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Volumn 209, Issue 1, 1998, Pages 259-267

Intra- and extracellular fluorouracil uptake: Assessment with contrast- enhanced metabolic F-19 MR imaging

Author keywords

Fluorouracil; Gadolinium; Liver neoplasms; Magnetic resonance (MR), contrast agents; Magnetic resonance (MR), nuclei other than H; Neoplasms, experimental; Neoplasms, MR

Indexed keywords

ALPHA FLUORO BETA ALANINE; CONTRAST MEDIUM; FLUORINE; FLUOROURACIL; GADOLINIUM PENTETATE MEGLUMINE; GADOXETIC ACID; UNCLASSIFIED DRUG;

EID: 0031661321     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiology.209.1.9769841     Document Type: Article
Times cited : (21)

References (38)
  • 1
    • 33745464490 scopus 로고
    • Fluorinated pyrimidines: A new class of tumor-inhibitory compounds
    • Heidelberger CH, Chaudhuri NK, Danneberg P, et al. Fluorinated pyrimidines: a new class of tumor-inhibitory compounds. Nature 1957; 179:663-666.
    • (1957) Nature , vol.179 , pp. 663-666
    • Heidelberger, C.H.1    Chaudhuri, N.K.2    Danneberg, P.3
  • 2
    • 0028088241 scopus 로고
    • Current approaches to metastatic colorectal cancer
    • Kemeny N. Current approaches to metastatic colorectal cancer. Semin Oncol 1994; 21:67-75.
    • (1994) Semin Oncol , vol.21 , pp. 67-75
    • Kemeny, N.1
  • 3
    • 0027980010 scopus 로고
    • Preclinical and clinical aspects of biomodulation of 5-fluorouracil
    • Sotos GA, Grogan L, Allegra CJ. Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat Rev 1994; 20: 11-49.
    • (1994) Cancer Treat Rev , vol.20 , pp. 11-49
    • Sotos, G.A.1    Grogan, L.2    Allegra, C.J.3
  • 4
    • 0019753942 scopus 로고
    • On the rational development of a new drug: The example of the fluorinated pyrimidines
    • Heidelberger C. On the rational development of a new drug: the example of the fluorinated pyrimidines. Cancer Treat Rep 1981; 65:3-9.
    • (1981) Cancer Treat Rep , vol.65 , pp. 3-9
    • Heidelberger, C.1
  • 5
    • 0019537132 scopus 로고
    • The pharmacology of the fluoropyrimidines
    • Myers CE. The pharmacology of the fluoropyrimidines. Pharmacol Rev 1981; 33:1-15.
    • (1981) Pharmacol Rev , vol.33 , pp. 1-15
    • Myers, C.E.1
  • 7
    • 0021233990 scopus 로고
    • New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR
    • Malet-Martino MC, Martino R, Lopez A, et al. New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR. Cancer Chemother Pharmacol 1984; 13:31-35.
    • (1984) Cancer Chemother Pharmacol , vol.13 , pp. 31-35
    • Malet-Martino, M.C.1    Martino, R.2    Lopez, A.3
  • 8
    • 0023931286 scopus 로고
    • 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pre-treatment
    • 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pre-treatment. Cancer Res 1988; 48:1680-1688.
    • (1988) Cancer Res , vol.48 , pp. 1680-1688
    • Hull, W.E.1    Port, R.E.2    Herrmann, R.3    Britsch, B.4    Kunz, W.5
  • 9
    • 0024757133 scopus 로고
    • 19F MRS studies of fluoropyrimidine chemotherapy: A review
    • 19F MRS studies of fluoropyrimidine chemotherapy: a review. NMR Biomed 1989; 2:133-141.
    • (1989) NMR Biomed , vol.2 , pp. 133-141
    • McSheehy, P.M.J.1    Griffiths, J.R.2
  • 10
    • 0025921621 scopus 로고
    • 19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver
    • 19F magnetic resonance spectroscopy studies of the metabolism of 5-fluorouracil in murine RIF-1 tumors and liver. Cancer Res 1991; 51:1384-1390.
    • (1991) Cancer Res , vol.51 , pp. 1384-1390
    • Sijens, P.E.1    Huang, Y.2    Baldwin, N.J.3    Ng, T.C.4
  • 11
    • 0026360179 scopus 로고
    • 19F nuclear magnetic resonance spectroscopy
    • 19F nuclear magnetic resonance spectroscopy. Cancer Res 1991; 51:5806-5812.
    • (1991) Cancer Res , vol.51 , pp. 5806-5812
    • El-Tahtawy, A.1    Wolf, W.2
  • 13
    • 0025887689 scopus 로고
    • Multinuclear MR investigations of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy
    • Sijens PE, Baldwin NJ, Ng TC. Multinuclear MR investigations of the metabolic response of the murine RIF-1 tumor to 5-fluorouracil chemotherapy. Magn Reson Med 1991; 19:373-385.
    • (1991) Magn Reson Med , vol.19 , pp. 373-385
    • Sijens, P.E.1    Baldwin, N.J.2    Ng, T.C.3
  • 14
    • 0023212874 scopus 로고
    • Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy
    • Wolf W, Albright MJ, Silver MS, Weber H, Reichardt U, Sauer R. Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy. Magn Reson Imaging 1987; 5:165-169.
    • (1987) Magn Reson Imaging , vol.5 , pp. 165-169
    • Wolf, W.1    Albright, M.J.2    Silver, M.S.3    Weber, H.4    Reichardt, U.5    Sauer, R.6
  • 15
    • 0025096726 scopus 로고
    • 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits
    • 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc Natl Acad Sci USA 1990; 87:492-496.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 492-496
    • Wolf, W.1    Presant, C.A.2    Servis, K.L.3
  • 17
    • 0025058615 scopus 로고
    • Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy
    • Semmler W, Bachert-Baumann P, Gückel F, et al. Real-time follow-up of 5-fluorouracil metabolism in the liver of tumor patients by means of F-19 MR spectroscopy. Radiology 1990; 174:141-145.
    • (1990) Radiology , vol.174 , pp. 141-145
    • Semmler, W.1    Bachert-Baumann, P.2    Gückel, F.3
  • 18
    • 0025043987 scopus 로고
    • 19F nuclear magnetic resonance spectroscopy pharmacokinetics
    • 19F nuclear magnetic resonance spectroscopy pharmacokinetics. J Clin Oncol 1990; 8:1868-1873.
    • (1990) J Clin Oncol , vol.8 , pp. 1868-1873
    • Presant, C.A.1    Wolf, W.2    Albright, M.J.3
  • 19
    • 0025906814 scopus 로고
    • Kinetic modeling of in vivo nuclear magnetic resonance spectroscopy data: 5-fluorouracil in liver and liver tumors
    • Port RE, Bachert P, Semmler W. Kinetic modeling of in vivo nuclear magnetic resonance spectroscopy data: 5-fluorouracil in liver and liver tumors. Clin Pharmacol Ther 1991; 49:497-505.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 497-505
    • Port, R.E.1    Bachert, P.2    Semmler, W.3
  • 20
    • 0028281081 scopus 로고
    • 19F NMR study during 5-FU chemotherapy in patients with metastases of colorectal adenocarcinoma
    • 19F NMR study during 5-FU chemotherapy in patients with metastases of colorectal adenocarcinoma. Magn Reson Imaging 1994; 12:497-511.
    • (1994) Magn Reson Imaging , vol.12 , pp. 497-511
    • Schlemmer, H.P.1    Bachert, P.2    Semmler, W.3
  • 22
    • 0030763054 scopus 로고    scopus 로고
    • 18F]fluorouracil tissue concentrations measured with positron emission tomography in patients with liver metastases from colorectal adenocarcinoma
    • 18F]fluorouracil tissue concentrations measured with positron emission tomography in patients with liver metastases from colorectal adenocarcinoma. Cancer Res 1997; 54:3415-3423.
    • (1997) Cancer Res , vol.54 , pp. 3415-3423
    • Kissel, J.1    Brix, G.2    Bellemann, M.E.3
  • 25
    • 0025409428 scopus 로고
    • Magnetic resonance contrast media: Principles and progress
    • Lauffer RB. Magnetic resonance contrast media: principles and progress. Magn Reson Med 1990; 6:65-84.
    • (1990) Magn Reson Med , vol.6 , pp. 65-84
    • Lauffer, R.B.1
  • 30
    • 0013828726 scopus 로고
    • Studies on the development, biochemistry and biology of experimental hepatomas
    • Morris HP. Studies on the development, biochemistry and biology of experimental hepatomas. Adv Cancer Res 1965; 9:227-302.
    • (1965) Adv Cancer Res , vol.9 , pp. 227-302
    • Morris, H.P.1
  • 31
    • 0028935442 scopus 로고
    • A perspective on k-space
    • Mezrich R. A perspective on k-space. Radiology 1995; 195:297-315.
    • (1995) Radiology , vol.195 , pp. 297-315
    • Mezrich, R.1
  • 32
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: A review
    • Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res 1987; 47:3039-3051.
    • (1987) Cancer Res , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 33
    • 0025733874 scopus 로고
    • Haemodynamic and transport barriers to the treatment of solid tumors
    • Jain RK. Haemodynamic and transport barriers to the treatment of solid tumors. Int J Radiat Biol 1991; 60:85-100.
    • (1991) Int J Radiat Biol , vol.60 , pp. 85-100
    • Jain, R.K.1
  • 34
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain RK. Barriers to drug delivery in solid tumors. Sci Am 1994; 271:58-65.
    • (1994) Sci Am , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 35
    • 0027253923 scopus 로고
    • Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal cancer
    • Dimitrakopoulou A, Strauss LG, Clorius JH, et al. Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal cancer. J Nucl Med 1993; 34:1075-1081.
    • (1993) J Nucl Med , vol.34 , pp. 1075-1081
    • Dimitrakopoulou, A.1    Strauss, L.G.2    Clorius, J.H.3
  • 37
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
    • Hertel LW, Boder GB, Kroin JS, et al. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res 1990; 50:4417-4422.
    • (1990) Cancer Res , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 38
    • 85038554777 scopus 로고
    • Fluorine-19 NMR mapping of the novel anticancer drug gemcitabine (2′,2′-difluoro-2′-deoxycytidine) in experimental tumor systems
    • Berkeley, Calif: International Society for Magnetic Resonance in Medicine
    • Bellemann ME, Brix G, Haberkorn U, et al. Fluorine-19 NMR mapping of the novel anticancer drug gemcitabine (2′,2′-difluoro-2′-deoxycytidine) in experimental tumor systems (abstr). In: Proceedings of the Third Meeting of the International Society for Magnetic Resonance in Medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, 1995; 1685.
    • (1995) Proceedings of the Third Meeting of the International Society for Magnetic Resonance in Medicine , pp. 1685
    • Bellemann, M.E.1    Brix, G.2    Haberkorn, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.