Streptozotocin-Induced Diabetes Increases γ-Glutamyltranspeptidase Activity but not Expression in Rat Liver

Journal of Biochemical and Molecular Toxicology

Volumn 12, Issue 4, 1998, Pages 219-225

  Watkins III, John B ^a   Klaunig, James E ^b   Smith, Heather M ^a   Cornwell, Paul ^a   Sanders, Ruth A ^a  

^a Indiana University School of Medicine   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Gamma Glutamyltranspeptidase; Insulin Dependent Diabetes Mellitus; Liver; Rats; Streptozotocin

Indexed keywords

ANTIDIABETIC AGENT; GAMMA GLUTAMYLTRANSFERASE; INSULIN; MESSENGER RNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETICS; IMMUNOBLOTTING; LIVER; MALE; METABOLISM; RAT; REFERENCE VALUE; SPRAGUE DAWLEY RAT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HYPOGLYCEMIC AGENTS; IMMUNOBLOTTING; INSULIN; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER;

EID: 0031617109     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0461(1998)12:4<219::AID-JBT4>3.0.CO;2-O     Document Type: Article

References (43)

1. J. B. Watkins III and R. A. Sanders (1995). Diabetes mellitus-induced alterations of hepatobiliary function. Pharmacol. Rev., 47, 1-23.
2. J. B. Watkins III and S. E. Sherman (1992). Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin. J. Pharmacol. Exp. Ther., 260, 1337-1343.
3. N. P. Curthoys (1983). Role of gamma-glutamyltranspeptidase in the renal metabolism of glutathione. Miner. Electr. Meta., 9, 236-245.
4. S. S. Tate and A. Meister (1981). γ-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol. Cell. Biochem., 39, 357-368.
5. Y. Laperche, B. Frederique, T. Aissani, M. Chobert, M. Aggerbeck, J. Hanoune, and G. Guellanen (1986). Molecular cloning and nucleotide sequence of rat kidney γ-glutamyl transpeptidase cDNA. Proc. Natl. Acad. Sci. USA, 83, 937-941.
6. S. Horiuchi, M. Inoue, and Y. Morino (1978). γ-Glutamyl transpeptidase: sidedness of its active site on renal brush border membrane. Eur. J. Biochem., 87, 429-437.
7. G. V. Marathe, B. Nash, R. H. Haschemeyer, and S. S. Tate (1979). Ultrastructural localization of γ-glutamyl transpeptidase in rat kidney and jejunum. FEBS Lett., 107, 436-440.
8. M. H. Hanigan and H. C. Pitot (1985). γ-Glutamyl transpeptidase - its role in hepatocarcinogenesis. Carcinogenesis, 6, 165-172.
9. J. A. Goldbarg, O. M. Friedman, E. P. Pineda, E. E. Smith, R. Chatterji, E. H. Stein, and A. M. Rutenberg (1960). The colorimetric determination of γ-glutamyl transpeptidase with a synthetic substrate. Arch. Biochem. Biophys., 91, 61-70.
10. M. Nishimura, H. Stein, W. Berges, and R. Teschke (1981). γ-Glutamyltransferase activity of liver plasma membrane: induction following chronic alcohol consumption. Biochem. Biophys. Res. Commun., 99, 142-148.
11. D. Adjarov, E. Ivanor, M. Kerimova, and L. Lozanova (1983). Influence of fasting and of high protein on the activity of rat liver γ-glutamyltransferase. Experientia, 39, 498-499.
12. S. J. Hemmings and R. D. Pekush (1994). The impact of type I diabetes on rat liver γ-glutamyl transpeptidase. Mol. Cell. Biochem., 139, 131-140.
13. S. C. Lu, J. Kuhlenkamp, H. Wu, W.-M. Sun, L. Stone, and N. Kaplowitz (1997). Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am. J. Physiol., 272, G374-382.
14. S. V. McLennan, S. Heffernan, L. Wright, C. Rae, E. Fisher, D. K. Yue, and J. R. Turtle (1991). Changes in hepatic glutathione metabolism in diabetes. Diabetes, 40, 344-349.
15. S. J. Sulakhe, S. T. Tran, and V. B. Pulga (1990). Modulation of γ-glutamyltranspeptidase activity in rat liver plasma membranes by thyroid hormone. Int. J. Biochem., 22, 997-1004.
16. V. Prpic, K. C. Green, P. F. Blackmore, and J. H. Exton (1984). Vasopressin, angiotensin II and alpha-1-adrenergic induced inhibition of calcium transport by rat liver plasma membrane vesicles. J. Biol. Chem., 259, 1382-1385.
17. M. Inoue, R. Kinne, T. Tran, L. Bienpica, and I. M. Arias (1982). Rat liver canalicular membrane vesicles: isolation and topological characterization. J. Biol. Chem., 258, 5183-5188.
18. A. L. Meister, S. S. Tate, and O. W. Griffith (1981). γ-Glutamyltranspeptidase. Meth. Enzymol., 77, 237-253.
19. O. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall (1951). Protein measurements with Folin phenol reagent. J. Biol. Chem., 193, 265-275.
20. D. Oesterle, U. Gerbracht, E. Deml, B. Schlatterer, and E. Eigenbrodt (1989). Comparison of three rat liver foci bioassays - incidence of preneoplastic foci initiated by diethylnitrosamine. Carcinogenesis, 10, 1891-1895.
