Use of a prenylation inhibitor as a novel antiviral agent

Journal of Virology

Volumn 72, Issue 11, 1998, Pages 9303-9306

  Glenn, Jeffrey S ^a   Marsters Jr , James C ^b   Greenberg, Harry B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZODIAZEPINE; DIMETHYL SULFOXIDE; DIMETHYLALLYLTRANSFERASE; DITHIOTHREITOL; DRUG CARRIER; ENZYME INHIBITOR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS DELTA ANTIGEN;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; HEPATITIS DELTA VIRUS; LIVER DISEASE; MOUSE; NONHUMAN; ONCOGENE H RAS; PRENYLATION; PRIORITY JOURNAL; RABBIT; RETICULOCYTE LYSATE; VIRION; VIRUS ASSEMBLY; VIRUS PARTICLE;

EID: 0031664153     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.11.9303-9306.1998     Document Type: Article

References (34)

1. Armstrong, S. A., V. C. Hannah, J. L. Goldstein, and M. S. Brown. 1995. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranyl to Rho B. J. Biol. Chem. 270:7864-7868.
2. Bonino, F., B. Hoyer, J. W.-K. Shih, M. Rizzetto, R. H. Purcell, and J. L. Gerin. 1984. Delta hepatitis agent: structural and antigenic properties of the delta-associated particle. Infect. Immun. 43:1000-1005.
3. Bruss, V., and D. Ganem. 1991. Mutational analysis of hepatitis B surface antigen particle assembly and secretion. J. Virol. 65:3813-3820.
4. Casey, J. L. 1996. Hepatitis delta virus. Genetics and pathogenesis. Clin. Lab. Med. 16:451-464.
5. Chang, F.-L., P.-J. Chen, S.-J. Tu, C.-J. Wang, and D.-S. Chen. 1991. The large form of hepatitis δ antigen is crucial for assembly of hepatitis δ virus. Proc. Natl. Acad. Sci. USA 88:8490-8494.
6. Chao M., S.-Y. Hsieh, and J. Taylor. 1990. Role of two forms of hepatitis delta virus antigen: evidence for a mechanism of self-limiting genome replication. J. Virol. 64:5066-5069.
7. Chow, M., C. J. Der, and J. E. Buss. 1992. Structure and biological effects of lipid modifications on proteins. Curr. Opin. Cell Biol. 4:629-636.
8. Cova, L., I. Fourel, L. Vitvitski, V. Lambert, S. Chassot, et al. 1993. Animal models for the understanding and control of HBV and HDV infections. J. Hepatol. 17(Suppl. 3):S143-S148.
9. Dalton, M. B., K. S. Fantle, H. A. Bechtold, L. DeMaio, R. M. Evans, et al. 1995. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. Cancer Res. 55:3295-3304.
10. Glenn, J. S. 1995. Prenylation and virion morphogenesis, p. 83-93. In G. Dinter-Gottlieb (ed.), The unique hepatitis delta virus. R. G. Landes Company, Austin, Tex.
11. Glenn, J. S., J. A. Watson, C. M. Havel, and J. M. White. 1992. Identification of a prenylation site in delta virus large antigen. Science 256:1331-1333.
12. Glenn, J. S., and J. M. White. 1991. trans-Dominant inhibition of human hepatitis delta virus genome replication. J. Virol. 65:2357-2361.
13. Glomset, J. A., M. H. Gelb, and C. C. Farnsworth. 1990. Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochem. Sci. 15: 139-142.
14. Hoofnagle, J. H. 1989. Type D (delta) hepatitis. JAMA 261:1321-1325.
15. James, G. L., J. L. Goldstein, M. S. Brown, T. E. Rawson, T. C. Somers, et al. 1993. Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science 260:1937-1942.
16. Lai, M. M. C. 1995. The molecular biology of hepatitis delta virus. Annu. Rev. Biochem. 64:259-286.
17. Laub, O., L. B. Rall, M. Truett, Y. Shaul, D. N. Standring, P. Valenzuela, and W. J. Rutter. 1983. Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J. Virol. 48: 271-280.
18. Lazinski, D. W., and J. M. Taylor. 1994. Recent developments in hepatitis delta virus research. Adv. Virus Res. 43:187-231.
19. Lee, C.-Z., P.-J. Chen, M. M. C. Lai, and D.-S. Chen. 1994. Isoprenylation of large hepatitis delta antigen is necessary but not sufficient for hepatitis delta virus assembly. Virology 199:169-175.
20. Liu, C. C., D. Yansura, and A. Levinson. 1982. Direct expression of hepatitis B surface antigen in monkey cells from an SV40 vector. DNA 1:213-221.
21. Marshall, C. J. 1993. Protein prenylation: a mediator of protein-protein interaction. Science 259:1865-1866.
22. Marsters, J. C., Jr., R. S. McDowell, M. E. Reynolds D. A. Oare, T. C. Somers, et al. 1994. Benzodiazepine peptidomimetic inhibitors of farnesyltransferase. Bioorg. Med. Chem. 2:949-957.
23. Otto, J. C., and P. J. Casey. 1996. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. J. Biol. Chem. 271:4569-4572.
24. Rizzetto, M. 1983. The delta agent. Hepatology 3:729-737.
25. Ryu, W.-S., M. Bayer, and J. Taylor. 1992. Assembly of hepatitis delta virus particles. J. Virol. 66:2310-2315.
26. Schafer, W. R., and J. Rine. 1992. Protein prenylation: genes, enzymes, targets, and functions. Annu. Rev. Genet. 30:209-237.
27. Simon, K., V. R. Lingappa, and D. Ganem. 1988. Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J. Cell Biol. 107:2163-2168.
28. Sureau, C., and R. Lanford. 1993. Analysis of hepatitis B virus envelope proteins in assembly and infectivity of human hepatitis delta virus, p. 45-51. In S. J. Hadziyannis, J. M. Taylor, and F. Bonino (ed.), Hepatitis delta virus: molecular biology, pathogenesis, and clinical aspects. Wiley-Liss, Inc., New York, N.Y.
29. Taylor, J. M. 1992. The structure and replication of hepatitis delta virus. Annu. Rev. Microbiol. 46:253-276.
30. Trueblood, C. E., Y. Ohya, and J. Rine. 1993. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:4260-4275.
31. Wang, C.-J., P.-J. Chen, J.-C. Wu, D. Patel, and D.-S. Chen. 1991. Small-form hepatitis B surface antigen is sufficient to help in the assembly of hepatitis delta virus-like particles. J. Virol. 65:6630-6636.
32. Wang, K.-S., Q.-L. Choo, A. J. Weiner, J.-H. Ou, R. C. Najarian, et al. 1986. Structure, sequence and expression of the hepatitis delta viral genome. Nature 323:508-514.
33. Wu, J.-C., P.-J. Chen, M. Y. P. Kuo, S.-D. Lee, D.-S. Chen, and L.-P. Ting. 1991. Production of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line. J. Virol. 65:1099-1104.
34. Zhang, F. L., and P. J. Casey. 1996. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241-269.