, R. G., Lee, W., Kanai, Y., Leiden, J. M., and Hediger, M. A. (1992) The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. J. Biol. Chem. 267, 15285-15288
6. Furriols, M., Chillarón, J., Mora, C., Castelló, A., Bertran, J., Camps, M., Testar, X., Vilaró, S., Zorzano, A., and Palacín, M. (1993) rBAT, related to L-cystine transport is localized to the microvilli of proximal straight tubules and its expression is regulated in kidney by development. J. Biol. Chem. 268, 27060-27068
7. Pickel, V. M., Nirenberg, M. J., Chan, J., Mosckovitz, R., Udenfriend, S., and Tate, S. S. (1993) Ultrastructural localization of a neutral and basic amino acid transporter in rat kidney and intestine. Proc. Natl. Acad. Sci. USA 90, 7779-7783
8. o,+-like amino acid transport system in a 'renal proximal tubular' cell line (OK cells). J. Biol. Chem. 271, 10569-10576
9. Calonge, M. J., Gasparini, P., Chillarón, J., Chillón, M., Gallucci, M., Rousaud, F., Zelante, L., Testar, X., Dallapiccola, B., Di Silverio, F., Barceló, P., Estivill, X., Zorzano, A., Nunes, V., and Palacin, M. (1994) Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine. Nature Genet. 6, 420-425
10. Chillarón, J., Estévez, R., Samarzija, I., Waldegger, S., Testar, X., Lang, F., Zorzano, A., Busch, A., and Palacín, M. (1997) An intracellular trafficking defect in type I cystinuria rBAT mutants M467T and M467K. J. Biol. Chem. 272, 9543-9549
11. Calonge, M. J., Volpini, V., Bisceglia, L., Rousaud, F., DeSantis, L., Brescia, E., Zelante, L., Testar, X., Zorzano, A., Estivill, X., Gasparini, P., Nunes, V., and Palacín, M. (1995) Genetic heterogeneity in cystinuria: the rBAT gene is linked to type I but not to type III cystinuria. Proc. Natl. Acad. Sci. USA 92, 9667-9671
12. Bisceglia, L., Calonge, M. J., Totaro, A., Feliubadalo, L., Melchionda, S., Garcia, J., Testar, X., Gallucci, M., Ponzone, A., Zelante, L., Zorzano, A., Estivill, X., Gasparini, P., Nunes, V., and Palacín, M. (1997) Localization, by linkage analysis, of the cystinuria type III gene to chromosome 19q13.1. Am. J. Hum. Genet. 60, 611-616
13. Wartenfeld, R., Golomb, E., Katz, G., Bale, S. J., Goldman, B., Pras, M., Kastner, D. L., and Pras, E. (1997) Molecular analysis of cystinuria in Libyan Jews: exclusion of the SLC3A1 gene and mapping of a new locus on 19q. Am. J. Hum. Genet. 60, 617-624
14. Segal, S., and Thier, S. O. (1995) Cystinuria. In The Metabolic and Molecular Bases of Inherited Diseases (Scriver, C. H., Beaudet, A. L., Sly y, W. S., and Valle, D., eds) pp. 3581-3601, McGraw-Hill, New York
15. -L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids. J. Biol. Chem. 271, 17761-17770
16. +L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen. Biochemistry 34, 8744-8751
17. +-independent isoleucine transport activity from rat brain in Xenopus laevis oocytes. Biochim. Biophys. Acta 1192, 95-100
18. Bröer, S., Bröer, A., and Hamprecht, B. (1995) The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes. Biochem. J. 312, 863-870
19. Bröer, S., Bröer, A., and Hamprecht, B. (1997) Expression of the surface antigen 4F2hc affects system-L-like neutral-amino-acid-transport activity in mammalian cells. Biochem. J. 324, 535-541
20. Quackenbush, E., Clabby, M., Gottesdiener, K. M., Barbosa, J., Jones, N. H., Strominger, J. L., Speck, S., and Leiden, J. M. (1987) Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc. Natl. Acad. Sci, USA 84, 6526-6530
21. 2 terminus. J. Biol. Chem. 262, 9574-9580
22. Mosckovitz, R., Udenfriend, S., Felix, A., Heimer, E., and Tate, S. S. (1994) Membrane topology of the rat kidney neutral and basic amino acid transporter. FASEB J. 8, 1069-1074
23. Haynes, B. F., Hemler, M. E., Mann, D. L., Eisenbarth, G. S., Shelhamer, J. H., Mostowski, H. S., Thomas, C. A., Strominger, J. L., and Fauci A. S. (1981) Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J. Immunol. 126, 1409-1414
24. Hemler, M. E., and Strominger, J. L. (1982) Characterization of the antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. J. Immunol. 129, 623-628
