Placebo run-in period in studies of depressive disorders. Clinical, heuristic and research implications

British Journal of Psychiatry

Volumn 173, Issue SEPT., 1998, Pages 242-248

  Quitkin, F M ^a,b   McGrath, P J ^a   Stewart, J W ^a   Ocepek Welikson, K ^a   Taylor, B P ^a   Nunes, E ^a   Delivannides, D ^a   Agosti, V ^a   Donovan, S J ^a   Ross, D ^a   Petkova, E ^a   Klein, D F ^a  

^a The New York Presbyterian Hospital   (United States)

^b Box 12 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO;

ADULT; ARTICLE; CHRONICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RESEARCH; PROGNOSIS; REMISSION; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME;

EID: 0031654511     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.173.3.242     Document Type: Article

References (25)

1. Ainslie, J. D., Jones, M. B. & Stiefel, J. R. (1945) Practical drug evaluation method. Archives of General Psychiatry, 12, 368-373.
2. Alexander, F. & French, T. M. (1946) Psychoanalytic Therapy. New York: Ronald Press.
3. American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III).Washington, DC: APA.
4. _ (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R).Washington, DC: APA.
5. Bielski, R. J. & Friedel, R. O. (1976) Prediction of tricyclic antidepressant response. Archives of General Psychiatry, 33, 1479-1489.
6. Brown, W. A., Durnseif, B. E. & Wernicke, J. F. (1988) Placebo response in depression: a search for predictors. Psychiatry Research, 26, 259-264.
7. Derogatis, L. R., Upman, R. S., Rickeis, K., et al (1974) The Hopkins symptom checklist (HSCL): a self-report symptom inventory. Behavioral Science, 19, 1-15.
8. Fleiss, J. L. (1986) The Design and Analysis of Clinical Experiments. New York: Wiley & Sons Inc.
9. Friedman, L. M., Furberg, C. D. & Demets, K. L. (1985) Fundamentals in Clinical Trials (2nd edn). Littleton, MA: PSG Publishing.
10. Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Revised DHEW Pub. (ADM). Rockville, MD: National Institute for Mental Health.
11. Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278-296.
12. Joyce, P. R. & Paykel, E. D. (1989) Predictors of drug response in depression. Archives of General Psychiatry, 46, 88-89.
13. Klerman, G. L., Dimascio, A., Weissman, M., et al (1974) Treatment of depression by drugs and psychotherapy. American journal of Psychiatry, 131, 186-191.
14. McGrath, P. J., Quitkin, F. M., Stewart, J. W., et al (1981) An open clinical trial of mianserin. American Journal of Psychiatry, 138, 530-532.
15. _, Rabkin, J. G., Stewart, J. W., et al (1985) Placebo-controlled study of mianserin in depressed out-patients. Neuropsychobiology 14, 128-132.
16. Quitkin, F. M., Stewart, J. W., McGrath, P. J., et al (1993) Columbia atypical depression. A subgroup of depressives with better response to MAOI than to tricyclic antidepressants or placebo. British Journal of Psychiatry 163 (suppl. 21), 30-34.
17. Rabkin, J. G. (1987) Baseline characteristics of 10-day placebo washout responder in antidepressant trials. Psychiatry Research, 21, 9-22.
18. Reimherr, F. W., Ward, M. F. & Byerley, W. R. (1989) The introductory placebo washout: a retrospective evaluation. Psychiatry Research, 30, 191-199.
19. Spitzer, R., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773-782.
20. Stassen, H. H., Angst, J. & Delini-Stula, A. (1994) Severity at baseline and onset of improvement in depression. Meta-analysis of imipramine and moclobemide versus placebo. European Psychiatry, 9, 129-136.
21. Stewart, J. W., Quitkin, F. M., Fyer, A., et al (1980) Efficacy of desipramine in endogenmorphically depressed patients. Journal of Affective Disorders, 2, 165-176.
22. _, _, McGrath, P. J., et al (1981) Efficacy of desipramine in mildly depressed patients: a double-blind placebo-controlled trial. Psychopharmacology Bulletin, 17, 159-161.
23. _, McGrath, P. J., Quitkin, F. M., et al (1989) Relevance of DSM-III depressive subtype and chronicity of antidepressant efficacy in atypical depression: differential response to phenelzine, imipramine and placebo. Archives of General Psychiatry, 46, 1080-1087.
24. _, _, Rabkin, J. G., et al (1993) Atypical depression: a valid clinical entity? Psychiatric Clinics of North America, 16, 479-495.
25. Trivedi, M. H. & Rush, J. (1994) Does a placebo run-in or a placebo treatment cell affect the efficacy of antidepressant medications? Neuropsychopharmacology, 11, 33-42.