De novo design and discovery of cyclic HIV protease inhibitors capable of displacing the active-site structural water molecule.

Pharmaceutical biotechnology

Volumn 11, Issue , 1998, Pages 257-284

  De Lucca, G V ^a   Jadhav, P K ^a   Waltermire, R E ^a   Aungst, B J ^a   Erickson Viitanen, S ^a   Lam, P Y ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; AZEPINE DERIVATIVE; DRUG DERIVATIVE; MOZENAVIR; PROTEINASE; PROTEINASE INHIBITOR; UREA;

ANIMAL; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG DESIGN; HUMAN; REVIEW; SYNTHESIS;

ANIMALS; AZEPINES; BINDING SITES; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; MOLECULAR CONFORMATION; UREA;

EID: 0031615010     PISSN: 10780467     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)