Interferon-alpha-induced Thyroid Dysfunction in Patients with Chronic Active Hepatitis C: A Transient, Reversible and Self-limited Dysfunction

Internal Medicine

Volumn 37, Issue 1, 1998, Pages 27-31

  Tsuboi, Kumiko ^a   Katayama, Masahiko ^a   Yuasa, Rena ^a   Matoba, Hana ^a   Nagayama, Toru ^a   Ihara, Fumic ^a   Ooya, Taeko ^a   Matsuo, Kenji ^a   Otsuka, Sachio ^a   Miyachi, Yukitaka ^a  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic thyroiditis; Hashimoto's thyroiditis; Hypothyroidism; Pre existent autoimmune thyroid disease; Silent thyroiditis; Thyrotoxicosis

Indexed keywords

ALPHA2A INTERFERON; THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; BLOOD; CLINICAL TRIAL; FEMALE; GOITER; HEPATITIS C; HUMAN; HYPOTHYROIDISM; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THYROID DISEASE; THYROIDITIS;

ADULT; AGED; AUTOIMMUNE DISEASES; FEMALE; GOITER; HEPATITIS C, CHRONIC; HUMANS; HYPOTHYROIDISM; INTERFERON ALFA-2A; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; THYROID DISEASES; THYROIDITIS; THYROTROPIN; THYROXINE;

EID: 0031602949     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.37.27     Document Type: Article

References (19)

1. Marazuela M, Garcia-Buey L, Gonzáles-Fernández B, et al. Thyroid autoimmune disorders in patients with chronic hepatitis C before and during interferon-α therapy. Clin Endocrinol (Oxf) 44: 635, 1996.
2. Imagawa A, Itoh N, Hanafusa T, et al. Autoimmune endocrine disease induced by recombinant interferon-α therapy for chronic active type C hepatitis. J Clin Endocrinol Metab 80: 922, 1995
3. Tran A, Quaranta JF, Benzaken S, et al. High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy. Hepatology 18: 253, 1993.
4. Nagayama Y, Ohta K, Tsuruta M, et al. Exacerbation of thyroid autoimmunity by interferon a treatment in patients with chronic viral hepatitis: our studies and review of the literature. Endocr J 41: 565, 1994.
5. Katabami S, Kamijo K, Kodama T, Fujisawa Y, Katanuma A, Yachi A. An episode of silent thyroiditis in a patient with chronic thyroiditis and papillary adenocarcinoma following alpha interferon treatment for hepatitis C. Endocrin J 40: 311, 1993.
6. Baudin E, Marcellin P, Pouteau M, et al. Reversibility of thyroid dysfunction induced by recombinant alpha interpheron in chronic hepatitis C. Clin Endocrinol (Oxf) 39: 657, 1993.
7. Primo J, Hinojosu J, Moles JR, et al. Development of thyroid dysfunction after α-interferon treatment of chronic hepatitis C. Am J Gastroenterol 88: 1976, 1993 (letter; comment).
8. Lisker-Melman M, Di Bisceglie AM, Usala SJ, Weintraub B, Murray LM. Hoofnagle JH. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. Gastroenterology 102: 2155, 1992.
9. Chung YH, Shong YK. Development of thyroid autoimmunity after administration of recombinant human interferon-α2b for chronic viral hepatitis. Am J Gastroenterol 88: 244, 1993.
10. Gisslinger H, Gilly B, Woloszczuk W, et al. Thyroid autoimmunity and hypothyroidism during long-term treatment with recombinant interferon-alpha. Clin Exp Immunol 90: 363, 1992.
11. Rönnblom LE, Alm GV, Öberg KE. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med 115: 178, 1991.
12. Sauter NP, Atkins MB, Mier JW, Lechan RM. Transient thyrotoxicosis and persistent hypothyroidism due to acute autoimmune thyroiditis after interleukin-2 and interferon-α therapy for metastatic carcinoma: a case report. Am J Med 92: 441, 1992.
13. Reid I, Sharpe I, McDevitt J, et al. Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon α-2a. Br J Cancer 64: 915, 1991.
14. Pichert G, Jost LM, Zöbeli L, Odermatt B, Pedio G, Stahel RA. Thyroiditis after treatment with interleukin-2 and interferon α-2a. Br J Cancer 62: 100, 1990.
15. Burman P, Tötterman TH, Öberg K, Karlsson FA. Thyroid autoimmunity in patients on long term therapy with leukocyte derived interferon. J Clin Endocrinol Metab 63: 1086, 1986.
16. Schultz M, Müller R, von zur Mühlen A, Brabant G. Induction of hyperthyroidism by interferon-α-2b. Lancet 1: 1452, 1989 (letter).
17. Tsuboi K, Matoba H, Yuasa R, Ihara F, Miyachi Y. Autoimmune thyroid disease in concealment-revealed by IFNα. J Endocrinol Invest 17 (Supple, I to no 6): 61, 1994.
18. Sato K, Miyakawa M, Demura H. Reversible, extremely severe hypothyroidism in a patient with chronic hepatitis C treated with interferon-α. Thyroid 6: 249, 1996.
19. Amino N, Mori H, Iwutani Y, et al. High prevalence of transient postpartum thyrotoxicosis and hypothyroidism. N Engl J Med 306: 849, 1982.