Improved High-Performance Liquid Chromatographic Assay for the Determination of Procainamide and Its N-Acetylated Metabolite in Plasma: Application to a Single-Dose Pharmacokinetic Study

Journal of Chromatographic Science

Volumn 36, Issue 1, 1998, Pages 49-54

  Lessard, Étienne ^a   Fortin, Anne ^a   Coquet, Agnès ^a   Bélanger, Pierre Maxime ^a   Hamelin, Bettina A ^a   Turgeon, Jacques ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACECAINIDE; ANTIARRHYTHMIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PROCAINAMIDE;

ACETYLATION; ARTICLE; BLOOD; CALIBRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; REGRESSION ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ACECAINIDE; ACETYLATION; ANTI-ARRHYTHMIA AGENTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INDICATORS AND REAGENTS; PROCAINAMIDE; REGRESSION ANALYSIS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0031602510     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/36.1.49     Document Type: Article

References (20)

1. J. Koch-Weser and S.W. Klein. Procainamide dosage schedules, plasma concentrations, and clinical effects. JAMA 215: 1454-60 (1971).
2. J.T. Bigger and R.H. Heissenbuttel. The use of procainamide and lidocaine in the treatment of cardiac arrhythmias. Prog. Cardiovasc. Dis. 11: 515-34 (1969).
3. J. Koch-Weser. Antiarrhythmic prophylaxis in ambulatory patients with coronary heart disease. Arch. Intern. Med. 129: 763-72 (1972).
4. A. Interian, L. Zaman, E. Velez-Robinson, P. Kozlovskis, A. Castellanos, and R.J. Myerburg. Paired comparisons of efficacy of intravenous and oral procainamide in patients with inducible sustained ventricular tachyarrhythmias. J. Am. Coll. Cardiol. 17: 1581-86 (1991).
5. R.E. Kates. Plasma level monitoring of antiarrhythmic drags. Am. J. Cardiol. 52: 8C-13C (1983).
6. J. Koch-Weser. Serum procainamide levels as therapeutic guides. Clin. Pharmacokinet. 2: 389-402 (1977).
7. K.M. Kessler, P. Ho-Tung, B. Steele, J. Silver, A. Pickoff, S. Narayanan, and R.J. Myerburg. Simultaneous quantitation of quinidine, procainamide, and N-acetylprocainamide in serum by gas-liquid chromatography with a nitrogen phosphorus selective detector. Clin. Chem. 28: 1187-90 (1982).
8. J.D. Coyle, J.J. MacKichan, H. Boudoulas, and J.J. Lima. Reversed-phase liquid chromatography method for measurement of procainamide and three metabolites in serum and urine: Percent of dose excreted as deethyl metabolites. J. Pharm. Sci. 76: 402-405 (1987).
9. D. Raphanaud, M. Borensztejn, J.P. Dupeyron, and F. Guyon. High performance liquid chromatography of procainamide and N-acetylprocainamide in human blood plasma. Ther. Drug Monit. 8: 365-67 (1986).
10. O.H. Weddie and W.D. Mason. Rapid determination of procainamide and its N-acetyl derivative in human plasma by high-pressure liquid chromatography. J. Pharm. Sci. 66: 874-75 (1977).
11. F.M. Steams. Determination of procainamide and N-acetylprocainamide by high performance liquid chromatography. Clin. Chem. 27: 2064-67 (1981).
12. C.N. Ou and V.L. Frawley. Theophylline, diphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay. Clin. Chem. 28: 2157-60 (1982).
13. R.R. Bridges and T.A. lennison. An HPLC method for the simultaneous quantitation of quinidine, procainamide, N-acetylprocainamide and disopyramide. J. Anal. Toxicol. 7: 65-68 (1983).
14. C.P. Patel. Improved liquid chromatographic determination of procainamide an N-acetylprocalnamide in serum. Ther. Drug. Monit. 5: 235-38 (1983).
15. G.R. Gotelli and J.H. Wall. Procainamide and N-acetylprocainamide by ultraviolet detection. Clin. Liq. Chromatogr. 1: 47-51 (1984).
16. T. Annesley, K. Matz, R. Davenport, and D. Giacherio. A high performance liquid chromatographic assay for tocainide with alternate application for the determination of lidocaine, procainamide and N-acetylprocainarnide. Res. Commun. Chem. Pathol. Pharmacol. 51: 173-81 (1986).
17. F. Jamali, R.S. Alballa, R. Mehvar, and C.H. Lemko. Longer plasma half-life for procainamide utilizing a very sensitive high performance liquid chromatography assay. Ther. Drug Monit. 10: 91-96 (1988).
18. C.A. Carries and J.D. Coyle. Evaluation of very rapid Emit Qst methods for measuring serum, procalnamide and N-acetylprocainamide concentrations. Pharmacotherapy 12: 40-44 (1992).
19. Y.W.F. Lam and C.E. Watkins. Fluorescence polarization immunoassay of quinidine, procainamide, and N-acetylprocainamide using Cobas-FP reagents. Clin. Pharm. 12: 49-52 (1993).
20. J.E. Knoll. Estimation of the limit of detection in chromatography. J. Chromatogr. Sci. 23: 422-25 (1985).