Identification of the Yc1 Glutathione S-Transferase mRNA as the Overexpressed Species in a Nitrogen Mustard-Resistant Rat Mammary Carcinoma Cell Line

Journal of Biochemical and Molecular Toxicology

Volumn 12, Issue 1, 1998, Pages 11-17

  Fotouhi Ardakani, Nasser ^a   Woo, Annie ^a   Lewandowska, Marlena ^a   Schecter, Robyn ^a   Batist, Gerald ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

cDNA isolation and sequencing; Glutathione; Melphalan resistance; S Transferase; Yc Isoform

Indexed keywords

BRASSICACEAE;

CHLORMETHINE; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; ISOENZYME; MESSENGER RNA;

ANIMAL; ARTICLE; CELL CULTURE; DRUG RESISTANCE; EXPERIMENTAL NEOPLASM; GENETICS; MOLECULAR CLONING; NORTHERN BLOTTING; PATHOLOGY; RAT;

ANIMALS; BLOTTING, NORTHERN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE TRANSFERASE; ISOENZYMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MECHLORETHAMINE; RATS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0031601650     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0461(1998)12:1<11::AID-JBT3>3.0.CO;2-S     Document Type: Article

References (19)

1. C. N. Robson, A. D. Lewis, C. R. Wolf, J. D. Hayes, S. J. Proctor, A. L. Harris, and I. D. Hickson, (1987). Reduced levels of drug induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity. Cancer Res., 47, 6022-6027.
2. R. L. Schecter, A. Woo, M. Duong, and G. Batist, (1991). In vivo and in vitro mechanisms of drug resistance in a rat mammary carcinoma model. Cancer Res., 51, 1434-1442.
3. K. D. Tew, (1994). Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 54, 4313-4320.
4. D. J. Meyer, K. S. Gilmore, J. M. Harris, J. A. Hartley, and B. Ketterer, (1992). Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferase. Br. J. Cancer, 66, 433-438.
5. J. D. Hayes and D. J. Pulford, (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol., 30, 445-600.
6. A. M. Gulick and W. E. Fahl, (1995). Forced evolution of glutathione S-transferase to create a more efficient drug detoxification enzyme. Proc. Natl. Acad. Sci. (U.S.A.), 92, 8140-8144.
7. C. B. Pickett, C. A. Telakowski-Hopkins, G. I.-F. Ding, L. Argenbright, and A. Y. H. Lu, (1984). Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNA's. J. Biol. Chem., 259, 5182-5188.
8. C. A. Telakowski-Hopkins, J. A. Rodkey, C. D. Bennett, A. Y. H. Lu, and C. B. Pickett, (1985). Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. J. Biol. Chem., 260, 5820-5825.
9. J. D. Hayes, T. Nguyen, D. J. Judah, D. G. Petersson, and G. E. Neal, (1994). Cloning of cDNA from fetal rat liver encoding Glutathione S-transferase Yc polypeptides. J. Biol. Chem., 269, 20707-20717.
10. J. D. Hayes, D. J. Judah, L. I. McLellan, L. A. Kerr, and S. D. Peacock, (1991). Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J., 279, 385-398.
11. R. L. Schecter, M. Alaoui-Jamali, A. Woo, W. E. Fahl, and G. Batist, (1993). Expression of a rat glutathione S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity. Cancer Res., 53, 4900-4906.
12. A. D. Lewis, I. D. Hickson, C. N. Robson, A. L. Harris, S. A. Griffiths, M. M. Manson, A. E. Hall, J. E. Moss, and C. R. Wolf, (1988). Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustard. Proc. Natl. Acad. Sci. (U.S.A.), 85, 8511-8515.
13. S. Letourneau, M. Greenbaum, R. L. Schecter, G. Batist, and D. Cournoyer, (1994). Retroviral gene transfer of GST-Yc confers resistance to alkylating agents. Cancer Res., 54, 4472-4481.
14. A. G. Hall, E. Matheson, I. D. Hickson, S. A. Foster, and L. Hogarth, (1994). Purification of an a class glutathione S-transferase from melphalan-resistant Chinese Hamster Ovary cells and demonstration of its ability to catalyze melphalan-glutathione adduct formation. Cancer Res., 54, 3369-3372.
15. G. L. Ellman, (1959). Tissue sulhydrals. Arch. Biochem. Biophys., 82, 70-77.
16. M. Alaoui-Jamali, L. Panasci, G. M. Centurioni, R. L. Schecter, S. L. Lehnert, and G. Batist, (1992). Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione S- transferase activity. Cancer Chemother. Pharmacol., 30, 341-347.
17. C. B. Pickett, C. A. Telakowski-Hopkins, A. M. Donohue, A. Y. H. Lu, and B. F. Hales, (1982). Differential induction of glutathione S-transferase subunits. Biochem. Biophys. Res. Commun., 104, 611-619.
18. J. Sambrook, E. F. Fritsch, and T. Maniatis, (1989). Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. G. Stenberg, M. Ridderstrom, A. Engstrom, S. E. Pemble, and B. Mannervik, (1992). Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds. Biochem. J., 284, 313-319.