Soluble CD21 (sCD21) forms biologically active complexes with CD23: SCD21 is present in normal plasma as a complex with trimeric CD23 and inhibits soluble CD23-induced IgE synthesis by B cells

International Immunology

Volumn 10, Issue 10, 1998, Pages 1459-1466

  Frémeaux Bacchi, Véronique ^a   Fischer, Elizabeth ^a   Lecoanet Henchoz, Sybille ^b   Mani, Jean Claude ^c   Bonnefoy, Jean Yves ^b   Kazatchkine, Michel D ^a  

^a HÔPITAL BROUSSAIS   (France)

^b GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

^c CNRS   (France)

Author keywords

CD21; CD23; IgE; Soluble receptors

Indexed keywords

CD23 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN E; INTERLEUKIN 4;

AFFINITY CHROMATOGRAPHY; ARTICLE; B LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOGLOBULIN PRODUCTION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

B-LYMPHOCYTES; COMPLEMENT C3; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; LIGANDS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, COMPLEMENT 3D; RECEPTORS, IGE; SOLUBILITY;

EID: 0031660615     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.10.1459     Document Type: Article

References (36)

1. r membrane protein as the C3d receptor (CR2) of human B lymphocytes. Proc. Natl Acad. Sci. USA 81:881.
2. Fingeroth, J. D., Weis, J. J., Tedder, T. F., Strominger, J. L., Biro, P. A. and Fearon, D. T. 1984. Epstein-Barr virus of virus of human B lymphocytes is the C3d receptor CR2. Proc. Natl Acad. Sci. USA 81:4510.
3. Ahearn, J. M. and Fearon, D. T. 1989. Structure and function of the complement receptors CR1 (CD35) and CR2 (CD21). Adv. Immunol. 46:183.
4. Aubry, J. P., Pochon, S., Graber, P., Jansen, K. U. and Bonnefoy, J. Y. 1992. CD21 is a ligand for CD23 and regulates IgE production. Nature 358:505.
5. Weis, J. J., Toothaker, L. E., Smith, J. A., Weis, J. H. and Fearon, D. T. 1988. Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and the relatedness to other members of the family of C3/C4 binding proteins. J. Exp. Med. 167:1047.
6. Nemerow, G. R., Mold, C., Schwend, V. K., Tollefson, V. and Cooper, N. R. 1987. Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d. J. Virol. 61:1416.
7. Aubry, J. P., Pochon, S., Gauchat, J. F., Nueda-Marin, A., Holers, M., Graber, P., Siegfried, C. and Bonnefoy, J. Y. 1994. CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21. J. Immunol. 152:5806.
8. Tedder, T. F., Clement, L. T. and Cooper, M. D. 1984. Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with HB5 monoclonal antibodies J. Immunol. 146:865.
9. Reynes, M., Aubert, J., Cohen, J. H. M., Audouin, J., Tricottet, V., Diebold, J. and Kazatchkine, M. D. 1985. Human follicular dendritic cells express CR1, CR2 and CR3 complement receptor antigens. J. Immunol. 135:2687.
10. Fischer, E., Delibrias, C. and Kazatchkine, M. D. 1991. Expression of CR2 (the C3dg/EBV receptor CD21) on normal human peripheral blood human T lymphocytes. J. Immunol. 146:865.
11. Delibrias, C. C., Mouhoub, A., Fischer, E. and Kazatchkine, M. D. 1994. CR1(CD35) and CR2 (CD21) complement C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus Eur. J. Immunol. 24:2784.
12. Tsoukas, C. D. and Lambris, J. D. 1988. Expression of CR2/ EBV receptor on human thymocytes detected by monoclonal antibodies. Eur. J. Immunol. 18:1299.
13. Bonnefoy, J. Y., Henchoz, S., Hardie, D., Holder, M. J. and Gordon, J. 1993. A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis Eur. J. Immunol. 23:969.
14. Flores-Romo, L., Shields, J., Humbert, Y., Graber, P., Aubry, J. P., Gauchat, J. F., Ayala, G., Allet, B., Chavez, M., Bazin, H., Capron, M. and Bonnefoy, J. Y. 1993. Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science 261:1038
15. + T cell clones. Eur. J. Immunol. 24:2982.
16. Carter, R. H., Spycher, M. O., Ng, Y. C., Hoffman, R. and Fearon, D. T. 1988. Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes. J. Immunol. 141:457.
