Preferential reduction in vascular responses to endothelin-1 in rats with streptozotocin-induced diabetes

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Guillon, J M ^a   Thiry, C ^a   Roach, A G ^a   Cavero, I ^a  

^a SANOFI   (France)

Author keywords

Acetylcholine; Anesthetized and pithed rats; Blood pressure; Bradykinin; Electrical stimulation of spinal sympathetic outflow; Endothelin 1; Norepinephrine; Streptozotocin diabetes

Indexed keywords

ACETYLCHOLINE; BRADYKININ; ENDOTHELIN 1; NORADRENALIN; VASOCONSTRICTOR AGENT;

ANIMAL; ARTICLE; BODY WEIGHT; DRUG EFFECT; ELECTROSTIMULATION; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; PATHOPHYSIOLOGY; RAT; SPINAL CORD; SPRAGUE DAWLEY RAT;

ACETYLCHOLINE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; BRADYKININ; DIABETES MELLITUS, EXPERIMENTAL; ELECTRIC STIMULATION; ENDOTHELIN-1; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; VASOCONSTRICTOR AGENTS;

EID: 0031618756     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00040     Document Type: Article

References (15)

1. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5.
2. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 1994;46:325-415.
3. Komata K, Miyata N, Kasuya Y. Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus. Life Sci 1992;50:1379-87.
4. Tomlinson KC, Gardiner SM, Hebden RA, Bennett T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol Rev 1992;44:103-50.
5. Öztürk Y, Altan VM, Yldizoglu-Ari N. Effects of experimental diabetes and insulin on smooth muscle function. Pharmacol Rev 1996;48:69-112.
6. Foy JM, Lucas PD. Effect of experimental diabetes, food deprivation and genetic obesity on the sensitivity of pithed rats to autonomic agents. Br J Pharmacol 1976;57:229-34.
7. Cavaliere TA, Taylor DG. The effects of insulin on vasoconstrictor responses in pithed rats. J Clin Pharmacol 1981;21:275-9.
8. Lucas PD. Effects of streptozotocin-induced diabetes and noradrenaline infusion on cardiac output and its regional distribution in pithed rats. Diabetologia 1985;28:108-12.
9. Heijnis JB, Mathy MJ, Pfaffendorf M, van Zwieten PA. Differential effects of alpha 2-adrenoceptor agonists on peripheral vasoconstriction in pithed diabetic rats. J Cardiovasc Pharmacol 1992; 20:554-8.
10. Beenen OH, Mathy MJ, Pfaffendorf M, van Zwieten PA. Influence of nifedipine on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed diabetic hypertensive rats. J Hypertens 1996;17(suppl 4):847-53.
11. G-nitro-L-arginine methyl ester on regional hemodynamics in conscious rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol 1991;103:1321-6.
12. Cameron NE, Dines KC, Cotter MA. The potential contribution of endothelin-1 to neuromuscular abnormalities in streptozotocin-diabetic rats. Diabetologica 1994;37:1209-15.
13. Stevens EJ, Tomlinson DR. Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes. Br J Pharmacol 1995;115:373-9.
14. Malik KU, McGiff JC. Relationship of glucose metabolism to adrenergic transmission in rat mesenteric arteries. Circ Res 1974; 35:553-74.
15. Langer SZ, Hicks PE. Alpha-adrenoceptor subtypes in blood vessels: physiology and pharmacology. J Cardiovasc Pharmacol 1984;6(suppl 4):S547-58.