Development of novel reversal agents, imidazothiazole derivatives, targeting MDR1- and MRP-mediated multidrug resistance

Oncology Research

Volumn 10, Issue 3, 1998, Pages 123-132

  Naito, Seiji ^a   Koike, Koji ^a   Ono, Mayumi ^a   Machida, Toshiki ^b   Tasaka, Shigeyuki ^b   Kiue, Akira ^b   Koga, Hirofumi ^a   Kumazawa, Joichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Nikken Chemicals Co   (Japan)

Author keywords

Imidazothiazole derivatives; MDR1; MRP; Multidrug resistance; P glycoprotein; Reversal agents

Indexed keywords

ABC TRANSPORTER; DOXORUBICIN; IMIDAZOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; THIAZOLE DERIVATIVE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CULTURE; CELL STRAIN KB; CROSS BREEDING; DBA MOUSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LEUKEMIA P 388; METABOLISM; MOUSE; MULTIDRUG RESISTANCE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CROSSES, GENETIC; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MDR; HUMANS; IMIDAZOLES; KB CELLS; LEUKEMIA P388; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM TRANSPLANTATION; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0031635486     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bradley, G.; Juranka, P. F.; Ling, V. Mechanism of multidrug resistance. Biochim. Biophys. Acta 948: 87-128; 1988.
2. Kohno, K.; Kikuchi, J.; Sato, S.; Takano, H.; Saburi, Y.; Asoh, K.; Kuwano, M. Vincristine-resistant human cancer KB cell line and increased expression of multidrug-resistance gene. Jpn. J. Cancer Res. 79: 1238-1246; 1988.
3. Hasegawa, S.; Abe, T.; Naito, S.; Kotoh, S.; Kumazawa, J.; Hipfncr, D. R.; Deeley, R. G.; Cole, S. P. C.; Kuwano, M. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines. Br. J. Cancer 71: 907-913; 1995.
4. Takano, H.; Kohno, K.; Ono, M.; Uchida, Y.; Kuwano, M. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells. Cancer Res. 51: 3951-3957; 1991.
5. Naito, S.; Sakamoto, N.; Kotoh, S.; Goto, K.; Matsumoto, T.; Kumazawa, J. Expression of P-glycoprotein and multidrug resistance in renal cell carcinoma. Eur. Urol. 24: 156-160; 1993.
6. Naito, S.; Kotoh, S.; Goto, K.; Koga, H.; Hasegawa, S.; Noma, H.; Yamasaki, T.; Kumazawa, J. Establishment of two human renal cell carcinoma cell lines with different chemosensitivity. Hum. Cell 9: 101-108; 1996.
7. Cole, S. P. C.; Bhardwaj, G.; Gerlach, J. H.; Mackie, J. E.; Grant, C. E.; Almquist, K. C.; Stewart, A. J.; Kurz, E. U.; Duncan, A. M.; Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654; 1992.
8. Krishnamachary, N.; Center, M. S. The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res. 53: 3658-3661; 1993.
9. Zaman, G. J. R.; Versantvoort, C. H. M.; Smit, J. J. M.; Eijdems, E. W. H. M.; de Haas, M.; Smith, A. J.; Broxterman, H. J.; Mulder, N. H.; de Vries, E. G. E.; Baas, F.; Borst, P. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res. 53: 1747-1750; 1993.
10. Barrand, M. A.; Heppell-Parton, A. C.; Wright, K. A.; Rabbitts, P. H.; Twenty man, P. R. A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to MRP gene. J. Natl. Cancer Inst. 86: 110-117; 1994.
11. Abe, T.; Hasegawa, S.; Taniguchi, K.; Yokomizo, A.; Kuwano, T.; Ono, M.; Mori, T.; Hori, S.; Kohno, K.; Kuwano, M. Possible involvement of mullidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Int. J. Cancer 58: 860-864; 1994.
12. Hyde, S. C.; Emsley, P.; Hartshorn, M. J.; Mimmack, M. M.; Gileadi, U.; Pearce, S. R.; Gallagher, M. P.; Gill, D. R.; Hubbard, R. E.; Higgins, C. F. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346: 362-365; 1990.
13. Tsuruo, T.; Iida, H.; Tsukagoshi, S.; Sakurai, Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 41: 1967-1972; 1981.
14. Rogan, A. M.; Hamilton, T. C.; Young, R. C.; Klecker, R. W., Jr.; Ozols, R. F. Reversal of Adriamycin resistance by verapamil in human ovarian cancer. Science 224: 994-996; 1984.
15. Cario, M. S.; Siegel, S.; Anas, N.; Sender, L. Clinical trial of continuous infusion vcrapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors. Cancer Res. 49: 1063-1066; 1989.
16. Kiue, A.; Sano, T.; Suzuki, K.; Inada, H.; Okumura, M.; Kikuchi, J.; Sato, S.; Kohno, K.; Kuwano, M. Activities of newly synthesized dihydropyridines in overcoming of vincristine resistance, calcium antagonism, and inhibition of photoaffinity labeling of P-glycoprotein in rodents. Cancer Res. 50: 310-317; 1990.
