Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of early-onset non-insulin-dependent (type 2) diabetes mellitus in Japanese

Journal of Human Genetics

Volumn 43, Issue 2, 1998, Pages 107-110

  Nishigori, Hidekazu ^a   Yamada, Shirou ^a,b   Kohama, Tomoko ^b   Utsugi, Toshihiro ^b   Shimizu, Hiroyuki ^b   Takeuchi, Toshiyuki ^a   Takeda, Jun ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Direct sequencing; Maturity onset diabetes of the young (MODY); Mutation screening

Indexed keywords

DNA; DNA BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 1BETA; INSULIN; NUCLEAR PROTEIN; TCF1 PROTEIN, HUMAN; TCF2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; ARTICLE; ASIAN; CAUCASIAN; CHILD; COMPARATIVE STUDY; DOMINANT GENE; ETHNOLOGY; GENETICS; HEALTH SURVEY; HUMAN; JAPAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; ONSET AGE; POINT MUTATION; PREVALENCE; SECRETION;

ADOLESCENT; ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; DIABETES MELLITUS, TYPE 2; DNA; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENES, DOMINANT; HEALTH SURVEYS; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; INSULIN; JAPAN; NUCLEAR PROTEINS; POINT MUTATION; PREVALENCE; TRANSCRIPTION FACTORS;

EID: 0031626719     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050049     Document Type: Article

References (22)

1. Bell GI, Xiang K-S, Newman MV, Wu S-H, Wright LG, Fajans SS, Spielman RS, Cox NJ (1991) Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 88: 1484-1488
2. Byrne MM, Stuns J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ, Bain SC, Hattersley AT, Velho G, Froguel P, Bell GI, Polonsky KS (1996) Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 45: 1503-1510
3. Emens LA, Landers DW, Moss LG (1992) Hepatocyte nuclear factor la is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc Natl Acad Sci USA 89: 7300-7304
4. Fajans SS (1990) Scope and heterogeneous nature of MODY. Diabetes Care 13: 49-64
5. Frain M, Swart G, Monaci P, Nicosia A, Stamptti S, Frank R, Cortese R (1989) The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59: 145-157
6. Frayling TM, Bulman MP, Ellard S, Appleton M, Dronsfield MJ, Mackie ASR, Baird JD, Kaisaki PJ, Yamagata K, Bell GI, Bain SC, Hattersley AT (1997) Mutations in the hepatocyle nuclear factor-1α gene are a common cause of maturitv-onset diabetes of the young in the UK. Diabetes 46: 720-725
7. Froguel P, Velho G, Cohen D, Passa P (1991) Strategies for the collection sibling-pair data for genetic studies in type 2 (non insulin-dependent) diabetes mellitus. Diabetologia 34: 685
8. Glucksmann MA, Lehto M, Tayber O, Scotti S, Berkemeier L, Pulido JC, Wu Y, Nir W-J, Fang L, Markel P, Munnelly KD, Goranson J, Orho M, Young BM, Whitacre JL, McMenimen C, Wantman M, Tuomi T, Warram J, Forsblom CM, Carlsson M, Rosenzweig J, Kennedy G, Duyc GM, Krolewski AS, Groop LC, Thomas JD (1997) Novel mutations and a mutational hotspot in the MODY3 gene. Diabetes 46: 1081-1086
9. Hansen T, Eiberg H, Rouard M, Vaxxilaire M, Moller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hassen L, Bell GI, Pedersen O (1997) Novel MODY3 mutations in the hepatocyte nuclear factor-1α gene: Evidence for a hyperexcitability of pancreatic β-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation. Diabetes 46: 726-730
10. Ishiyama N, Kohama T, Kobayashi I, Nagashima K, Mori M, Kawazu S (1995) Epidemiological survey of young diabetic patients in Gunma Prefecture (in Japanese). Kitakanto Med J 45: 557-561
11. Iwasaki N, Oda N, Ogata M, Hara M, Hinokio Y, Oda Y, Yamagata K, Kanematsu S, Ohgawara H, Omori Y, Bell GI (1997) Mutations in the hepatocyle nuclear factor-1α/MODY3 gene in Japanese subjects with early-onset and late-onset NIDDM. Diabetes 46: 1504-1508
12. Kaisaki PJ, Menzel S, Lindner T, Oda N, Rjasanowski I, Sahm J, Meincke G, Schulze J, Schmechel H, Petzold C, Ledermann HM, Sachse G, Boriraj VV, Menzel R, Kerner W, Turner RC, Yamagata K, Bell GI (1997) Mutations in the hepatocyte nuclear factor-1α gene in MODY and early-onset NIDDM: Evidence for a mutational hotspot in exon 4. Diabetes 46: 528-535
13. Kosaka K, Hagure R, Kuzuya T (1977) Insulin responses in equivocal and definite diabetes, with special reference to subjects who had mild glucose intolerance but later developed definite diabetes. Diabetes 26: 944-952
14. Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reev-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC (1996) Mapping of a gene for type 2 diabetes mellitus associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 14: 90-94
15. Tronche F, Yaniv M (1992) HNF1, a homeoprotein member of the hepatic transcription regulatory network. Bioessays 14:579-589
16. Urhammer SA, Rasmussen SK, Kaisaki PJ, Oda N, Yamagata K, Moller AM, Fridberg M, Hansen L, Hansen T, Bell GI, Pedersen O (1997) Genetic variation in the hepatocyte nuclear factor-1α gene in Danish Caucasians with late-onset NIDDM. Diabetologia 40: 473-475
17. Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (1995) A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet 9: 418-423
18. Vaxillaire M, Rouard M, Yamagata K, Oda N, Kaisaki PJ, Boriraj VV, Chevre JC, Boccio V, Cox RD, Lathrop GM, Dussoix P, Philippe J, Timsit J, Charpentier G, Velho G, Bell GI, Froguel P (1997) Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). Hum Mol Genet 6: 583-586
19. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouah H, Lesage S, Velho G, Iris F, Passa P, Froguel P, Cohen D (1992) Nonsense mutation in the glucokinase gene causes early-onset non- insulm-dependent diabetes melhtus. Nature 356: 721-722
20. Yamada S, Nishigori H, Onda H, Takahashi K, Kitano N, Morikawa A, Takeuchi T, Takeda J (1997a) Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of late-onset NIDDM in Japanese subjects Diabetes 46: 1512-1513
21. Yamada S, Nishigori H, Onda H, Utsugi T, Yanagawa T, Maruyama T, Omgata K, Nagashima K, Nagai R, Morikawa A, Takeuchi T, Takeda J (1997b) Identification of mutations in the hepatocyte nuclear factor (HNF)-1α gene in Japanese subjects with IDDM. Diabetes 46: 1643-1647
22. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, LeBeau MM, Yamada S, Nishigori H, Takeda J, Chevre J-C. Fajans SS, Hattersley AT, Iwasaki N, Pedersen O, Polonsky KS, Turner RC, Froguel P, Bell GI (1996) Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384: 455-45