DNA modifications by the mutagen glyoxal: Adduction to G and C, deamination of C and GC and GA cross-linking

Carcinogenesis

Volumn 19, Issue 8, 1998, Pages 1459-1465

  Kasai, Hiroshi ^a   Iwamoto Tanaka, Naoko ^a   Fukada, Shoko ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCYTIDINE; DEOXYURIDINE; DOUBLE STRANDED DNA; GLYOXAL; MUTAGENIC AGENT; SINGLE STRANDED DNA;

ARTICLE; CROSS LINKING; DEAMINATION; DNA ADDUCT; DNA DEGRADATION; DNA MODIFICATION; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ASPERGILLUS NUCLEASE S1; CYTOSINE; DEAMINATION; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYURIDINE; DNA ADDUCTS; GLYOXAL; GUANINE; THYMIDINE;

EID: 0031657569     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.8.1459     Document Type: Article

References (18)

1. Nagao,M., Fujita,Y., Wakabayashi,K., Nukaya,H., Kosuge,T. and Sugimura,T. (1986) Mutagens in coffee and other beverages. Environ. Health Perspect., 67, 89-91.
2. Frankel,E.N. (1982) Volitile lipid oxidation products. Prog. Lipid Res., 22, 1-33.
3. Ueno,H., Nakamuro,K., Sayato,Y. and Okada,S. (1991) DNA lesion in rat hepatocytes induced by in vitro and in vivo exposure to glyoxal. Mutat. Res., 260, 115-119.
4. Furihata,C., Hotta,A., Sato,Y. and Matsushima,T. (1989) Alkaline elution of DNA from stomach pyloric mucosa of rats treated with glyoxal. Mutat. Res., 213, 227-231.
5. Furihata,C., Yoshida,S. and Matsushima,T. (1985) Potential initiating and promoting activities of diacetyl and glyoxal in rat stomach mucosa. Jpn. J. Cancer Res. (Gann), 76, 809-814.
6. Takahashi,M., Okamiya,H., Furukawa,F., Toyoda,K., Sato,H., Imaida,K. and Hayashi,Y. (1989) Effects of glyoxal and methylglyoxal administration on gastric carcinogenesis in Wistar rats after initiation with N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis, 10, 1925-1927.
7. Murata-Kamiya,N., Kamiya,H., Iwamoto,N. and Kasai,H. (1995) Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals. Carcinogenesis, 16, 2251-2253.
8. Murata-Kamiya,N., Kaji,H. and Kasai,H. (1997) Types of mutations induced by glyoxal, a major oxidative DNA damage product, in Salmonella typhimurium. Mutat. Res., 377, 13-16.
9. Murata-Kamiya,N., Kamiya,H., Kaji,H. and Kasai,H. (1997) Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110. Mutat. Res., 377, 255-262.
10. Murata-Kamiya,N., Kamiya,H., Kaji,H. and Kasai,H. (1997) Glyoxal, a major product of DNA oxidation, induces mutation at G:C sites on a shuttle vector plasmid replicated in mammalian cells. Nucleic Acids Res., 25, 1897-1902.
11. Staehelin,M. (1959) Inactivation of virus nucleic acid with glyoxal derivatives. Biochim. Biophys. Acta, 31, 448-454.
12. Shapiro,R. and Hachmann,J. (1966) The reaction of guanine derivatives with 1,2-dicarbonyl compounds. Biochemistry, 5, 2799-2807.
13. Chaw,Y.F., Crane,L.E., Lange,P. and Shapiro,R. (1980) Isolation and identification of cross-links from formaldehyde-treated nucleic acids. Biochemistry, 19, 5525-5531.
14. Nakaya,K., Takenaka,O., Horinishi,H. and Shibata,K. (1968) Reaction of glyoxal with nucleic acids, nucleotides and their component bases. Biochim. Biophys. Acta, 161, 23-31.
15. Lindahl,T. and Nyberg,B. (1974) Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry, 13, 3405-3410.
16. Hollstein,M., Sidransky,D., Vogelstein,B. and Harris,C.C. (1991) p53 mutations in human cancers. Science, 253, 49-53.
17. Lindahl,T. (1993) Instability and decay of the primary structure of DNA. Nature, 362, 709-715.
18. Kuchenmeister,F., Engelhardt,G., Schmezer,P. and Bartsch,H. (1997) Genotoxic aldehydes produce specific comet assay images. Mutat. Res., 379 (suppl.), S133.