17. Kiue, A.; Sano, T.; Naito, A.; Inada, H.; Suzuki, K.; Okumura, M.; Kikuchi, J.; Sato, S.; Takano, H.; Kohno, K.; Kuwano, M. Reversal by two dihydropyridine compounds of resistance to multiple anticancer agents in mouse P388 leukemia in vivo and in vitro. Jpn. J. Cancer Res. 81: 1057-1064; 1990.
18. Watanabe, Y.; Takano, H.; Kiue, A.; Kohno, K.; Kuwano, M. Potentiation of etoposide and vincristine by two synthetic 1,4-dihydropyridine derivatives in multidrug-resistant and atypical multidrug-resislant human cancer cells. Anticancer Drug Desisn 6: 47-57; 1991.
19. Abe, T.; Koike, K.; Ohga, T.; Kubo, T.; Wada, M.; Kohno, K.; Mori, T.; Hidaka, K.; Kuwano, M. Chemosensilisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDRI. Br. J. Cancer 72: 418-423; 1995.
20. Koike, K.; Abe, T.; Hisano, T.; Kubo, T.; Wada, M.; Kohno, K.; Kuwano, M. Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins. Jpn. J. Cancer Res. 87: 765-772; 1996.
21. Naito, S.; Kanamori, T.; Hisano, S.; Tanaka, K.; Momose, S.; Kamata, N. Human renal cell carcinoma: Establishment and characterization of two new cell lines. J. Urol. 128: 1117-1121; 1982.
22. Naito, S.; von Eschenbach, A. C.; Giavazzi, R.; Fidler, I. J. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res. 46: 4109-4115; 1986.
23. Inaba, M.; Fujikura, R.; Sakurai, Y. Comparative study on in vivo development of resistance to various classes of antitumor agents in P388 leukemia. Jpn. J. Cancer Res. (Gann) 70: 607-613; 1979.
24. Tasaka, S.; Tanabe, H.; Sasaki, Y.; Machida, T.; Iino, M.; Kiue, A.; Naito, S.; Kuwano, M. Synthesis of 2-phenylimidazo[2,1-b] benzothiazole derivatives as a modulator of multidrug resistance for tumor cells. J. Heterocyclic Chem. 34: 1763-1767; 1997.
25. Akiyama, S.; Cornwell, M. M.; Kuwano, M.; Pastan, I.; Gottesman, M. M. Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. Mol. Pharmacol. 33: 144-147; 1988.
26. Safa, A. R.; Glover, C. J.; Sewell, J. L.; Meyers, M. B.; Biedler, J. L.; Felsted, R. L. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers. J. Biol. Chem. 262: 7884-7888; 1987.
27. Nogae, I.; Kikuchi, J.; Yamaguchi, T.; Nakagawa, M.; Shiraishi, N.; Kuwano, M. Potentiation of vincristine by vitamin A against drug-resistant mouse leukemia cells. Br. J. Cancer 56: 267-272; 1987.
28. Tsuruo, T.; Iida, H.; Tsukagoshi, S.; Sakurai, Y. Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res. 42: 4730-4733; 1982.
29. Akiyama, S.; Shiraishi, N.; Kuratomi, Y.; Nakagawa, M.; Kuwano, M. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluopcrazine, and chlorpromazine. J. Natl. Cancer Inst. 76: 839-844; 1986.
30. Shiraishi, N.; Akiyama, S.; Kobayashi, M.; Kuwano, M. Lysosomotropic agents reverse multiple drug resistance in human cancer cells. Cancer Lett. 30: 251-259; 1986.
31. Yamaguchi, T.; Nakagawa, M.; Shiraishi, N.; Yoshida, T.; Kiyosue, T.; Arita, M.; Akiyama, S.; Kuwano, M. Overcoming drug resistance in cancer cells with synthetic isoprenoids. J. Natl. Cancer Inst. 76: 947-953; 1986.
32. Nakagawa, M.; Akiyama, S.; Yamaguchi, T.; Shiraishi, N.; Ogata, J.; Kuwano, M. Reversal of multidrug resistance by synthetic isoprenoids in the KB human cancer cell line. Cancer Res. 46: 4453-4457; 1986.
33. Shiraishi, N.; Akiyama, S.; Nakagawa, M.; Kobayashi, M.; Ku-wano, M. Effect of bisbenzylisoquinoline (biscoclaurine) alkoloids on multidnig resistance in KB human cancer cells. Cancer Res. 47: 2413-2416; 1987.
34. Cornwell. M. M.; Pastan, I.; Gottesman, M. M. Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J. Biol. Chem. 262: 2166-2170; 1987.
35. Slovak, M. L.; Hoeltge, G. A.; Dalton, W. S.; Trent, J. M. Pharmacologic and biologic evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res. 48: 2793-2797; 1988.
36. Meijer, C.; Mulder, N. H.; Timmer-Bosscha, H.; Peters, W. H. M.; de Vries, E. G. E. Combined in vitro modulation of adriamycin resistance. Int. J. Cancer 49: 582-586; 1991.
37. Barrand, M. A.; Rhodes, T.; Center, M. S.; Twentyman, P. R. Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein. Eur. J. Cancer 29A: 408-415; 1993.
38. Cole, S. P. C.; Sparks, K. E.; Fraser, K.; Loe, D. W.; Grant, C. E.; Wilson, G. M.; Deeley, R. G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54: 5902-5910; 1994.