Time course of the tilorone-induced lysosomal accumulation of sulphated glycosaminoglycans in cultured fibroblasts

Experimental and Toxicologic Pathology

Volumn 50, Issue 4-6, 1998, Pages 411-415

  Bispinck, Freia ^a   Fischer, Jens ^b   Lüllmann Rauch, Renate ^c   Ziecenhagen, Manfred W ^a  

^a Department of Pharmacology ^*  (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Dicationic amphiphilic drugs; Drugs, dicationic amphiphilic; Glycosaminoglycans, sulphated; Lysosomal GAG storage; Lysosomes; Tilorone

Indexed keywords

AMPHOPHILE; DERMATAN SULFATE; GLYCOSAMINOGLYCAN POLYSULFATE; IMMUNOMODULATING AGENT; SODIUM SULFATE; TILORONE;

ANIMAL CELL; ARTICLE; CATTLE; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; FIBROBLAST CULTURE; LYSOSOME; NONHUMAN; RADIOCHEMISTRY;

EID: 0031656130     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(98)80027-4     Document Type: Article

References (26)

1. CANTZ M, KRESSE H, BARTON R\V, NEUFELD EF: Corrective factors for inborn errors of mucopolysaccharide metabolism. Meth Enzymol 1972; 28: 884-897.
2. CREEK KE, SLY WS: The role of the phosphomannosyl receptor in the transport of acid hydrolases to lysosomes. In: DINGLE JT, DEAN RT, SLY W (eds): Lysosomes in Biology and Pathology. Elsevier, Amsterdam, 1984; Vol. 7, pp 63-82.
3. DE DUVE C, DE BARSY T, POOLE B, et al.: Lysosomotropic agents. Biochem Pharmacol 1974; 23: 2495-2531.
4. FANGER B O: Adaptation of the Bradford protein assay to membrane-bound proteins by solubilizing in glucopyranoside detergents. Anal Biochem 1987; 162:11-17.
5. FISCHER J: Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: Biochemical and physicochemical investigations. Biochem J 1995; 312: 215-222.
6. FISCHER J: Drug-induced glycosaminoglycan storage: Dose-dependent changes in the pattern of accumulated glycosaminoglycans in cultured bovine and human fibroblasts. Biochem Pharmacol 1996; 52: 1331-1337.
7. FISCHER J, LüLLMANN H, LÜLLMANN-RAUCH R: Drug-induced lysosomal storage of sulphated glycosaminoglycans. Gen Pharmacol 1996; 27: 1317-1324.
8. FRATANTONI JC, HALL CW, NEUFELD EF: The defect in Hurler's and Hunter's syndromes: Faulty degradation of mucopolysaccharide. Proc Natl Acad Sei USA 1968; 60: 699-706.
9. GRAVE S, LüLLMANN-RAUCH R, OSTERKAMP G, PROKOPEK M: Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives. Toxicol Appl Pharmacol 1992; 114: 215-224.
10. HANDROCK K, LüLLMANN-RAUCH R, VOGT RD: Drug-induced lysosomal storage of sulfated glycosaminoglycans. Studies on the underlying structure-activity relationships. Toxicology 1993; 85: 199-213.
11. KJELLEN L, LINDAHL U: Proteoglycans: Structures and interactions. Ann Rev Biochem 1991; 60: 443-475.
12. KRESSE H, HAUSNER H, SCHöNHERR E: Small proteoglycans. Experientia 1993; 49: 403-416.
13. LüLLMANN-RAUCH R.: Keratopathy in rats after treatment with tilorone. Graefe's Arch Clin Exp Ophthalmol 1986; 224: 377-383.
14. LÜLLMANN-RAUCH R, ZIEGENHAGEN M: Drug-induced lysosomal storage of sulfated glycosaminoglycans in cultured bovine and human fïbroblasts. Virchows Arch B Cell Pathol 1991; 60: 99-104.
15. LüLLMANN-RAUCH R, PODS R, VON WITZENDORFF B: Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion. Biochem Pharmacol 1995; 49: 1223-1233.
16. MAClNTYRE A, CUTLER DJ: The potential role of lysosomes in tissue distribution of weak bases. Biopharmac Drug Dispos 1988; 9: 513-526.
17. MAClNTYRE A, CUTLER DJ: Role of lysosomes in hepatic accumulation of chloroquine. J Pharmac Sei 1988; 77: 196-199.
18. th ed, pp 2465-2494.
19. OHKUMA S, POOLE B: Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances. J Cell Biol 1981; 90: 656-664.
20. PROKOPEK M.: The tilorone-induced mucopolysaccharidosis in rats. Biochem Pharmacol 1991; 42:2187-2191.
21. RORIG KJ, RUBEN Z, ANDERSON SN: Structural determinants of cationic amphiphilic amines which induce clear cytoplasmic vacuoles in cultured cells (42462). Proc Soc Exp Biol Med. 1987; 184: 165-171.
22. SCHMIDT G, HAUSSER H, KRESSE H: Extracellular accumulation of small dermatan sulphate proteoglycan II by interference with the secretion-recapture pathway. Biochem J 1990; 266: 591-595.
23. SCOTT JE, ORFORD CR, HUGHES EW: Proteoglycan-collagen arrangements in developing rat tail tendon. Biochem J 1981; 195: 573-581.
24. WEISS JN, WEINBERG RS, REGELSON W: Keratopathy after oral administration of tilorone hydrochloride. Am J Ophthalmol 1980; 89: 46-53.
25. WESSLER E: Analytical and preparative separation of acidic glycosaminoglycans by electrophoresis in barium acetate. Anal Biochem 1968; 26: 439-444.
26. WiBoM, POOLE B : Protein degradation in cultured cells: II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin Bl. J Cell Biol 1981; 63: 430-440.