Is the Heart Preadapted to Hypoxia? Evidence from Fractal Dynamics of Heartbeat Interval Fluctuations at High Altitude (5,050 m)

Integrative Physiological and Behavioral Science

Volumn 33, Issue 1, 1998, Pages 9-40

  Meyer, M ^a,c   Rahmel, A ^c   Marconi, C ^b   Grassi, B ^b   Skinner, J E ^d   Cerretelli, P ^a,b  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b CNR   (Italy)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d Totts Gap Medical Research Laboratories   (United States)

Author keywords

1 f noise; Autonomic nervous system; Cardiac rhythm; Electrocardiography; Heart rate; High altitude; Non linear dynamics; Scaling properties

Indexed keywords

ADAPTATION; ADULT; ALGORITHM; ALTITUDE; ANOXIA; ARTICLE; CLINICAL TRIAL; ELECTROCARDIOGRAPHY; FEMALE; FRACTAL ANALYSIS; HEART; HEART RATE; HUMAN; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADAPTATION, PHYSIOLOGICAL; ADULT; ALGORITHMS; ALTITUDE; ANOXIA; ELECTROCARDIOGRAPHY; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; FRACTALS; HEART; HEART RATE; HUMANS; MALE;

EID: 0031603437     PISSN: 1053881X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02688673     Document Type: Article

References (46)

