Use of silica gels and mesoporous molecular sieves as supports for the solid-phase Claisen rearrangement

Molecular Diversity

Volumn 3, Issue 3, 1997, Pages 161-171

  Sucholeiki, Irving ^a,c   Pavia, Michael R ^a   Kresge, Charles T ^b   McCullen, Sharon B ^b   Malek, Andre ^b   Schramm, Suzanne ^b  

^a ELI LILLY AND COMPANY   (United States)

^b MOBIL TECHNOLOGY COMPANY   (United States)

^c Solid Phase Sciences Corporation   (United States)

Author keywords

Mesoporous; Silica; Solid phase Claisen rearrangement; Solid phase synthesis; Support

Indexed keywords

DIPHENYL ETHER DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; SILICA GEL; SILICON DIOXIDE;

ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; GEL; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; ORGANIC CHEMISTRY;

CHEMISTRY, ORGANIC; GELS; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENYL ETHERS; SILICON DIOXIDE;

EID: 0031615385     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009687028242     Document Type: Article

References (20)

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16. The unfunctionalized samples were vacuum dried at 300°C. The derivatized silica based supports were vacuum dried at 100°C in order to avoid decomposition.
17. 29)
18. As part of the synthesis of the mesoporous supports there is a calcination procedure requring heating at elevated temperatures (∼540°C), a process which might have resulted in the dehydration of some of the silanols.
19. Sample spinning = 4.0-4.5 kHz, recycle time = 800 s, tetramethylsilane was used as external standard.
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