In vitro activity of a new triazole antifungal agent, Sch 56592, against clinical isolates of filamentous fungi

Mycopathologia

Volumn 141, Issue 2, 1998, Pages 73-77

  Marco, F ^a,b   Pfaller, M A ^a   Messer, S A ^a   Jones, R N ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCYTOSINE; ITRACONAZOLE; POSACONAZOLE; TRIAZOLE DERIVATIVE;

ARTICLE; DRUG EFFECT; FUNGUS; HUMAN; MICROBIOLOGICAL EXAMINATION;

AMPHOTERICIN B; ANTIBIOTICS, ANTIFUNGAL; ANTIFUNGAL AGENTS; FLUCYTOSINE; FUNGI; HUMANS; ITRACONAZOLE; MICROBIAL SENSITIVITY TESTS; TRIAZOLES;

ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; ASPERGILLUS TERREUS; FUNGI; FUSARIUM; PAECILOMYCES; PSEUDALLESCHERIA BOYDII; RHIZOPUS; TRICHODERMA;

EID: 0031654590     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006970503053     Document Type: Article

References (12)

1. Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K. Trends in the post-mortem epidemiology of invasive fungal infections at a universitary hospital. J Infect 1996; 33: 23-32.
2. Saksena AK, Girijavallabhan VM, Lovey RO, Bennet F, Pike RB, Wang H, Pinto P, Liu YT, Patel N, Ganguly AK. Novel analogs of Sch 51048: synthesis and preliminary structure activity relationships. Abstract F83, 1995; 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA.
3. Pfaller MA, Messer SA, Jones RN. Activity of a new triazole, Sch 56592, compared with those of four other antifungal agents tested against clinical isolates of Candida spp. and Saccharomyces cerevisiae. Antimicrob Agents Chemother 1997; 41: 233-235.
4. Galgiani JH, Lewis ML. In vitro studies of activities of the antifungal triazoles Sch 56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts. Antimicrob Agents Chemother 1997; 41: 180-183.
5. Perfect JR, Cox GM, Dodge RK, Schell WA. In vitro and in vivo efficacies of the azole Sch 56592 against Cryptococcus neoformans. Antimicrob Agents Chemother 1996; 40: 1910-1913.
6. Moss Jr EL, Menzel Jr F, Norris C, Michalski M, Cacciapuoti AF, Nomeir A, Loebenberg D, Hare RS, Miller GH. Efficacy of Sch 56592 against fungal infections in guinea pigs. Abstract B 17, 1997; 37th Interscience Conference on Antimicrobial Agents and Chemotherapy,Toronto, Ontario, Canada.
7. Oakley KL, Moore CB, Denning DW. In vitro activity of Sch 56592 and comparison with activities of amphotericin B and itraconazole against Aspergillus spp. Antimicrob Agents Chemother 1997; 41: 1124-1126.
8. Laughlin M, Pai S, Menon S, Nomeir A, Colucci R, Affrime M, Kosoglou T. Rising multiple-dose safety, tolerance, and pharmacokinetic evaluation in healthy volunteers. Abstract A87, 1997; 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto, Ontario, Canada.
9. National Committee for Clinical Laboratory Standards (NCCLS) Reference method for broth dilution antifungal susceptibility testing of yeast. Approved standard M27-A. Wayne, PA: NCCLS, 1997.
10. Espinel-Ingroff A, Bartlett M, Bowden R, Chin NX, Cooper C, Fothergill A, McGinnis MR, Menezes P, Messer SA, Nelson PW, Odds FC, Pasarell L, Peter J, Pfaller MA, Rex JH, Rinaldi MG, Shankland GS, Walsh TJ, Weitzman I. Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi. J Clin Microbiology 1997; 35: 139-143.
11. Espinel-Ingroff A. Evaluation of the in vitro activity of three new antifungal agents against opportunistic filamentous and dimorphic fungi. Abstract F68, 1997; 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto, Ontario, Canada.
12. Oakley KL, Morrissey G, Denning DW. Efficacy of Sch 56592 in a temporarily neutropenic murine model of invasive aspergillosis with an itraconazole-susceptible and an itraconazole-resistant isolate of Aspergillus fumigatus. Antimicrob Agents Chemother 1997; 41: 1504-1507.