Potential cardiovascular applications of glutamate, aspartate, and other amino acids

Clinical Cardiology

Volumn 21, Issue 9, 1998, Pages 620-624

  Arsenian, Michael ^a,b  

^a Division of Cardiology   (United States)

^b Cape Ann Medical Center   (United States)

Author keywords

Aspartate; Cardioplegia; Glutamate

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; INSULIN; ORNITHINE; POTASSIUM; TIOPRONIN; UBIDECARENONE;

ANIMAL MODEL; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; HEART INFARCTION; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART PROTECTION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIC HEART DISEASE; NONHUMAN; REPERFUSION INJURY; REVIEW;

EID: 0031657086     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.4960210904     Document Type: Review

References (44)

1. Opie LH: Metabolism of the heart in health and disease. Am Heart J 1968;76:685-698
2. Pozefsky T, Felig P, Tobin JD, Soeldner JS, Cahill GF: Amino acid balance across tissues of the forearm in postabsorptive man. J Clin Invest 1969;48:2273-2282
3. Svedjeholm R, Ekroth R, Joachimsson P, Ronquist G, Svensson S, Tyden H: Myocardial uptake of amino acids and other substrates in relation to myocardial oxygen consumption four hours after cardiac operations. J Thorac Cardiovasc Surg 1991;101:688-694
4. Taegtmeyer H, Peterson MH, Ragavan VV, Ferguson AG, Lesch M: De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium. J Biol Chem 1977;252:5010-5018
5. Gailis L, Benmouyal E: Endogenous alanine, glutamate, aspartate, and glutamine in perfused guinea-pig heart. Effect of substrates and cardioactive agents. Can J Biochem 1973;51:11-20
6. Veitch K, Hombroeckx A, Caucheteux D, Pouleur H, Hue L: Global ischaemia induces a biphasic response of the mitochondrial respiratory chain. Biochem J 1992;281:709-715
7. Berkowitz S, Penile P, Lesch M: Anaerobic amino acid metabolism as a potential energy source in mammalian hearts. Clin Res 1978;26:291A
8. Mudge GH, Mills RM, Taegtmeyer H, Gorlin R, Lesch M: Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J Clin Sci Invest 1976;58:1185-1192
9. Thomassen AR, Nielsen TT, Bagger JP, Henningsen P: Myocardial exchange of glutamate, alanine, and citrate in controls and patients with coronary artery disease. Clin Sci 1983;64:33-40
10. 13N)-glutamate in the normal human heart and in patients with coronary artery disease. Eur J Nucl Med 1982;7:211-215
11. Taegtmeyer H: Metabolic responses to cardiac hypoxia: Increased production of succinate by rabbit papillary muscles. Circ Res 1978; 43:808-815
12. Sanborn T, Gavin W, Berkowitz S, Perille T, Lesch M: Augmented conversion of aspartate and glutamate to succinate during anoxia in rabbit heart. Am J Physiol 1979;237:H535-H541
13. Owen TG, Hochachka PW: Purification and properties of dolphin muscle aspartate and alanine transaminases and their possible role in the energy metabolism of diving mammals. Biochem J 1974;143: 541-553
14. Hochachka PW, Storey KB: Metabolic consequences of diving in animals and man. Science 1975;187:613-621
15. Hochachka PW, Owen TG, Allen JF, Whitlow EC: Multiple end products of anaerobiosis in diving vertebrates. Comp Biochem Physiol 1975;50B:17-22
16. Kirkendol PL, Pearson JE, Robie NW: The cardiac and vascular effects of sodium glutamate. Clin Exp Pharm Physiol 1980;7: 617-625
17. Thomassen A, Nielsen TT, Bagger JP, Henningsen P: Effects of intravenous glutamate on substrate availability and utilization across the human heart and leg. Metabolism 1991;40:378-384
18. Davis EJ, Bremmer J: Studies with isolated surviving rat hearts. Interdependence of free amino acids and citric acid-cycle intermediates. Eur J Biochem 1973;38:86-97
19. Pisarenko OI, Lepilin MG, Ivanov VE: Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure. Clin Sci 1986;70:7-12
20. Watanabe T, Yamakazi A, Aoyama S: Significance of myocardial ammonia metabolism in the failing heart. Israel J Med Sci 1969;5: 496-500
21. Burns AH, Reddy WJ: Amino acid stimulation of oxygen and substrate utilization by cardiac myocytes. Am J Physiol 1978;235: E461-E466
