Apoptosis-like changes in the lungs induced by cyclophosphamide and papain. I. An ultrastructural study

Journal of Submicroscopic Cytology and Pathology

Volumn 30, Issue 1, 1998, Pages 105-116

  Sulkowska, M ^a   Sulkuwski, S ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b NONE

Author keywords

Apoptosis; Cyclophosphamide; Lung; Papain; Ultrastructure

Indexed keywords

CYCLOPHOSPHAMIDE; PAPAIN;

ANIMAL; APOPTOSIS; ARTICLE; DRUG EFFECT; DRUG POTENTIATION; ELECTRON MICROSCOPY; ENDOTHELIUM; EPITHELIUM CELL; INJURY; LUNG; LUNG ALVEOLUS; MALE; RAT; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; APOPTOSIS; CYCLOPHOSPHAMIDE; DRUG SYNERGISM; ENDOTHELIUM; EPITHELIAL CELLS; LUNG; MALE; MICROSCOPY, ELECTRON; PAPAIN; PULMONARY ALVEOLI; RATS; RATS, WISTAR;

EID: 0031603013     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. ADAMSON I. and BOWDEN C., 1974. The type 2 cell as progenitor of alveolar epithelial regeneration: a cytodynamic study in mice after exposure to oxygen. Lab. Invest., 30, 35-42.
2. ADAMSON I.Y.R. and BOWDEN D.H., 1976. Pulmonary injury and repair. Organ culture studies of murine lung after oxygen. Arch. Pathol. Lab. Med., 100, 640-643.
3. ARENDS M.J., MORRIS R.J. and WYLLIE A.H., 1990. Apoptosis: the role of the endonuclease. Am. J. Pathol., 136, 593-608.
4. BARDALES R.H., XIE SU-SU, SCHAEFER R.F. and HSU SU-MING, 1996. Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am. J. Pathol., 149, 845-852.
5. BRUNO S., BINO G.D., LASSOTA P., GIARETTI W. and DARZYNKIEWICZ Z., 1992. Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Leukemia, 6, 1113-1120 .
6. CATLIN E.A., UITVLUGT N.D., DONAHOE P.K., POWELL D.M., HAYASHI M. and MACLAUGHLIN D.T., 1991. Müllerian inhibiting substance blocks epidermal growth factor receptor phosphorylation in fetal rat lung membranes. Metab. Clin. Exp., 40, 1178-1184.
7. COX G., GAULDIE J. and JORDANA M., 1992. Bronchial epithelial cell-derived cytokines (G-CSF and GM-CSF) promote the survival of peripheral blood neutrophils in vitro. Am. J. Respir. Cell. Mol. Biol., 7, 507-513.
8. CROUCH E.C., MOXLEY M.A. and LONGMORE W., 1987. Synthesis of collagenous proteins by pulmonary type II epithelial cells. Am. Rev. Respir. Dis., 135, 1118-1123.
9. DUNSMORE S.E. and RANNELS E., 1995. Turnover of extracellular matrix by type II pulmonary epithelial cells. Am. J. Physiol., 267, L336-L346.
10. FEDERSPIEL S.J., DIMARI S.J., HOWE A.M., GUERRY-FORCE M.L. and HARALSON M.A., 1991. Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. Lab. Invest., 64, 463-473.
11. FUKUDA Y., ISHIZAKI M., MASUDA Y., KIMURA G., KAWANAMI O. and MASUGI Y., 1987. The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am. J. Pathol., 126, 171-182.
12. GUINEE D. JR., FLEMING M., HAYASHI T., WOODWARD M., ZHANG J., WALLS J., KOSS M., FERRANS V. and TRAVIS W., 1996. Association of p53 and WAFI expression with apoptosis in diffuse alveolar damage. Am. J. Pathol., 149, 531-538.
13. HASCHEK W.M. and WITSCHI H.P., 1979. Pulmonary fibrosis: a possible mechanism. Toxicol. App. Pharmacol., 51, 475-487.
14. HAVRILESKY L.J., ELBENDARY A., HURTEAU J.A., WHITAKER R.S., RODRIGUEZ G.C. and BERCHUCK A., 1995. Chemotherapy-induced apoptosis in epithelial ovarian cancers. Obstet. Gynecol., 85, 1007-1010.
