A transgene-centered approach to the biosafety of transgenic phosphinothricin-tolerant plants

Molecular Breeding

Volumn 4, Issue 4, 1998, Pages 335-341

  Metz, Peter L J ^a   Stiekema, Willem J ^a   Nap, Jan Peter ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Ecology; Genetic modification; Herbicides; Risk assessment; Toxicology

Indexed keywords

BIOSAFETY; HERBICIDE TOLERANCE; PHOSPHINOTHRICIN; TRANSGENE; TRANSGENIC PLANT;

BIOHAZARDS; CROPS; ECOLOGY; GENES; HERBICIDES; PLANTS (BOTANY); WEED CONTROL;

'CURRENT; BAR GENES; GENETIC MODIFICATIONS; HERBICIDE TOLERANCE; PAT GENE; PHOSPHINOTHRICIN; RISKS ASSESSMENTS; TOXICOLOGY; TRANSGENE; TRANSGENICS;

RISK ASSESSMENT;

EID: 0031656162     PISSN: 13803743     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009695124173     Document Type: Article

References (46)

1. Arias DM, Rieseberg LH: Gene flow between cultivated and wild sunflowers. Theor Appl Genet 89: 655-660 (1994).
2. Arriola PE: Risks of escape and spread of engineered genes from transgenic crops to wild relatives. AgBiotechnol News Info 9: 157-160 (1997).
3. Arriola PE, Ellstrand NC: Crop-to-weed gene flow in the genus Sorghum (Poaceae); spontaneous interspecific hybridization between johnsongrass, Sorghum halepense, and crop sorghum, S. bicolor. Am J Bot 83: 1153-1160 (1996).
4. Bayer E, Gugel KH, Hägele K, Hagenmaier H, Jessipow S, König WA, Zähner H: Phosphinothricin und Phosphinothricyl-Alanyl-Alanin. Helv Chim Acta 55: 224-239 (1972).
5. Berkowitz DB: The food safety of transgenic animals. Bio/technology 8: 819-825 (1990).
6. De Block M, Botterman J, Vandewiele M, Dockx J, Thoen C, Gosselé V, Rao Movva N, Thompson C, Van Montagu M, Leemans J: Engineering herbicide resistance in plants by expression of a detoxifying enzyme. EMBO J 6: 2513-2518 (1987).
7. Botterman J, Gosselé V, Thoen C, Lauwereys M: Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins. Gene 102: 33-37 (1991).
8. Botterman J, Leemans J: Engineering herbicide resistance in plants. Trends Genet 4: 219-221 (1988).
9. Crawley MJ: Arm-chair risk assessment, Bio/technology 11: 1496 (1993).
10. Crawley MJ: Reply on comment Miller et al. Bio/technology 12: 217 (1994).
11. Crawley MJ, Hails RS, Rees M, Kohn D, Buxton J: Ecology of transgenic oilseed rape in natural habitats. Nature 363: 620-623 (1993).
12. Devine MD, Duke SO, Fedtke C: Physiology of Herbicide Action. PTR Prentice Hall, Englewood Cliffs, NJ (1993).
13. Dröge W, Broer I, Pühler A: Transgenic plants containing the phosphinothricin-N-acetyltransferase gene metabolize the herbicide L-phosphinothricin (glufosinate) differently from untransformed plants. Planta 187: 142-151 (1992).
14. Dorn E, Görlitz G, Heusel R, Stumpf K: Verhalten von Glufosinat-ammonium in der Umwelt: Abbau im und Einfluss auf das Ökosystem. Z Pflanzenkrankh und Pflanzenschutz 13: 459-468 (1992).
15. Dröge-Laser W, Siemeling U, Pühler A, Broer I: The metabolites of the herbicide-phosphinothricin (glufosinate). Plant Physiol 105: 159-166 (1994).
16. Ebert E, Leist KH, Mayer D: Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol 28: 339-349 (1990).
17. Food and Drug Administration/Environmental Protection Agency/United States Department of Agriculture: Proceedings 'Conference on scientific issues related to potential allergenicity in transgenic food crops', Annapolis, MD, 18-19 April (1994).
18. Fredshavn JR, Poulsen GS, Huybrechts I, Rüdelsheim P: Competitiveness of transgenic oilseed rape. Transgen Res 4: 142-148 (1995).
19. Greef W de, Delon R, de Block M, Leemans J, Botterman J: Evaluation of herbicide resistance in transgenic crops under field conditions. Bio/technology 7: 61-64 (1989).
20. Hoechst: Finale Produktinformatie. September 1984 (1984).
21. Jones DD, Maryanski JH: Safety considerations in the evaluation of transgenic plants for human food. In: Levin MA and Strauss HS (eds) Risk Assessment in Genetic Engineering, pp. 64-82. McGraw-Hill, New York (1991).
22. Kareiva P: Transgenic plants on trial. Nature 363: 580-581 (1993).
