Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 9, 1998, Pages 2431-2433

  Van Etten, Els W M ^a   Snijders, Susan V ^a   Van Vianen, Wim ^a   Bakker Woudenberg, Irma A J M ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; MACROGOL; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DRUG EFFICACY; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LEUKOPENIA; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031658260     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.9.2431     Document Type: Article

References (7)

1. Bakker-Woudenberg, I. A. J. M., A. F. Lokerse, M. T. ten Kate, J. W. Mouton, M. C. Woodle, and G. Storm. 1993. Liposomes with prolonged blood circulation and selective localization in Klebsiella pneumoniae-infected lung tissue. J. Infect. Dis. 168:164-171.
2. Bakker-Woudenberg, I. A. J. M., M. T. ten Kate, L. E. T. Stearne-Cullen, and M. C. Woodle. 1495. Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiella pneumoniae infected lung tissue. J. Infect. Dis. 171:938-947.
3. Leenders, A. C. A. P., and S. De Marie. 1996. The use of lipid formulations of amphotericin B for systemic fungal infections. Leukemia 10:1570-1575.
4. Legrand, P., M. Chéron, L. Leroy, and J. Bolard. 1997. Release of amphotericin B from delivery systems and its action against fungal and mammalian cells. J. Drug Targeting 4:311-319.
5. van Etten, E. W. M., C. van den Heuvel-De Groot, and I. A. J. M. Bakker-Woudenberg. 1993. Efficacies of amphotericin B-desoxycholate (Fungizone), liposomal amphotericin B (AmBisome) and fluconazole in the treatment of systemic candidosis in immunocompetent and leucopenic mice. J. Antimicrob. Chemother. 32:723-739.
6. van Etten, E. W. M., W. van Vianen, R. H. G. Tijhuis, G. Storm, and I. A. J. M. Bakker-Woudenberg. 1995. Sterically stabilized amphotericin B-liposomes: toxicity and biodistribution in mice. J. Control. Release 37:123-129.
7. van Etten, E. W. M., M. T. ten Kate, L. E. T. Stearne, and I. A. J. M. Bakker-Woudenberg. 1995. Amphotericin B liposomes with prolonged circulation in blood: in vitro antifungal activity, toxicity, and efficacy in systemic candidiasis in leukopenic mice. Antimicrob. Agents Chemother. 39: 1954-1958.