25. Wang, Y., and Tate, S. S. (1995) Oligomeric structure of a renal cystine transporter: implications in cystinuria. FEBS Lett. 368, 389-392
26. 0,--like amino acid-transport system in the renal reabsorption of cystine and dibasic amino acids. Biochem. Soc. Trans. 24, 856-863
27. Albritton, L. M., Tseng, L., Scadden, D., and Cunningham, J. M. (1989) A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell 57, 659-666
28. + type cationic amino acid transport in Xenopus oocytes and show different tissue expression patterns. Transgene 1, 91-101
29. +L) in human erythocytes that recognizes lysine and leucine with high affinity. J. Physiol. (London) 454, 491-501
30. Deves, R., Angelo, S., and Chavez, P. (1993) N-ethylmaleimide discriminates between two lysine transport systems in human erythrocytes. J. Physiol. (London) 468, 753-766
31. Mora, S. (1996) GLUT-4 glucose transporter trafficking in Xenopus laevis oocytes and in rat skeletal muscle cells. Ph.D. thesis. Department of Biochemistry and Molecular Biology, Universitat de Barcelona, Spain
32. Wang, K.-W., and Goldstein, S. A. N. (1995) Subunit composition of minK potassium channels. Neuron 14, 1303-1309
33. Tate, S. S. (1996) Evidence suggesting that the minimal functional unit of a renal cystine transporter is a heterodimer and its implications in cystinuria. Amino Acids 11, 209-224
34. +-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes. J. Biol. Chem. 271, 16758-16763
35. Peter, G. J., Davidson, I. G., Ahmed, A., McIlroy, L., Forrester, A. R., and Taylor, P. M. (1996) Multiple components of arginine and phenylalanine transport induced in neutral and basic amino acid transporter-cRNA-injected Xenopus oocytes. Biochem. J. 318, 915-922
36. Ahmed, A., Yao, P. C., Brant, A. M., Peter, G.J., and Harper, A. A. (1997) Electrogenic L-histidine transport in neutral and basic amino acid transporter (NBAT)-expressing Xenopus laevis oocytes. Evidence for two functionally distinct transport mechanisms induced by NBAT expression. J. Biol. Chem. 272, 125-130
37. Bröer, S., Broër, A., and Hamprecht, B. (1997) Expression of the surface antigen 4F2hc (CD 98) affects system L-like neutral amino acid transport in mammalian cells. Amino Acids 13, 45
38. +-ATPase in Xenopus oocytes. Am. J. Physiol. 257, C851-C858
39. Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M., and Romey, G. (1996) KvLQT1 and ISK (minK) proteins associate to form the IKS cardiac potassium current. Nature (London) 384, 78-80
40. Sanguinetti, M. C., Curran, M. E., Zou, A., Shen, J., Spector, P. S., Atkinson, D. L., and Keating, M. T. (1996) Coassembly of K(V)LQT1 and minK (ISK) proteins to form cardiac IKS potassium channel. Nature (London) 384, 80-83
41. - channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron 16, 423-429
42. Tai, K.-K., Wang, K.-W., and Goldstein, A. N. (1997) MinK potassium channels are heteromultimeric complexes. J. Biol. Chem. 272, 1654-1658
43. Chen, J.-G., Liu-Chen, S., and Rudnick, G. (1997) External cysteine residues in the serotonin transporter. Biochemistry 36, 1479-1486
44. Parmacek, M. S., Karpinski, B. A., Gottesdiener, K. M., Thompson, C. B., and Leiden, J. M. (1989) Structure, expression and regulation of the murine 4F2 heavy chain. Nucleic Acids Res. 17, 1915-1931
45. Bertrán, J., Werner, A., Chillarón, J., Nunes, V., Biber, J.,Testar, X., Zorzano, A., Estivill, X., Murer, H., and Palacín, M. (1993) Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes. J. Biol. Chem. 268, 14842-14849
46. Lee, W.-S., Wells, R. G., Sabbag, R. V., Mohandas, T. K., and Hediger, M. A. (1993) Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport. J. Clin. Invest. 91, 1959-1963
47. Waldegger, S., Schmidt, F., Herzer, T., Gulbins, E., Schuster, A., Biber, J., Markuvich, D., Murer, H., Busch, A. E., and Lang, F. (1995) Heavy metal mediated inhibition of rBAT-induced amino acid transport. Kidney Int. 47, 1677-1681