Differential effects of GABA(A) receptor antagonists in the control of respiratory neuronal discharge patterns

Journal of Neurophysiology

Volumn 80, Issue 5, 1998, Pages 2368-2377

  Dogas, Z ^a   Krolo, M ^a   Stuth, E A ^a   Tonkovic Capin, M ^a   Hopp, F A ^a   McCrimmon, D R ^b   Zuperku, E J ^a,c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; BICUCULLINE; GLYCINE RECEPTOR; PICROTOXIN; STRYCHNINE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL TYPE; COMPETITIVE INHIBITION; DOG; DOSE RESPONSE; DRUG SPECIFICITY; FEMALE; GABAERGIC SYSTEM; HISTOGRAM; MALE; NERVE CELL; NERVE FUNCTION; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RESPIRATION CENTER; RESPIRATION CONTROL; RESPIRATORY NERVE CELL; SINGLE UNIT ACTIVITY; ANIMAL; BREATHING MECHANICS; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; MEDULLA OBLONGATA; MOTONEURON; PERIODICITY; PHYSIOLOGY; SPINAL CORD; STEREOTAXIC SURGERY;

ANIMALS; BICUCULLINE; DOGS; DRUG ANTAGONISM; ELECTROPHYSIOLOGY; FEMALE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MALE; MEDULLA OBLONGATA; MOTOR NEURONS; PERIODICITY; PICROTOXIN; RECEPTORS, GABA-A; RESPIRATORY MECHANICS; SPINAL CORD; STEREOTAXIC TECHNIQUES;

EID: 0031597393     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.80.5.2368     Document Type: Article

References (32)