23. Keeler KH: Can genetically engineered crops become weeds? Bio/technology 7: 1134-1139 (1989).
24. Kishore GM, Shah DM: Amino acid biosynthesis inhibitors as herbicides. Annu Rev Biochem 57: 627-663 (1988).
25. de Laat AAM, van Dun CMP: Inbouw van herbicide-resistentiegenen in gewassen; overwegingen van een verdelingsbedrijf. Gewasbescherming 25: 179-183 (1994).
26. Lea PJ, Joy KW, Ramos JL, Guerrero MG: The action of the 2-amino-4-(methylphosphinyl)-butanoic acid (phosphinothricin) and its 2-oxo-derivative on the metabolism of cyanobacteria and higher plants. Phytochemistry 23: 1-6 (1984).
27. Lindhoud WM: HOE 39866 (Glufosinate-ammonium): state of development and prospects for the Netherlands. Med Fac Landbouwwet Rijksuniv Gent 49: 1085-1090 (1984).
28. Metz PLJ, Nap JP: A transgene-centered approach to the biosafety of transgenic crops: overview of selection and reporter genes. Acta Bot Neerl 46: 25-50 (1997).
29. Miller H, Beachy R, Huttner SL: Risk assessment redux. Bio/technology 12: 216-217 (1994).
30. Miller H, Huttner SL, Beachy R: Risk assessment experiments for 'genetically modified' plants. Bio/technology 11: 1323-1324 (1993).
31. Müllner H, Eckes P, Donn G: Engineering crop resistance to the naturally occurring glutamine synthetase inhibitor phosphinothricin. In: Duke SO, Menn JJ, Plimmer JR (eds) Pest Control with Enhanced Environmental Safety, pp. 38-47. ACS Symposium Series 524. American Chemical Society, Washington, DC (1993).
32. Murakami T, Anzai H, Imai S, Satoh A, Nagaoka K, Thompson CJ: The bialaphos biosynthetic genes of Streptomyces hygroscopicus: molecular cloning and characterization of the gene cluster. Mol Gen Genet 205: 42-50 (1986).
33. Nap JP, Bijvoet J, Stiekema WJ: Biosafety of kanamycin-resistant transgenic plants. Transgen Res 1: 39-249 (1992).
34. Rijn JP van, Straalen NM van, Willems J: Handboek bestrijdingsmiddelen: gebruik en milieueffecten. VU Uitgeverij, Amsterdam, Netherlands (1995).
35. Schlüter K, Fütterer J, Potrykus I: 'Horizontal' gene transfer from a transgenic potato line to a bacterial pathogen (Erwinia chrysanthemi) occurs -if at all- at an extremely low frequency. Bio/technology 13: 1094-1098 (1995).
36. Strauch E, Wohlleben W, Pühler A: Cloning of a phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Streptomyces lividans and Escherichia coli. Gene 63: 65-74 (1988).
37. Tachibana K, Watanabe T, Sekizuwa Y, Takematsu T: Accumulation of ammonia in plants treated with bialaphos. J Pestic Sci 11: 33-37 (1986).
38. Tebbe CC, Reber HH: Utilization of the herbicide phosphinothricin as a nitrogen source by soil bacteria. Appl Microbiol Biotechnol 29: 103-105 (1988).
39. Thompson C, Movva N, Tizard R, Crameri R, Davies J, Lauwereys M, Botterman J: Characterization of the herbicide resistance gene 'bar' from Streptomyces hygroscopicus. EMBO J 6: 2519-2523 (1987).
40. Tiedje JM, Colwell RK, Grossman YL, Hodson RE, Lenski RE, Mack RN, Regal PJ: The planned introduction of genetically engineered organisms: ecological considerations and recommendations. Ecology 70: 298-315 (1989).
41. Trinks K: Studies on the phosphinothricin acetyltransferase gene and protein. Mitt Biol Bundesanst 309: 49 (1995).
42. Walter C, Broer I, Hillemann D, Pühler A: High frequency, heat treatment-induced inactivation of the phosphinothricin resistance gene in transgenic single cell suspension cultures of Medicago sativa. Mol Gen Genet 235: 189-196 (1992).
43. Williamson M: Environmental risks from the release of genetically modified organisms (GMOs): the need for molecular ecology. Mol Ecol 1: 3-8 (1992).
44. Wohlleben W, Arnold W, Broer I, Hillemann D, Strauch E, Pühler A: Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Nicotiana tabacum. Gene 70: 25-37 (1988).
45. WSSA (Weed Science Society of America): Herbicide Handbook, 7th ed., pp. 147-149 (1994).
46. Yoneyama K, Anzai H: Transgenic plants resistant to diseases by the detoxification of toxins. In: Biotechnology in Plant Disease Control, pp. 115-137. Wiley-Liss, New York (1993).