Pfmdr1 (Asn)1042(ASp) and (Asp)1246(Tyr) polymorphisms, thought to be associated with chloroquine resistance, are present in chloroquine-resistant and -sensitive Brazilian field isolates of Plasmodium falciparum

Experimental Parasitology

Volumn 88, Issue 1, 1998, Pages 64-68

  Povoa M M ^a   Adagu, I S ^b   Oliveira, S G ^a   Machado, R L D ^a   Miles, M A ^b   Warhurst, D C ^b  

^a INSTITUTO EVANDRO CHAGAS   (Brazil)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; CHLOROQUINE; MEFLOQUINE; QUININE;

ARTICLE; BRAZIL; DRUG RESISTANCE; GENETIC POLYMORPHISM; IN VITRO STUDY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SOUTH AMERICA; ANIMAL; DRUG EFFECT; GENETICS; HUMAN; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM; PROTOZOA;

AMODIAQUINE; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; HUMANS; MEFLOQUINE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; QUININE;

EID: 0031608778     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1998.4195     Document Type: Article

References (19)

1. Adagu I. S., Warhurst D. C., Carucci D. J., Duraisingh M. T. Pfmdr1Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene. 89:1995;132.
2. TxrPfmdr1. Transactions of the Royal Society of Tropical Medicine and Hygiene. 90:1996;90-91.
3. Adagu I. S., Ogala W. N., Carucci D. J., Duraisigh M. T., Warhurst D. C. Field chloroquine-resistance determinants. Annals of Tropical Medicine and Parasitology. 91:1997;S107-S111.
4. Awad-El-Kariem F. M., Miles M. A., Warhurst D. C. Chloroquine-resistantPlasmodium flaciparumPfmdr1. Transactions of the Royal Society of Tropical Medicine and Hygiene. 86:1992;587-589.
5. Basco L. K., Bras J. L., Rhoades Z., Wilson C. M. Analysis ofPfmdr1Plasmodium falciparum. Molecular and Biochemical Parasitology. 74:1995;157-166.
6. Cox-Singh J., Singh B., Alias A., Abdullah M. S. Assessment of the association between threePfmdr1in vitroPlasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene. 89:1995;436-437.
7. di Santi S. M., Boulos M., Vasconcelos M., Oliveira S., Couto A., Rosario V. E. Caracterizaçáo de cepas dePlasmodium falciparum. Revista do Instituto de Medicina Tropical de So Paulo. 29:1987;142-147.
8. di Santi S. M., Camargo Neves V. L. F., Boulos M., Dutra A. P., Ramos A. M. S. V., Santos M. A., Barata L. C. B. Avaliaçáo de resposta doPlasmodium falciparum. Revista do Instituto de Medicina Tropical de Sáo Paulo. 30:1988;147-152.
9. Foote S. J., Kyle D. J., Martin S. K., Oduola A. M. J., Forsyth K., Kemp D. J., Cowman A. F. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance inPlasmodium falciparum. Nature. 345:1990;255-258.
10. Frean J. A., Awad-El-Kariem F. M., Warhurst D. C., Miles M. A. Rapid detection ofPfmdr1Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene. 86:1992;29-30.
11. Peel S. A., Bright P., Yount B., Handy J., Baric R. S. A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (Pfmdr1Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene. 51:1994;648-658.
12. Rosario V. E. Caracterizaçáo de cepas dePlasmodium falciparum. Revista da Fundaçáo SESP. 28:1983;115-136.
13. van Es H. H. G., Karcz S., Chu F., Cowman A. F., Vidal S., Gros P., Schurr E. Expression of the plasmodialPfmdr1. Molecular and Cellular Biology. 14:1994a;2419-2428.
14. van Es H. H. G., Renkema H., Aerts H., Schurr E. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing thePfmdr1. Molecular and Biochemical Parasitology. 68:1994b;209-219.
15. Volkman S. K., Cowman A. F., Wirth D. F. Functional complementation of theste6Saccharomyces cerevisiaePfmdr1Plasmodium falciparum. Proceedings of the National Academy of Sciences, USA. 92:1995;8921-8925.
16. Warhurst D. C., Awad-El-Kariem F. M., Miles M. A. Simplified preparation of malaria blood samples for polymerase chain reaction. Lancet. 337:1991;303-304.
17. Wellems T. E., Panton L. J., Gluzman I. Y., do Rosario V. E., Gwadz R. W., Walker-Jonah A., Krogstad D. J. Chloroquine resistance not linked tomdrPlasmodium falciparum. Nature. 345:1990;253-255.
18. Wellems T. E., Walker-Jonah A., Panton L. J. Genetic mapping of the chloroquine-resistance locus onPlasmodium falciparum. Proceedings of the National Academy of Sciences, USA. 88:1991;3382-3386.
19. Wernsdorfer W. H., Kouznetsov R. L. Drug resistant malaria - Occurrence, control, surveillance. Bulletin of the World Health Organisation. 58:1980;341-352.