1. Bak, P., and Creutz, M. (1994). Fractals and self-organized criticality. In: A. Bunde and S. Havlin (eds.), Fractals in Science, pp. 27-47. New York: Springer.
2. Banchero, N. (1987). Cardiovascular response to chronic hypoxia. Annual Reviews of Physiology 49: 465-476.
3. Beran, J. (1994). Statistics for Long-Memory Processes. New York: Chapman & Hall.
4. Buldyrev, S.V., Goldberger, A.L., Havlin, S., Peng, C.-K., Stanley, H.E., Stanley, M.H.R., Simons, M. (1993). Fractal landscapes and molecular evolution: Modeling of the myosin heavy chain gene family. Biophysical Journal 65: 2673-2679.
5. Cerretelli, P. (1980). Gas exchange at high altitude. In: J.B. West (ed.), Pulmonary Gas Exchange, pp. 97-147. New York: Academic Press.
6. Cerretelli, P. and Hoppeler, H. (1996). Morphologic and metabolic response to chronic hypoxia: The muscle system. In Handbook of Physiology, Section IV. Environmental Physiology Vol. II. pp. 1155-1181. New York: Oxford University Press.
7. Elbert, T., Ray, W.J., Kowalik, Z.J., Skinner, J.E., Graf, K.E., Birnbaumer, N. (1994). Chaos and physiology. Deterministic chaos in excitable cell assemblies. Physiological Reviews, 74: 1-47.
8. Farinelli, C.C.J., Kayser, B., Binzoni, T., Cerretelli, P., Girardier, L. (1994). Autonomic nervous control of heart rate at altitude (5,050 m). European Journal of Applied Physiology 69: 502-507.
9. Glass, L. and Malta, C.P. (1990). Chaos in multi-looped negative feedback systems. Journal of Theoretical Biology 145: 217-223.
10. Goldberger, A.L., Rigney, D.R., Mietus, J., Antman, E.M., Greenwald, S. (1988). Nonlinear dynamics in sudden cardiac death syndrome: Heart rate oscillations and bifurcations. Experientia 44: 983-987.
11. Grassi, B., Marconi, C., Meyer, M., Rieu, M., Cerretelli, P. (1997). Gas exchange and cardiovascular kinetics upon different exercise protocols in heart transplant recipients. Journal of Applied Physiology 82: 1952-1962.
12. Hausdorff, J.M., Peng, C.-K., Ladin, Z., Wei, J.Y., Goldberger, A.L. (1995). Is walking a random walk? Evidence for long-range correlations in the stride interval of human gait. Journal of Applied Physiology 78: 349-358.
13. Hausdorff, J.M., Purdon, P.L., Peng, C.-K., Ladin, Z., Wei, J.Y., Goldberger, A.L. (1996). Fractal dynamics of human gait: Stability of long-range correlations in stride interval fluctuations. Journal of Applied Physiology 80: 1448-1457.
14. Hughson, R.L., Yamamoto, Y., McCullough, R.E., Sutton, J.R., Reeves, J.T. (1994). Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis. Journal of Applied Physiology 77: 2537-2542.
15. Kaplan, D.T. and Glass, L. (1995). Understanding Nonlinear Dynamics. New York: Springer.
16. Keshner, M.S. (1982). 1/f noise. Proceedings IEEE 70: 212-218.
17. Lipsitz, L.A., Hashimoto, F., Lubowsky, L.P., Mietus, J., Moody, G., Appenzeller, O., Goldberger, A.L. (1995). Heart rate and respiratory rhythm dynamics on ascent to high altitude. British Heart Journal 74: 390-396.
18. Luft, U. (1988). Medical research on Nanga Parbat. Annals of Sports Medicine 4: 213-223.
19. Malconian, M., Hultgren, H., Nitta, M., Anholm, J., Houston, C., Fails, H. (1990). The sleep electrocardiogram at extreme altitude (operation Everest II). American Journal of Cardiology 65: 1014-1020.
20. Malhotra, M.S., Sevamurthy, W., Purkayastha, S.S., Mukherjee, A.K., Mathew, L., Dua, G.L. (1976). Responses of the autonomic nervous system during acclimatization to high altitude in man. Aviation, Space & Environmental Medicine 47: 1076-1079.
21. Mazzeo, R.S., Bender, P.R., Brooks, G.A., Butterfield, G.E., Groves, B.M., Sutton, J.R., Wolfel, E.E., Reeves, J.T. (1991). Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. American Journal of Physiology 261: E419-E424.
22. Meyer, M., Marconi, C., Grassi, B., Rieu, M., Cerretelli, P., Cabrol, C. (1992). Adjustment of cardiac output to step exercise in heart transplant recipients. Applied Cardiopulmonary Pathophysiology 4: 213-223.
23. Meyer, M., Marconi, C., Ferretti, G., Fiocchi, R., Cerretelli, P., Skinner, J.E. (1996). Heart rate variability in the human transplanted heart: Nonlinear dynamics and QT vs RR-QT alterations during exercise suggest a return of neurocardiac regulation in long-term recovery. Integrative Physiological and Behavioral Science 31:289-305.
24. Murphy, D.A., O'Blenes, S., Hanna, B.D., Armour, J.A. (1994). Functional capacity of nicotine-sensitive canine intrinsic cardiac neurons to modify the heart. American Journal of Physiology 266: R1127-R1135.
25. Peng, C.-K., Buldyrev, S.V., Goldberger, A.L., Havlin, S., Simons, M., Stanley, H.E. (1993a). Finite size effects on long-range correlations: Implications for analyzing DNA sequences. Physical Review E 47: 3730-3733.
26. Peng, C.-K., Mietus, J., Hausdorff, J.M., Havlin, S., Stanley, H.E., Goldberger, A.L. (1993b). Long-range anti-correlations and non-Gaussian behavior of the heartbeat. Physical Review Letters 70: 1343-1346.
27. Peng, C.-K., Buldyrev, S.V., Havlin, S., Simons, M., Stanley, H.E., Goldberger, A.L. (1994). Mosaic organization of DNA nucleotides. Physical Review E 49: 1685-1689.
28. Peng, C.-K., Havlin, S., Stanley, H.E., Goldberger, A.L. (1995). Quantification of scaling exponents and crossover phenomena in non-stationary heartbeat time series. Chaos 5: 82-87.
29. Richalet, J.-P., Larmignat, P., Rathat, C., Keromes, A., Baud, P., Lhoste, F. (1988). Decreased cardiac responses to isoproterenol infusion in acute and chronic hypoxia. Journal of Applied Physiology 65: 1957-1961.
30. Samorodnitsky, G., and Taqqu, M.S. (1994). Stable Non-Gaussian Random Processes: Stochastic Models With Infinite Variance. New York: Chapman & Hall.
31. Schoene, R.B. (1982). Control of ventilation in climbers to extreme altitude. Journal of Applied Physiology 53: 886-890.
32. Skinner, J.E., Pratt, C.M., Vybiral, T. (1993). A reduction in the correlation dimension of heartbeat intervals precedes imminent ventricular fibrillation in human subjects. American Heart Journal 125: 731-743.
33. Skinner, J.E., Molnar, M., Tomberg, C. (1994). The point correlation dimension: Performance with non-stationary surrogate data and noise. Integrative Physiological and Behavioral Science 29: 217-234.
34. Skinner, J.E., and Kresh, J.Y. (1996). Self-organization in a simple biological system: The intrinsic cardiac nervous system. In: G. Mayer-Kress, H. Kantz, J. Kurths (eds.), Nonlinear Techniques in Physiological Time Series Analysis. New York: Springer.
35. Skinner, I.E., Zebrowski, J.J., Kowalik, Z.J. (1996). New nonlinear algorithms for analysis of heart rate variability: Low-dimensional chaos predicts lethal arrhythmias. In: G. Mayer-Kress, H. Kantz, J. Kurths (eds.), Nonlinear Techniques in Physiological Time Series Analysis. New York: Springer.
36. Stanley, H.E. (1971). Introduction to Phase Transitions and Critical Phenomena. New York: Oxford University Press.
37. Theiler, J., Eubank, S., Longtin, A., Galdrikian, B., Farmer, J.D. (1992). Testing for nonlinearity in time series: The method of surrogate data. Physika D 58: 77-94.
38. Ueda, G., Reeves, J.T., Sekiguchi, M. (1992). High Altitude Medicine. Matsumoto: Shinshu University Press.
39. Voss, R.F. (1988). Fractals in nature: From characterization to simulation. In H.O. Peitgen and D. Saupe (eds.), The Science of Fractal Images, pp. 21-70. New York: Springer.
40. Ward, M.P., Milledge, J.S., West, J.B. (1990). High Altitude Medicine and Physiology. Philadelphia: University of Pennsylvania Press.
41. West, B.J. (1990). Physiology in fractal dimensions: Error tolerance. Annals of Biomedical Engineering 18: 135-149.
42. Wolfel, E.E., Selland, M.A., Mazzeo, R.S., Reeves, J.T. (1994). Systemic hypertension at 4,300 m is related to sympathoadrenal activity. Journal of Applied Physiology 76: 1643-1650.
43. Yamamoto, Y., and Hughson, R.L. (1991). Coarse-graining spectral analysis: New method for studying heart rate variability. Journal of Applied Physiology 71: 1143-1160.
44. Yamamoto, Y., and Hughson, R.L. (1993). Extracting fractal components from time series. Physica D 68: 250-264.
45. Yamamoto, Y., Hughson, R.L., Sutton, J.R., Houston, C.S., Cymerman, A., Fallen, E.L., Kamath, M.V. (1993). Operation Everest II: An indication of deterministic chaos in human heart rate variability at simulated extreme altitude. Biological Cybernetics 69: 205-212.
46. Young, A.J., Young, P.M., McCullough, R.E., Moore, L.G., Cymerman, A., Reeves, J.T. (1991). Effect of beta-adrenergic blockade on plasma lactate concentration during exercise at high altitude. European Journal of Applied Physiology 63: 315-322.