1. JIC, J., ZUPERKU, E. J., TONKOVIC-CAPIN, M., AND HOPP, F. A. Expiratory bulbospinal neurons of dogs. I. Control of discharge patterns by pulmonary stretch receptors. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R1075-R1086, 1992.
2. BALLANTYNE, D. AND RICHTER, D. W. Post-synaptic inhibition of bulbar inspiratory neurones in the cat. J. Physiol. (Lond.) 384: 67-87, 1984.
3. A receptor subtypes: from pharmacology to molecular biology. FASEB J. 5: 2916-2923, 1991.
4. CHAMPAGNAT, J., DENAVIT-SAUBIÉ, M., MOYANOVA, S., AND RONDOUIN, G. Involvement of amino acids in periodic inhibitions of bulbar respiratory neurons. Brain Res. 237: 351-365, 1982.
5. COHEN, M. I., FELDMAN, J. L., AND SOMMER, D. Caudal medullary expiratory neurone and internal intercostal nerve discharges in the cat: effects of lung inflation. J. Physiol. (Lond.) 368: 147-178, 1985.
6. EZURE, K., MANABE, M., AND OTAKE, K. Excitation and inhibition of medullary inspiratory neurons by two types of burst inspiratory neurons in the cat. Neurosci. Lett. 104: 303-308, 1989.
7. FELDMAN, J. L. AND GRILLNER, S. Control of vertebrate respiration and locomotion: a brief account. Physiologist 26: 310-316: 1983.
8. FRENCH-CONSTANT, R. H., ROCHELEAU, T. A., STEICHEN, J. C., AND CHALMERS, A. E. A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature 363: 449-451, 1993.
9. GURLEY, D., AMIN, J., Ross, P. C., WEISS, D. S., AND WHITE, G. Point mutations in the M2 region of the a, b, or g subunit of the GABAchannel that abolish block by picrotoxin. Receptors Channels 3: 13-20, 1995.
10. HAJI, A., REMMERS, J. E., CONNELLY, C., AND TAKEDA, R. Effects of glycine and GABA on bulbar respiratory neurons of cat. J. Neurophysiol. 63: 955-965, 1990.
11. HAJI, A., TAKEDA, R., AND REMMERS, J. E. Evidence that glycine and GABA mediate postsynaptic inhibition of bulbar respiratory neurons in the cat. J. Appl. Physiol. 73: 2333-2342, 1992.
12. HAYASHI, F., COLES, S. K., AND MCCRIMMON, D. R. Respiratory neurons mediating the Breuer-Hering reflex prolongation of expiration in rat. J. Neurosci. 16: 6526-6536, 1996.
13. HEYER, E. J., NOWAK, L. M., AND MACDONALD, R. L. Bicuculline: a convulsant with synaptic and nonsynaptic actions. Neurology 31: 1381-1390, 1981.
14. KRISHEK, B. J., Moss, S. J., AND SMART, T. G. Functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAreceptors. Neuropharmacology 35: 1289-1298, 1996.
15. KROLO, M., STUTH, E. A., TONKOVIC-CAPIN, M., HOPP, F. A., MCCRTMMON, D. R., AND ZUPERKU, E. J. Relative contributions of tonic and phasic citatory drives to the discharge of inspiratory bulbospinal neurons. Soc. Neurosci. Abstr. 23: 727, 1997.
16. LIU, Q. Y., DUNLAP, V., AND BARKER, J. L. Gamma-aminobutyric acid type A receptor antagonists picrotoxin and bicuculline alter acetylcholine channel kinetics in cultured embryonic rat skeletal muscle. Mol. Pharmacol. 46: 1197-1203, 1994.
17. A receptor subunit mRNAs in the rat locus coeruleus. Mol. Brain Res. 24: 219-226, 1994.
18. A receptor channels. Annu. Rev. Neurosci 17: 569-602, 1994.
19. MATTHEWS, G., AYOUB, G. S., AND HEIDELBERGER, R. Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology. J. Neurosci. 14: 1079-1090, 1994.
20. MCCRIMMON, D. R., ZUPERKU, E. J., HAYASHI, F., DOGAS, Z., HINRICHSEN, C.F.L., STUTH, E. A., TONKOVIC-CAPIN, M., KROLO, M., AND HOPP, F. A. Modulation of the synaptic drive to respiratory premotor and motor neurons. Resp. Physiol. 110: 161-176, 1997.
21. OLSEN, R. W. GABA and inhibitory synaptic transmission in the brain. Neuroscience 3: 175-181, 1991.
22. RAMIREZ, J. M. AND RICHTER, D. W. The neuronal mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 6: 817-825, 1996.
23. RICHTER, D. W. Generation and maintenance of the respiratory rhythm. J. Exp. Biol. 100: 93-108, 1982.
24. RICHTER, D. W., CAMBRER, H., MEESMANN, M., AND ROHRIG, N. Studies on the synaptic interconnection between bulbar respiratory neurons of cats. Pflügers Arch. 380: 245-257, 1979.
25. A receptors shape the discharge patterns of bulbar respiratory neurons. Brain Res. 710: 150-160, 1996.
26. SHIEKHATTAR, R. AND ASTON-JONES, G. Local application of bicuculline potentiates NMDA-receptor-mediated sensory responses of brain noradrenergic neurons. Synapse 10: 54-61, 1992.
27. STUTH, E.A.E., TONKOVIC-CAPIN, M., KAMPINE, J. P., BAJIC, J., AND ZUPERKU, E. J. Dose-dependent effects of halothane on the carbon dioxide responses of expiratory and inspiratory bulbospinal neurons and the phrenic nerve activities in dogs. Anesthesiology 81: 1470-1483, 1994.
28. TOLEIKIS, J. R., WANG, L., AND BOYARSKY, L. L. Effects of excitatory and inhibitory amino acids on phasic respiratory neurons. J. Neurosci. Res. 4: 225-235, 1979.
29. TONKOVIC-CAPIN, M., BAJIC, J., HOPP, F. A., MCCRIMMON, D. R., STUTH, E. A., DOGAS, Z., AND ZUPERKU, E. J. Role of GABA and glycine receptors in the mediation of lung inflation responses of medullary expiratory bulbospinal neurons (Abstract). Physiologist 39: 175, 1996.
30. WALLENSTEIN, S., ZUCKER, C. L., AND FLEISS, J. L. Some statistical methods useful in circulation research. Circ. Res. 47: 3-9, 1980.
31. WANG, L., BOYARSKY, L. L., AND FRAZIER, D. T. The effect of transmitter antagonists on phasic respiratory neurons. J. Neurosci. Res. 8: 657-664, 1982.
32. ZHANG, H.-G., LEE, H.-J., ROCHELEAU, T. A., FFRENCH-CONSTANT, R. H., AND JACKSON, M. B. Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila γ-aminobutyric acid receptors. Mol. Pharmacol. 48: 835-840, 1995.