17. Myones, B. L. and Ross, G. D. 1987. Identification of a spontaneously shed fragment of B cell complement receptor type two (CR2) containing the C3d binding site. Complement 4:87.
18. Ling, N., Hansel, T., Richardson, P. and Brown, B. 1991. Cellular origins of serum complement receptor type 2 in normal individuals and in hypogammaglobulinemia. Clin. Exp. Immunol. 84:16.
19. Huemer, H. P., Larcher, C., Prodinger, W. M., Petzer, A. L., Mitterer, M. and Falser, N. 1993. Determination of soluble CD21 as a parameter of B cell activation. Clin. Exp. Immunol. 93:195.
20. Frémeaux-Bacchi, V., Bernard, I., Maillet, F., Mani, J. C., Fontaine, M., Bonnefoy, J. Y., Kazatchkine, M. D. and Fischer, E. 1996. Human lymphocytes shed a soluble form of CD21(the C3dg/ Epstein-Barr virus receptor, CR2) that binds iC3b and CD23. Eur. J. Immunol. 26:1497.
21. Sutton, B. J. and Gould, H. J. 1993. The human IgE network. Nature 366:421.
22. Lowell, C. A., Klickstein, L. B., Carter, R. H., Mitchell, J. A., Fearon, D. T. and Ahearn, J. M. 1989. Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. J. Exp. Med. 170:1931
23. Cook, J., Fischer, E., Boucheix, C., Mirsrahi, M., Jouvin, M. H., Weiss, L., Jack, R. and Kazatchkine, M. D. 1985. Mouse monoclonal antibodies to the human C3b receptor. Mol. Immunol 22:531.
24. Ross, G. D., Lambris, J. D., Cain, J. A. and Newman, S. L. 1982. Generation of three different fragments of bound C3 with purified factor I or serum. J. Immunol. 129:2051.
25. Pêne, J., Rousset, F., Brière, F., Chrétien, I., Wideman, J., Bonnefoy, J. Y. and De Vries, J. E. 1988. Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen. Eur. J. Immunol. 18:929.
26. Micklem, K., Sim, E. and Sim, R. B. 1985. The generation of active fragments of complement receptor type 2 by trypsin digestion. FEBS Lett. 189:195.
27. Seya, T., Hara, T., Iwata, K., Kuriyama, S., Hasegawa, T., Nagase, Y., Miyagawa, S., Matsumoto, M., Hatanaka, J. P. and Nagasawa, S. 1995. Purification and functional properties of soluble forms of membrane cofactor protein (CD46) of complement: identification of forms increased in cancer patients' sera. Int. Immunol. 7:727.
28. Galon, J., Gauchat, J. F., Mazieres, N., Spagnoli, R., Storkus, W., Lötze, M., Bonnefoy, J. Y., Fridman, W. H. and Sautes, C. 1996. Soluble Fcγ receptor type III (FcγR II, CD16) triggers cell activation through interaction with complement receptors. J. Immunol. 157:1184.
29. Trotter, J. L., Damico, C. A., Trotter, A. L., Collins, K. G. and Cross, A. H. 1995. Interleukin-2 binding proteins in sera from normal subjects and multiple sclerosis patients. Neurology 45:1971.
30. Hong, K., Takata, Y., Sayama, K., Kozono, H., Nakano, Y., Kinoshita, T. and Inoue, K. 1984. Inhibition of immune precipitation by complement. J. Immunol. 133:1464
31. Saint-Remy, J. M., Magnusson, C. G. and Masson, P. L. 1983. Activation of the classical pathway of human complement by a human monoclonal IgE, IgE(DES). J. Immunol. 130:1341.
32. Beavil, A. J., Edmeades, R. L., Gould, H. J. and Sutton, B. J. 1992. α-Helical coiled-coil stalks in the low-affinity receptor for IgE (CD23/FcεRII) and related C-type lectins. Proc. Natl Acad. Sci. USA 89:753.
33. Beavil, R. L., Graber, P., Aubonney, N., Bonnefoy, J. Y. and Gould, H. J. 1995. CD23/FcεRII and its soluble fragments can form oligomers on the cell surface and in solution. Immunology 84:202.
34. Bansal, A. S., Ollier, W., Marsh, M. N., Pumphrey, R. S. H. and Wilson, P. B. 1993. Variations in serum sCD23 in conditions with either enhanced humoral or cell-mediated immunity. Immunology 79:285.
35. Bohnsack, J. F. and Cooper, N. R. 1988. CR2 ligands modulate human B cell activation. J. Immunol. 141:2569.
36. Henchoz, S., Gauchat, J. F., Aubry, J. P., Graber, P., Pochon, S. and Bonnefoy, J. Y. 1994. Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts. Immunology 81:285.