A novel approach for inhibiting growth factor signalling in murine tooth development: Inhibition of FGF's

European Journal of Oral Sciences

Volumn 106, Issue 1 SUPPL., 1998, Pages 122-125

  Tucker, A S ^a   Markham, H J ^a   Green, P ^a   Doherty, P ^a   Sharpe, P T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Enamel knot; FGF; Tooth development

Indexed keywords

FGF4 PROTEIN, HUMAN; FGF4 PROTEIN, MOUSE; FGFR1 PROTEIN, HUMAN; FGFR1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; ONCOPROTEIN; PROTEIN; PROTEIN TYROSINE KINASE; SHH PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MSX1;

ANIMAL; ARTICLE; CELL STRAIN COS1; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IN SITU HYBRIDIZATION; IN VITRO STUDY; MANDIBLE; METABOLISM; MOUSE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; TOOTH DEVELOPMENT;

ANIMALS; COS CELLS; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION; MANDIBLE; MICE; MSX1 TRANSCRIPTION FACTOR; ODONTOGENESIS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0031613443     PISSN: 09098836     EISSN: 16000722     Source Type: Journal    
DOI: 10.1111/j.1600-0722.1998.tb02163.x     Document Type: Article

References (15)

1. POWNALL ME, TUCKER AS, SLACK JMW, ISAACS HV. eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development 1996; 122: 3881-3892.
2. NISWANDER L, TICKLE C, VOGEL A, BOOTH I, MARTIN GR. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the Limb. Cell 1993; 75: 579-587.
3. HEIKINHEIMO M, LAWSHE A, SHCKLEFORD GM, WILSON DB, MACARTHUR CA. FGF-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev 1994; 48: 129-138.
4. MACARTHUR CA, LAWSHE A, XU J, SANTOS-OCAMPO S, HEIKINHEIMO M, CHELLAIAH AR, ORNITZ DM. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 1995; 121: 3603-3613.
5. VAAHTOKARI A, ÅBERG T, JERNVALL J, KERÄNEN S, THESLEFF I. The enamel knot as a signaling center in the developing mouse tooth. Mech Dev 1996; 54: 39-43.
6. FELDMAN B, POUEYMIROU W, PAPAIOANNOU VE, DECHIARA TM, GOLDFARB M. Requirement of FGF-4 for postimplantation mouse development. Science 1995; 267: 246-249.
7. GREEN PJ, WALSH FS, DOHERTY P. Promiscuity of fibroblast growth factor receptors. BioEssays 1996; 18: 639-646.
8. YAMAGUCHI TP, HARPAL K, HENKEMEYER M, ROSSANT J. FGFR-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 1994; 8: 3032-3044.
9. DENG C-X, WYNSHAW-BORIS A, SHEN MM, BAUGHERTY C, ORNITZ DM, LEDER P. Murine FGFR-1 is required for early postimplantation growth and axial organisation. Genes Dev 1994; 8: 3045-3057.
10. MUENKE M, SCHELL U, HEHR A, ROBIN NH, WOLFGANG L, SCHINZEL A, PULLEYN LJ, RUTLAND P, REARDON W, MALCOLM S, WINTER RM. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nature Genetics 1994; 8: 269-274.
11. SIMMONS DL. Cloning cell surface molecules by transient expression in mammalian cells. In: HARTLEY D, ed. Cellular interactions in development. Oxford: Oxford University Press, 1993; 93-128.
12. TROWELL OA. The culture of mature organs in a synthetic medium. Exp Cell Res 1959; 16: 118-147.
13. SAXEN L, LEHTONEN E, KARKINEN-JAASKELAINEN M, NORDLING S, WARTIOVAARA J. Morphogenetic tissue interactions: mediation by transmissible signal substances or through cell contacts? Nature 1976; 259: 662-663.
14. WILKINSON DG. In situ hybridisation: a practical approach. Oxford: Oxford University Press, 1995.
15. MACKENZIE A, LEEMING GL, JOWETT AK, FERGUSON MWJ, SHARPE PT. The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 1991; 111: 269-285.