CYP6D1 Protects Thoracic Ganglia of Houseflies from the Neurotoxic Insecticide Cypermethrin

Archives of Insect Biochemistry and Physiology

Volumn 37, Issue 1, 1998, Pages 57-63

  Korytko, Peter J ^a   Scott, Jeffrey G ^a  

^a Cornell University ^*  (United States)

Author keywords

Cytochrome p450; Detoxification; Insecticide; Nervous tissue; Pyrethroid resistance

Indexed keywords

MUSCA DOMESTICA;

CARBON; CIPERMETHRIN; CYP6D1 PROTEIN, MUSCA DOMESTICA; CYTOCHROME P450; INSECT PROTEIN; INSECTICIDE; PYRETHROID;

ANIMAL; ARTICLE; BIOTRANSFORMATION; DRUG EFFECT; ENZYMOLOGY; FEMALE; GANGLION; HOUSE FLY; METABOLISM; THORAX; WESTERN BLOTTING;

ANIMALS; BIOTRANSFORMATION; BLOTTING, WESTERN; CARBON RADIOISOTOPES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GANGLIA, INVERTEBRATE; HOUSEFLIES; INSECT PROTEINS; INSECTICIDES; PYRETHRINS; THORAX;

EID: 0031600133     PISSN: 07394462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6327(1998)37:1<57::AID-ARCH7>3.0.CO;2-S     Document Type: Article

References (27)

1. Hagedorn HH, Kunkel JG, Wheelock G (1978): The specificity of an antiserum against mosquito vitellogenin and its use in a radio-immunological precipitation assay for protein synthesis. J Insect Physiol 24:481-489.
2. Hodgson E (1984): Microsomal mono-oxygenases. In Kerkut GA, Gilbert LI (eds): Comprehensive Insect Physiology Biochemistry and Pharmacology; vol. 11, New York: Pergamon Press, pp 225-311.
3. Kao LR, Goldstein JA, Birnbaum LS (1986): Effect of o-benzyl-p-chlorophenol on drug metabolizing enzymes in rats. Biochem Pharmacol 35:613-620.
4. Korytko PJ (1997): CYP6D1 Protects Thoracic Ganglia of House Flies From the Neurotoxic Insecticide Cypermethrin. M.S. thesis, Cornell University, Ithaca, NY, 65 pp.
5. Laemmli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
6. Lee SST, Scott JG (1989): An improved method for preparation, stabilization, and storage of house fly (Diptera: Muscidae) microsomes. J Econ Entomol 82:1559-1563.
7. Lee SST, Scott JG (1992): Tissue distribution of microsomal cytochrome P 450 monooxygenases and their inducibility by phenobarbital in house fly, Musca domestica L. Insect Biochem Mol Biol 22:699-711.
8. Liu N, Scott JG (1995): Genetics of resistance to pyrethroid insecticides in the house fly, Musca domestica. Pestic Biochem Physiol 52:116-124.
9. Liu N, Scott JG (1996): Genetic analysis of factors controlling elevated cytochrome P450, CYP6D1, cytochrome b5, P450 reductase and monooxygenase activities in LPR house flies, Musca domestica. Biochem Genet 34:133-148.
10. Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF, Loper JC, Sato R, Waterman MR, Waxman DJ (1991): The P450 Superfamily: Update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol 10:1-14.
11. Omura T, Sato R (1964): The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
12. Oppenoorth FJ (1984): Biochemistry and genetics of insecticide resistance. In Kerkut GA, Gilbert LI (eds): Comprehensive Insect Physiology Biochemistry and Pharmacology; vol. 11, New York: Pergamon Press, pp 731-773.
13. Pimentel D, Acquay H, Biltonen M, Rice P, Silva M, Nelson J, Lipner V, Giordano S, Horowitz A, D'Amore M (1992): Environmental and economic costs of pesticide use. Bioscience 42:750-760.
14. Ravindranath V (1995): Xenobiotic metabolism in brain. Drug Metab Rev 27:419-448.
15. Scott JG, Georghiou GP (1986): Mechanisms responsible for high levels of permethrin resistance in the house fly. Pestic Sci 17:195-206.
16. Scott JG, Lee SST (1993a): Purification and characterization of a cytochrome P 450 from insecticide susceptible and resistant strains of house fly, Musca domestica L. Arch Insect Biochem Physiol 24:1-19.
17. Scott JG, Lee SST (1993b): Tissue distribution of microsomal cytochrome P-450 monooxygenases and their inducibility by phenobarbital in the insecticide resistant LPR strain of house fly, Musca domestica L. Insect Biochem Mol Biol 23:729-738.
18. Scott JG, Wheelock GD (1992): Characterization of a cytochrome P 450 responsible for a pyrethroid resistance in the housefly. In Mullen CA, Scott JG (eds): Molecular Mechanisms of Insecticide Resistance; New York: American Chemical Society, Symposium Series 505, pp 16-30.
19. lpr in house flies. Arch Insect Biochem Physiol 31:313-323.
20. Wheelock GD, Scott JG (1989): Simultaneous purification of a cytochrome P450 and cytochrome 6.5 from the house fly, Musca domestica L. Insect Biochem 19:481-488.
21. Wheelock GD, Scott JG (1990): Immunological detection of cytochrome P450 from insecticide resistant and susceptible house flies (Musca domestica). Pestic Biochem Physiol 38:130-139.
22. lpr antiserum inhibits specific monooxygenase activities in LPR house fly microsomes. J Exp Zool 264:153-158.
23. lpr in deltamethrin metabolism by pyrethroid-resistant and susceptible strains of house fly. Pestic Biochem Physiol 43:67-77.
24. lpr is developmentally regulated and limited to house fly. J Biochem Toxicol 6:239-246.
25. Wilkinson, CF (1983): The role of mixed function oxidases in insecticide resistance. In Georghiou GP, Saito T. (eds): Pest Resistance to Pesticides. New York: Plenum, pp 175-205.
26. Zhang M, Scott JG (1994): Simple synthesis of pyrethroid metabolites. J Agric Food Chem 42:1779-1782.
27. 5 is essential for cytochrome P 450 CYP6D1 mediated cypermethrin resistance in LPR house flies. Pestic Biochem Physiol 55:150-156.