Mobilization of lead by calcium versenate and dimercaptosuccinate in the rat

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 9, 1998, Pages 686-692

  Tandon, Sushil K ^a   Singh, Surendra ^a   Prasad, Satgur ^a   Mathur, Neeraj ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Calcium versenate; Dimercaptosuccinic acid; Essential elements; Lead; Rat

Indexed keywords

AMINOLEVULINIC ACID; EDETATE CALCIUM DISODIUM; SUCCIMER; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; KIDNEY; LEAD POISONING; LIVER; MALE; NEUROTOXICOLOGY; NONHUMAN; RAT;

EID: 0031658857     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02277.x     Document Type: Article

References (23)

1. Jones MM. New developments in therapeutic chelating agents as antidotes for metal poisoning. Crit. Rev. Toxicol. 1991; 21: 209-33.
2. Goyer RA, Cherian MG, Jones MM, Reigart JR. Role of chelating agents for prevention, intervention and treatment of exposures to toxic metals. Environ. Health Perspec. 1995; 103: 1048-52.
3. Tandon SK. Detrimental heavy metal detoxication. In: Berthon G (ed.). Handbook on Metal-Ligand Interactions in Biological Fluids. Bioinorganic Medecine. Marcel Dekker Inc., New York, 1995; 1297-305.
4. Cory-Slechta DA. Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy. J. Pharmacol. Exp. Ther. 1988; 246: 84-91.
5. Chisolm Jr JJ. BAL, BDTA, DMSA and DMPS in the treatment of lead poisoning in children. J. Toxicol. Clin. Toxicol. 1992; 30: 493-504.
6. Tandon SK, Singh S, Jain VK. Efficacy of combined chelation in lead intoxication. Chem. Res. Toxicol. 1994; 7: 583-9.
7. Flora SJS, Bhattacharya R, Vijayraghavan R. Combined therapeutic potential of meso-2,3-dimercapto-succinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats. Fund. Appl. Toxicol. 1995; 25: 233-40.
8. Berlin A, Schaller KH. European standardized method for determination of delta-aminolevulinic acid dehydratase activity in blood. Z. Klin. Chem. Klin. Biochem. 1974; 12: 389-90.
9. Davis JR, Abrahams RH, Fishbein WI, Fabrega EA. Urinary delta-aminolevulinic acid (ALA) levels in lead poisoning II. Correlation with clinical findings in 250 children with suspected lead ingestion. Arch. Environ. Health 1968; 17: 164-71.
10. Clegg JW, King EJ. Estimation of hemoglobin by the alkaline hematin method. BMJ 1942; 2: 329-33.
11. Yeager DW, Cholak J, Henderson EW. Determination of lead in biological and related material by atomic absorption spectrophotometry. Environ. Sci. Technol. 1971; 5: 1020-2.
12. Parker MN, Humoller FL, Mahler DJ. Determination of copper and zinc in biological materials. Clin. Chem. 1967; 13: 40-8.
13. Zar JH. Biostatistical Analysis, 2nd edn. Prentice Hall, Englewood Cliffs; 1984.
14. Moel DI, Kumar K. Reversible nephrotoxic reactions to a combined 2,3-demercapto-1-propanol and calcium disodium ethylenediaminetetracetic acid regimen in asymptomatic children with elevated blood lead levels. Pediatrics 1982; 70: 259-62.
15. Thomas DJ, Chisolm JJ, Lead, zinc and copper decorporation during calcium disodium ethylenediamine tetraacetate treatment of lead-poisoned children. J. Pharmacol. Exp. Ther. 1986; 239: 829-35.
16. Cory-Slechta DA, Weiss B, Cox C. Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy. J. Pharmacol. Exp. Ther. 1987; 243: 804-13.
17. Sillen LG, Martell AE. Stability Constants of Metal-Ion Complexes. Special Publication no. 17. The Chemical Society, London, 1964.
18. Harris WR, Chen Y, Stenback J, Shah B. Stability constants for dimercaptosuccinic acid with bismuth (III), zinc (II) and lead (II). J. Co-ord. Chem. 1991; 23: 173-86.
19. Andersen O. Chelation of cadmium. Environ. Health Perspect. 1984; 54: 249-66.
20. Ehadi M. Biochemical characterization of metallothionein-like protein in rat brain. Biol. Trace Element. Res. 1986; 11: 101-6.
21. Ebadi M, Harma Y. Zinc binding proteins in the brain: In: Schwarcz R, Ben-Ari Y (eds). Excitary Amino acids and Epilepsy. Plenum Press, New York, 1986; 557-70.
22. Edabi M. Metallothioneins and other zinc-binding proteins in brain. Methods Enzymol. 1991; 205: 363-87.
23. Angel CR. Childhood lead poisoning and its treatment. Annu. Rev. Pharmacol. Toxicol. 1993; 33: 409-34.