21. J. M. Chirgwin, A. E. Przybyla, R. J. MacDonald, and W. J. Rutter (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
22. P.C. Ferriola, C. Walker, A. T. Robertson, H. S. Earp, D. W. Rusnak, and P. Nettesheim (1989). Altered growth factor dependence and transforming growth factor gene expression in transformed rat tracheal epithelial cells. Mol. Carcinog., 2, 336-344.
23. M. J. Neveu, J. R. Hully, K. L. Babcock, E. L. Hertzberg, B. J. Nicholson, D. L. Paul, and H. C. Pitot (1994). Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver. J. Cell Sci., 107, 83-95.
24. A. S. Buyukdevrim (1994). Islet pathology in streptozotocin-induced auto-immune diabetic mice: new insights into clinical practice. Diab. Meta., 20, 87-94.
25. D. Loven, H. Schedl, H. Wilson, T. T. Daabees, L. D. Stegink, M. Diekus, and L. Oberley (1986). Effect of Insulin on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin-induced diabetes Diabetes, 35, 503-507.
26. S. C. Lu, J. Ge, J. Kuhlenkamp, and N. Kaplowitz (1992). Insulin and glucocorticoid dependence of hepatic γ-glutamylcysteine synthetase and glutathione synthesis in the rat: studies in cultured hepatocytes and in vivo. J. Clin. Invest., 90, 524-532.
27. A. K. Saxena, P. Srivastava, R. K. Kale, and N. Z. Baquer (1993). Impaired antioxidant status in diabetic rat liver: effect of vanadate. Biochem. Pharmacol., 45, 539-542.
28. A. C. Maritim, B. H. Moore, R. A. Sanders, and J. B. Watkins III (1997). Effects of melatonin on oxidative stress in streptozotocin-induced diabetic rats. Biochem. Pharmacol., submitted.
29. J. B. Watkins, P. D. Cornwell, H. M. Smith, R. A. Sanders, and J. E. Klaunig (1997). Streptozotocin-induced diabetes increases γ-glutamyltranspeptidase activity in rats. The Toxicologist, 36, 351.
30. R. A. Wapnir, V. J. Mancusi, and L. A. Goldstein (1982). Comparative ontogenesis of γ-glutamyl transpeptidase in rat tissues. Experientia, 38, 647-648.
31. H. Speisky, N. Shackel, G. Varghese, D. Wade, and Y. Israel (1990). Role of hepatic γ-glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver. Hepatology, 11, 843-849.
32. N. P. Curthoys and R. P. Hughey (1979). Characterization and physiological function of rat renal γ-glutamyltranspeptidase. Enzyme, 24, 383-403.
33. B. Mukherjee, J. R. Mukherjee, and M. Chatterjee (1994). Lipid peroxidation, glutathione levels and changes in glutathione-related enzyme activities in streptozotocin induced diabetic rats. Immunol. Cell. Biol., 72, 109-114.
34. A. Z. Albert, M. Orlowski, and A. Szewczuk (1961). Histochemical demonstration of γ-glutamyltranspeptidase. Nature, 191, 767-768.
35. H. Zarida, W. N. Wan Zurinah, J. Zanariah, L. K. Michael, and B. A. Khalid (1994). Effect of ovariectomy and sex hormones replacement on tumor marker enzymes under administration of chemical carcinogens in the rat. Exp. Toxicol. Pathol., 46, 31-36.
36. G. W. Lucier, A. Tritscher, T. Goldsworthy, J. Foley, G. Clark, J. Goldstein, and R. Maronpot (1991). Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res., 51, 1391-1397.
37. L. Accatino, C. Figueroa, M. Pizarro, and N. Sous (1995). Enhanced biliary excretion of canalicular membrane enzymes in estrogen-induced and obstructive cholestasis, and effects of different bile acids in the isolated perfused rat liver. J. Hepatol., 22, 658-70.
38. S. S. Tate, V. Khadse, and D. Wellner (1988). Renal γ-glutamyl transpeptidase structural and immunological studies. Arch. Biochem. Biophys., 262, 397-408.
39. V. J. Hunt, T. R. Dean, and P. S. Wolff (1988). Hydroxyl radical production and autoglycosylation. Biochem. J., 256, 205-212.
40. T. C. Blochberger, J. M. Sabatine, Y. H. Lee, and R. P. Hughey (1989). O-Linked glycosylation of rat renal γ-glutamyltranspeptidase adjacent to its membrane anchor domain. J. Biol. Chem., 264, 20718-20722.
41. M. F. Chaplin and J. F. Kennedy (eds.) (1994). Carbohydrate Analysis: A Practical Approach, 2nd ed., Oxford University Press, New York.
42. A. Amoresano, R. Siciliano, S. Orru, R. Napoleoni, V. Altaroccca, R. DeLuca, A. Sirna, and P. Pucci (1996). Structural characterization of human recombinant glycohormones follitropin, lutropin and choriogonadotropin expressed in Chinese hamster ovary cells. Eur. J. Biochem., 242, 608-618 (1996).
43. P. M. Rudd, H. C. Joao, E. Coghill, P. Fiten, M. R. Saunders, G. Opdenakker, and R. A. Dwek (1994). Glycoforms modify the dynamic stability and functional activity of an enzyme. Biochem., 33, 17-22 (1994).