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Volumn 8, Issue 6, 1998, Pages 770-776

Learning in the oculomotor system: From molecules to behavior

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; BEHAVIOR; CEREBELLUM CORTEX; CORNEA REFLEX; EYE MOVEMENT; GUINEA PIG; LEARNING; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; OCULOMOTOR SYSTEM; PRIORITY JOURNAL; REVIEW; SACCADIC EYE MOVEMENT; SIGNAL PROCESSING; VISUAL ADAPTATION; ZEBRA FISH;

EID: 0031646842     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80120-7     Document Type: Article
Times cited : (19)

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    • of outstanding interest. This work compares the induction of learning in vivo to the requirements for induction of synaptic plasticity in vitro. It examines the patterns of neural activity present in the cerebellar cortex and vestibular nuclei during a range of stimuli that induce VOR adaptation. Patterns of neural activity that are consistently present during learning are identified as candidates for the in vivo trigger of synaptic plasticity.
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    • Multiple subclasses of Purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex
    • of outstanding interest. This study demonstrates that different subclasses of Purkinje cells in the floccular complex all receive similar information about the change in VOR gain required to improve image stability on the retina. These findings extend the results about the neural signals available to guide learning obtained for horizontal gaze velocity Purkinje cells [35].
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    • of outstanding interest. Cautions that a loss of VOR adaptation in mutant mice can only be interpreted by analyzing the detailed workings of the neural circuit for the VOR in vivo, in both wild-type and mutant mice. A similar caution applies to any attempt to use genetically manipulated animals to establish molecular mechanisms of learning.
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