15. HEMPEL S.L., MONICK M.M. and HUNNINGHAKE G.W., 1996. Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages. Am. J. Respir. Cell. Mol. Biol., 14, 170-176.
16. HIRAMINE C., NAKAGAWA T., MIYAUCHI A. and HOJO K., 1996. Thymic nurse cells as the site of thymocyte apoptosis and apoptotic cell clearance in the thymus of cyclophosphamide-treated mice. Lab. Invest., 75, 185-201.
17. HOMMA S., NAGAOKA I., ABE H., TAKAHASHI K., SEYAMA K., NUKIWA T. and KIRA S., 1995. Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung. Am. J. Respir. Crit. Care Med., 152, 2084-2089.
18. HURLE J.M., 1988. Cell death in developing systems. Methods Achiev. Exp. Pathol., 13, 55-86.
19. KATZENSTEIN A.L. and ASKIN F.B., 1990. 'Surgical Pathology of Non-Neoplastic Lung Disease'. W.B. Saunders, Philadelphia, pp. 9-57.
20. KATZENSTEIN A.L., BLOOR C.M. and LIEBOW A.A., 1976. Diffuse alveolar damage: the role of oxygen, shock, and related factors. Am. J. Pathol., 85, 210-288.
21. KATZENSTEIN A.L., MYERS J.L. and MAZUR M.T., 1986. Acute interstitial pneumonia: a clinicopathologic, ultrastructural, and cell kinetic study. Am. J. Surg. Pathol., 10, 256-267.
22. KAUFMANN S., 1989. Induction of endonucleolytic cleavage in human acute myelogenous leukemia cells by etoposide, campothectin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res., 49, 58-70-5878.
23. KERR J.F.K., WYLLIE A.H. and CURRIE A.H., 1972. Apoptosis, a basic biological phenomenon with wider implications in tissue kinetics. Br. J. Cancer, 26, 239-245.
24. Wafl/Cip/Sdil and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med., 154 477-483.
25. KWO P., PATEL T., BRONK S. and GORES G., 1995. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes. Am. J. Physiol., 268, G613-G621.
26. LIBBY P.. FRIEDMAN G.B. and SALOMON R.N., 1989. Cytokines as modulators of cell proliferation in fibrotic diseases. Am. Rev. Respir. Dis., 140, 1114-1117.
27. MEYN R.E., STEPHENS L.C., HUNTER N.R. and MILAS L., 1995. Apoptosis in murine tumors treated with chemotherapy agents. Anticancer Drugs, 6, 443-450.
28. MOALLEM S.A. and HALES B.F., 1995. Induction of apoptosis and cathepsin D in limbs exposed in vitro to an activated analog of cyclophosphamide. Teratology, 52, 3-14.
29. OPPENHEIM R.W., QIN-WEI Y., PREVETTE D. and YAN Q., 1992. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature London, 360, 755-757.
30. PATEL J.M., 1987. Stimulation of cyclophosphamide-induced pulmonary microsomal lipid peroxidation by oxygen. Toxicology, 45, 79-91.
31. PATEL J.M., BLOCK E.R. and HOOD C.I., 1984. Biochemical indices of cyclophosphamide-induced lung toxicity. Toxicol. Appl. Pharmacol., 76, 128-138.
32. PATEL T., GORES G.J. and KAUFMANN S.H., 1989. The role of proteases during apoptosis. FASEB J., 10, 587-597.
33. PEREZ-POLO R., 1991. 'Mechanism of Cell Death'. Plenum, New York. pp. 345-352.
34. POLUNOVSKY V.A., WENDT C.H.. INGBAR D.H. and BITTERMAN P.B., 1992. New RNA or protein synthesis are not required for endothelial cell apoptosis by TNF. Mol. Biol. Cell., 3, 328a.
35. POLUNOVSKY V.A.. CHEN B., HENKE C., SNOVER D., WENDT C., INGBAR D.H. and BITTERMAN P.B., 1993. Role of mesenchymal cell death in lung remodeling after injury. J. Clin. Invest., 92, 388-397.
