Protective effect of Withania somnifera root extract on electrographic activity in a lithium-pilocarpine model of status epilepticus

Phytotherapy Research

Volumn 12, Issue 6, 1998, Pages 451-453

  Kulkarni, S K ^a   George, B ^a   Mathur, R ^b  

^a PANJAB UNIVERSITY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Lithium; Pilocarpine; Status epilepticus; Withania somnifera

Indexed keywords

WITHANIA SOMNIFERA EXTRACT;

ANIMAL MODEL; ANTICONVULSANT THERAPY; ARTICLE; DRUG EFFECT; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; NONHUMAN; PLANT ROOT; RAT;

ANIMALIA; WITHANIA SOMNIFERA;

EID: 0031659574     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199809)12:6<451::AID-PTR328>3.0.CO;2-C     Document Type: Article

References (10)

1. George, B., and Kulkarni, S. K. (1996). Protective effect of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus. Meth. Find. Exp. Clin. Pharmacol. 18, 335-340.
2. George, B., Mathur, R., and Kulkarni, S. K. (1997). Protective effect of acute clozapine on pilocarpine models of status epilepticus in rats: a behavioural, electroencephalographic and neuropathological study. Asia Pacific J. Pharmacol. (in press).
3. Honchar, M. P., Olney, J. W., and Sherman, W. R. (1983). Systemic cholinergic agents induce seizures and brain damage in lithium treated rats. Science 220, 323-325.
4. Kulkarni, S. K., and George, B. (1995). Amgdaloid kindling in rats: Protective effect of Withania somnifera (Aswagandha) root extract. Indian Drugs 32, 37-49.
5. Kulkarni, S. K., and George, B. (1996). Anticonvulsant action of Withania somnifera (Aswagandha) root extract against pentylenetetrazol-induced kindling in mice. Phytother. Res. 10, 447-449.
6. Kulkarni, S. K., Sharma, A., Verma, A., and Ticku, M. K. (1993). GABA receptor mediated anticonvulsant action of Withania somnifera root extract. Indian Drugs 30, 305-312.
7. Kulkarni, S. K., and Verma, A. V. (1993). Aswagandha and Brahmi: Nootropic and de-addiction profile of psychotropic indigenous plants. Drugs of Today 29, 257-263.
8. A receptor complex. Indian J. Med. Res. 94, 312-315.
9. Paxinos, G., and Watson, C. (1982). The Rat Brain in Stereotaxic Coordinates, 1st edn, Academic Press, Sydney.
10. Wasterlain, C. G., Baxter, C. F., and Baldwin, R. A. (1993). GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus. Neurochem. Res. 18, 527-532.