SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Douglas, Stephen A ^a   Nichols, Andrew J ^a   Feuerstein, Giora Z ^a   Elliott, John D ^a   Ohlstein, Eliot H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Arrhythmia; Cardiac; Coronary; Endothelin; ETA B antagonist; SB 209670

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; INDAN DERIVATIVE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CORONARY ARTERY BLOOD FLOW; DOG; DRUG ANTAGONISM; DRUG EFFECT; GENERAL ANESTHESIA; HEART ARRHYTHMIA; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; VASOCONSTRICTION; VASODILATATION;

ANESTHESIA, GENERAL; ANIMALS; ARRHYTHMIA; CORONARY CIRCULATION; DOGS; ENDOTHELIN-1; HEMODYNAMIC PROCESSES; INDANS; INJECTIONS, INTRAVENOUS; RECEPTORS, ENDOTHELIN; VASOCONSTRICTION; VASODILATION;

EID: 0031639179     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00030     Document Type: Article

References (5)

1. Ohlstein EH, Douglas SA, Brooks DP, et al. Functions mediated by peripheral endothelin receptors. In: Ruffolo RR Jr, ed. Endothelin receptors: from the gene to the human. Boca Raton, CRC Press, FL: 1995:109-86.
2. Ohlstein EH, Nambi P, Douglas SA, et al. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci USA 1995;91:8052-6.
3. Nichols AJ, Koster PF, Ohlstein EH. The effect of diltiazem on the coronary haemodynamic and cardiac functional effects produced by intracoronary administration of endothelin-1 in the anaesthetized dog. Br J Pharmacol 1990;99:597-601.
4. Garjani A, et al. Effects of endothelin-1 and the ETA-receptor antagonist, BQ123, on ischemic arrhythmias in anesthetized rats. J Cardiovasc Pharmacol 1995;25:634-42.
5. Yorikane R, Koike H. The arrhythmogenic action of endothelin in rats. Jpn J Pharmacol 1990;53:259-63.