22. Rau EE, Shine KI, Gervais A, Douglas AM, Amos EC: Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion. Am J Physiol 1979;236:H873-H879
23. Cairns C, Ferroggiaro A, Walther J, Harken A, Banerjee A: Post-ischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury. Circulation 1996;94:I-414
24. Taegtmeyer H, Ferguson AG, Lesch M: Protein degradation and amino acid metabolism in autolyzing rabbit myocardium. Exp Mol Pathol 1977;26:52-62
25. Penney DG, Cascarano J: Anaerobic rat heart: Effects of glucose and tricarboxylic acid cycle metabolites on metabolism and physiological performance. Biochem J 1970;118:221-227
26. Pisarenko OI, Solomatina ES, Studneva JM, Ivanov VE, Kapelko VI, Smirnov VN: Protective effect of glutamic acid on cardiac function and metabolism during cardioplegia and reperfusion. Basic Res Cardiol 1983;78:534-543
27. Singh J, Garg KN, Garg D, Chugh K, Lal H: Effect of aspartate and glutamate on experimental myocardial infarction in rats. Ind J Exp Biol 1989;27:621-624
28. Bittl JA, Shine KI: Protection of ischemic rabbit myocardium by glutamic acid. Am J Physiol 1983;245:H406-H412
29. Julia P, Young HH, Buckberg GD, Kofsky ER, Bugyi HI: Studies of myocardial protection in the immature heart. J Thorac Cardiovasc Surg 1991;101:23-32
30. Lazar HL, Buckberg GD, Manganaro AJ, Becker H, Maloney JV: Reversal of ischemic damage with amino acid substrate enhancement during reperfusion. Surgery 1980;88:702-709
31. Lazar HL, Buckberg GD, Manganaro AM, Becker H: Myocardial energy replenishment and reversal of ischemic damage by substrate enhancement of secondary blood cardioplegia with amino acids during reperfusion. J Thorac Cardiovasc Surg 1980;80:350-359
32. Rosenkranz E, Okamoto F, Buckberg G, Vinten-Johansen J, Robertson J, Bugyi H: Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts. J Thorac Cardiovasc Surg 1984;88:402-410
33. Rosenkranz ER, Okamoto F, Buckberg GD, Robertson JM, Vinten-Johansen J, Bugyi HI: Safety of prolonged aortic clamping with blood cardioplegia. III. Aspartate enrichment of glutamate-blood cardioplegia in energy-depleted hearts after ischemic and reperfusion injury. J Thorac Cardiovasc Surg 1986;91:428-435
34. Engleman RM: Rosou JA, Flack JE, Iyengar J, Kimura Y, Das DK: Reduction of infarct size by systemic amino acid supplementation during reperfusion. J Thorac Cardiovasc Surg 1991;101:855-859
35. Beyersdorf F, Acar C, Buckberg GDI: Studies on prolonged acute regional ischemia. V. Metabolic support of remote myocardium during left ventricular power failure. J Thorac Cardiovasc Surg 1989;98:567-579
36. Gharagozloo F, Melendez F, Hein R: The effect of amino acid L-glutamate on the extended preservation ex vivo of the heart for transplantation. Circulation 1987;6(suppl V):65-70
37. Kjellman U, Bjork K, Ekroth R: Alpha-ketoglutarate for myocardial protection in heart surgery. Lancet 1995;345:552-553
38. Robertson J, Vinten-Johansen J, Buckberg G, Rosenkranz E, Moloney J: Safety of prolonged aortic clamping with blood cardioplegia. I. Glutamate enrichment in normal hearts. J Thorac Cardiovasc Surg 1984;88:395-401
39. Thomassen A, Botker HE, Nielsen TT, Thygesen K, Henningsen P: Effects of glutamate on exercise tolerance and circulation substrate levels in stable angina pectoris. Am J Cardiol 1990;65:173-178
40. Thomassen A, Nielsen TT, Bagger JP, Pedersen AK, Henningsen P: Antiischemic and metabolic effects of glutamate during pacing in patients with stable angina pectoris secondary to either coronary artery disease or syndrome X. Am J Cardiol 1991;68:291-295
41. Svedjeholm R, Huljebrant I, Hakanson E, Vanhanen I: Glutamate and high-dose glucose-insulin-potassium in the treatment of severe cardiac failure after cardiac operations. Ann Thorac Surg 1995; 59:523-530
42. Beyersdorf F, Kirsh M, Buckberg GD, Allen BS: Warm glutamate/ aspartate-enriched blood cardioplegic solution for perioperative sudden death. J Thorac Cardiovasc Surg 1992;104:1141-1147
43. Choi DW: Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity. Brain Res 1987;403:333-336
44. Kochhar A, Zivin JA, Lyden PD, Mazzarella V: Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia. Arch Neurol 1988;45:148-153