Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Anti-Cancer Drug Design

Volumn 13, Issue 7, 1998, Pages 825-835

  Dorr, Robert T ^a   Bellamy, William ^a   Liddil, James D ^a   Baker, Amanda ^a   Bair, Kenneth W ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b Sandoz Pharma Ltd   (Switzerland)

Author keywords

DNA intercalation; Mechanism of action; Topoisomerase II

Indexed keywords

2 [(3 FLUORANTHENYL)METHYLAMINO] 2 METHYL 1,3 PROPANEDIOL; 2 [(7 METHYLBENZO[C]CARBAZOL 5 YL)METHYLAMINO] 2 METHYL 1,3 PROPANEDIOL; ANTINEOPLASTIC AGENT; CELL PROTEIN; CRISNATOL; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REGRESSION ANALYSIS;

ANTINEOPLASTIC AGENTS; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HUMANS; INTERCALATING AGENTS; PROPYLENE GLYCOLS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0031661177     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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