36. RATAN R.R., MURPHY T.H. and BARABAN J.M., 1994. Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem., 62, 376-379.
37. REED J.C., 1994. Bcl-2 and regulation of programmed cell death. J. Cell Biol., 124, 1-6.
38. ROBAYE B., MOSSELMANS R., FIERS W., DUMONT J.E. and GALAND P., 1991. Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro. Am. J. Pathol., 138, 447-453.
39. SAGE H., FARIN F.M., STRIKER G.E. and FISHER A.B., 1983. Granular pneumocytes in primary culture secrete several major components of the extracellular matrix. Biochemistry, 22, 2148-2155.
40. SHIMIZU T. and POMMIRR Y., 1996. DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor campothecin: cell-free system studies. Exp. Cell Res., 226, 292-301.
41. SHINAGAWA T., YOSHIOKA K., KAKUMU S., WAKITA T., ISHIKAWA T., ITOH Y. and TAKAYANAGI M., 1991. Apoptosis in cultured rat hepatocytes: the effects of tumor necrosis factor alpha and interferon gamma. J. Pathol., 165, 247-253.
42. SULKOWSKA M. and SULKOWSKI S., 1997. The contribution of type II pneumocytes and alveolar macrophages to fibroplasia processes in the course of enzymatic lung injury. Histol. Histopathol., 12, 111-122.
43. SULKOWSKA M., SULKOWSKI S. and DZIȨCIOL J., 1996a. Type II alveolar epithelial cells promote fibrosis during development of experimental lung emphysema. Folia Histochem. Cytobiol., 34, 27-28.
44. SULKOWSKA M., SULKOWSKI S., NOWAK H.F. and TERLIKOWSKI S., 1996b. Type II alveolar epithelial cells and free alveolar cells after intratumor TNF-α administration. Histol. Histopathol., 11, 633-640.
45. SULKOWSKI S., 1994. Ultrastructural analysis of the type II epithelial cells and free alveolar cells in experimental lung emphysema. Pol. J. Pathol., 45, 63-71.
46. SULKOWSKI S., NOWAK H.F. and SZYNAKA B., 1993/1994. Alveolar epithelial cells in experimental lung emphysema. Ultrastructural analysis of cells in situ in TEM. Exp. Toxicol. Pathol., 45, 513-518.
47. SULKOWSKI S., SULKOWSKA M. and TERLIKOWSKI S., 1997. Studies on pulmonary tissue after administration of mutein VI-hrecTNF-α into implantable experimental Morris hepatoma. Int. J. Tissue Reac., 18, 57-65.
48. UHAL B.D., JOSHI I., TRUE A.L., MUNDLE S., RAZA A., PARDO A. and SELMAN M., 1995. Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am. J. Physiol., 269, 819-828.
49. ULICH T.R., YI E.S., LONGMUIR K., YIN S., BILTZ R., MORRIS C.F., HOUSLEY R.M. and PIERCE G., 1994. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J. Clin. Invest., 94, 1298-1306.
50. WENDT C.H., POLUNOVSKY V.A., PETERSON M.S., BITTERMAN P.E. and INGBAR D.H., 1994. Alveolar epithelial cells regulate the induction of endothelial cell apoptosis. Am. J. Physiol., 267, 893-900.
51. WITSCHI H., 1990. Responses of the lung to toxic injury. Environ. Health Perpect., 85, 5-13.
52. WOOD K.A. and YOULE R.J., 1994. Apoptosis and free radicals. Ann. N. Y. Acad. Sci., 738, 400-407.
53. YAN Q., ELLIOTT J. and SNIDER W.D., 1992. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature London, 360, 753-755.
54. ZHANG J., WENTHOLD R.J., YU Z.X., HERMAN E.H. and FERRANS V.J., 1995. Characterization of the pulmonary lesions induced in rats by human recombinant interleukin-2. Toxicol. Pathol., 23, 653-666.