Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Cao, Wei Biao ^a   Zeng, Zheng Pei ^a   Zhu, Yuan Jue ^a   Luo, Wei Ci ^a   Demura, Hiroshi ^b   Naruse, Mitsuhide ^b   Shi, Yi Fan ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Endothelin 1; Hypoxia; Pulmonary hypertension; Tetramethylpyrazine

Indexed keywords

ENDOTHELIN 1; HERBACEOUS AGENT; PYRAZINE DERIVATIVE; TETRAMETHYLPYRAZINE; VASODILATOR AGENT;

ANIMAL; ANOXIA; ARTICLE; BLOOD; BLOOD PRESSURE; DOG; DRUG EFFECT; GENERAL ANESTHESIA; HEMODYNAMICS; LUNG ALVEOLUS; LUNG CIRCULATION; LUNG DISEASE; PATHOPHYSIOLOGY; VASCULAR RESISTANCE;

ANESTHESIA, GENERAL; ANIMALS; ANOXIA; BLOOD PRESSURE; DOGS; DRUGS, CHINESE HERBAL; ENDOTHELIN-1; HEMODYNAMIC PROCESSES; LUNG DISEASES; PULMONARY ALVEOLI; PULMONARY CIRCULATION; PYRAZINES; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0031638485     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00130     Document Type: Article

References (10)

1. Pang PK, Shan JJ, Chiu KW. Tetramethylpyrazine, a calcium antagonist. Planta Med 1996;62:431-5.
2. Zou AP, Wang DX, Wu F. Effect of tetramethylpyrazine on acute and chronic hypoxic pulmonary hypertension of the rat. J Tongji Med U 1986;6:133-7.
3. Peng W, Duan SF. Evaluation of the immediate effect of ligustrazine in chronic cor pulmonale. Chung Hua Nei Ko Tsa Chih 1989; 28:93-4.
4. Shirakami G, Nakao K, Saito Y, et al. Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats. Life Sci 1991;48:969-76.
5. Naruse M, Naruse K, Kurimoto F, et al. Radioimmunoiassay for endothelin and immunoreactive endothelin in culture medium of bovine endothelial cells. Biochem Biophys Res Commun 1989;160: 662-8.
6. Cao W, Luo WC, Guo ZJ, et al. Effects of ligustrazine and nitroglycerin on acute hypoxic pulmonary hypertension in mongrel dogs. Acta Acad Med Sin 1994;16:79-83.
7. Peng W, Hucks D, Priest RM, et al. Ligustrazine-induced endothelium-dependent relaxation in pulmonary arteries via an NO-mediated and exogenous L-arginine-dependent mechanism. Br J Pharmacol 1996;119:1063-71.
8. Deleuze PH, Adnot S, Shiiya N, et al. Endothelin dilates bovine pulmonary circulation and reverses hypoxic pulmonary vasoconstriction. J Cardiovasc Pharmacol 1992;19:354-60.
9. Bonvallet ST, Zamora MR, Hasunuma K, et al. BQ123, and ET-A receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol 1994;266:H1327-31.
10. Douglas SA, Vickery-Clark LM, Ohlstein EH. Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ123. Br J Pharmacol 1993;108:418-21.