Expression and cytokine secretion in the states of immune reactivation in leprosy

Brazilian Journal of Medical and Biological Research

Volumn 31, Issue 1, 1998, Pages 69-76

  Sampaio, E P ^a   Sarno, E N ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Cytokines; Leprosy; Reactions

Indexed keywords

MYCOBACTERIUM LEPRAE;

CYTOKINE;

HUMAN; IMMUNOLOGY; LEPROSY; MYCOBACTERIUM LEPRAE; PATHOGENICITY; PHYSIOLOGY; REVIEW; SECRETION;

CYTOKINES; HUMANS; LEPROSY; MYCOBACTERIUM LEPRAE;

EID: 0031613889     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1998000100009     Document Type: Article

References (22)

1. Britton WJ (1993). Immunology of leprosy. Transactions of the Royal Society of Tropical Medicine and Hygiene, 87: 508-514.
2. De Vries RR (1991). Genetic control of immunopathology induced by Mycobacterium leprae. American Journal of Tropical Medicine and Hygiene, 44: 12-16.
3. Kaufmann SHE (1993). Immunity to intracellular bacteria. Annual Review of Immunology, 11: 129-163.
4. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronnenberg M, Brennan PJ & Modlin RL (1995). CD1 restricted T cell recognition of microbial lipoglycan antigens. Science, 269: 227-230.
5. Ramos T, Zalcberg-Quintana I, Appelberg R, Sarno EN & Silva MT (1989). T-helper cell subpopulations and the immune spectrum of leprosy. International Journal of Leprosy, 57: 73-81.
6. Alvarenga FBF (1995). Cellular immunity in reversal reaction: Immunohistochemical characterization in sequential cutaneous lesions. Doctoral thesis. Universidade Federal Fluminense, Rio de Janeiro.
7. Howe RC, Wondimu A, Demissee A & Frommel D (1995). Functional heterogeneity among CD4+ T cell clones from blood and skin lesions of leprosy patients. Identification of T cell clones distinct from Th10. Th1 and Th2. Immunology, 84: 585-594.
8. Mishra N, Murtaza A, Walker B, Narayan NPS, Mishra RS, Ramesh V, Singh S, Colston MJ & Nath I (1995). Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacierium leprae. Immunology, 86: 97-103.
9. Kaplan G, Weinstein DE, Steinman RM, Levis WR, Elvers V, Patarroyo ME & Cohn ZA (1985). An analysis of in vitro T cell responsiveness in lepromatous leprosy. Journal of Experimental Medicine, 159: 917-929.
10. Mohagheghpour N, Gelber RR & Engleman EG (1987). T cell defect in lepromatous leprosy is reversible in vitro in the absence of exogenous growth factors. Journal of Immunology, 138: 570-574.
11. Kaplan G, Nusrat A, Sarno EN, Job CK, McElrath J, Porto JA, Nathan CF & Cohn ZA (1987). Cellular responses to the intradermal injection of recombinant human γ-interferon in lepromatous leprosy patients. American Journal of Pathology, 128: 345-353.
12. Kaplan G, Sheftel G, Job CK, Mathur NK, Nath I & Cohn ZA (1988). Efficacy of a cell-mediated reaction to the purified protein derivative of tuberculin in the disposal of Mycobacterium leprae from human skin. Immunology, 85: 5210-5214.
13. Kaplan G, Kiessling R, Teklemariam S, Hancock G, Sheftel G, Job CK, Converse P, Ottenhoff THM, Belumink MB, Dietz M & Cohn ZA (1989). The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin-2. Journal of Experimental Medicine, 169: 893-907.
14. Convit J, Aranzazu N, Ubich M, Pinardi ME, Reyes O & Alvarado J (1982). Immunotherapy with mixture of Mycobacterium leprae and BCG in different forms of leprosy and in Mitsuda negative contacts. International Journal of Leprosy, 50: 415-424.
15. Laal S, Bhutani LK & Nath I (1985). Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum. Infection and Immunity, 50: 887-892.
16. Laal S, Mishra RS & Nath I (1987). Type I reactions in leprosy: Heterogeneity in T-cell functions related to the background leprosy type. International Journal of Leprosy, 55: 481-487.
17. Esquenazi D, Sampaio EP, Moreira AL, Gallo MEN, Almeida SMR & Sarno EN (1990). Effect of treatment on immune responsiveness in lepromatous leprosy patients. Leprosy Review, 61: 251-257.
18. Sarno EN, Grau GE, Vieira LMM & Nery JAC (1991). Serum levels of tumour necrosis factor-alpha and interleukin-1ß during leprosy reactional states. Clinical and Experimental Immunology, 84: 103-108.
19. Sampaio EP, Kaplan G, Miranda A, Nery JAC, Miguel CP, Viana SM & Sarno EN (1993). The influence of thalidomide on the clinical and immunological manifestation of erythema nodosum leprosum. Journal of Infectious Diseases, 168: 408-414.
20. Yamamura M, Wang X, Ohmen JD, Uyemura K, Rea TH, Bloom BR & Modlin RL (1992). Cytokine patterns of immunologically mediated tissue damage. Journal of Immunology, 149: 1470-1475.
21. Ehlers S & Smith KA (1991). Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. Journal of Experimental Medicine, 173: 25-36.
22. Sampaio EP, Moreira AL, Sarno EN, Malta AM & Kaplan G (1992). Prolonged treatment with recombinant Interferon γ induces erythema nodosum leprosum in lepromatous leprosy patients. Journal of Experimental Medicine, 175: 1729-1737.